Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 27(2), С. 683 - 696
Опубликована: Ноя. 11, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity increases risk of cardiovascular disease. This cohort study examines the prognostic value MASLD, across body weight categories, in a secondary preventative acute myocardial infarction (AMI) cohort.
Язык: Английский
Cell Metabolism, Год журнала: 2023, Номер 35(3), С. 414 - 428.e3
Опубликована: Март 1, 2023
Язык: Английский
Процитировано
424
Metabolism, Год журнала: 2023, Номер 141, С. 155402 - 155402
Опубликована: Янв. 28, 2023
Язык: Английский
Процитировано
100
Circulation Cardiovascular Quality and Outcomes, Год журнала: 2023, Номер 16(4)
Опубликована: Март 3, 2023
The double burden of malnutrition, described as the coexistence malnutrition and obesity, is a growing global health issue. This study examines combined effects obesity on patients with acute myocardial infarction (AMI).Patients presenting AMI to percutaneous coronary intervention-capable hospital in Singapore between January 2014 March 2021 were retrospectively studied. Patients stratified into following: (1) nourished nonobese, (2) malnourished (3) obese, (4) obese. Obesity defined according World Health Organization definition (body mass index ≥27.5 kg/m2) Controlling Nutritional Status score, respectively. primary outcome was all-cause mortality. association nutritional status mortality examined using Cox regression, adjusted for age, sex, type, previous AMI, ejection fraction, chronic kidney disease. Kaplan-Meier curves constructed.The included 1829 patients, which 75.7% male mean age 66 years. Over 75% malnourished. Majority nonobese (57.7%), followed by obese (18.8%), (16.9%), (6.6%). Malnourished had highest (38.6%), (35.8%), (21.4%), (9.9%, P<0.001). demonstrated least favorable survival group, With group reference, higher (hazard ratio, 1.46 [95% CI, 1.10-1.96], P=0.010), but only nonsignificant increase observed 1.31 0.94-1.83], P=0.112).Among prevalent even Compared have more unfavorable prognosis especially those severe regardless status, long-term most among patients.
Язык: Английский
Процитировано
24
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 7, 2025
Emerging evidence has demonstrated the unfavourable cardiovascular risk of individuals with lean type 2 diabetes mellitus (T2DM). Our study aims to investigate prognostic value T2DM in patients acute myocardial infarction (AMI), stratified by sex. The cohort examines clinical characteristics and long-term outcomes AMI, four phenotypes based on body category—lean T2DM, non-lean non-T2DM non-T2DM. primary outcome was all-cause mortality. Cox regression model constructed associations mortality, adjusted for age, ethnicity, previous AMI type, chronic kidney disease, angiotensin converting enzyme inhibitor or receptor blockers, beta-blockers, smoking status. A 9545 examined, a mean follow-up duration 3.4 ± 2.4 years. Majority had phenotype (40.4%), followed (29.8%), (15.9%), (13.9%). In group, one-quarter (N = 1324), while vast majority (74.5%) non-lean. Individuals tended be female older. Patients highest rates heart failure (23.3%, p < 0.001), cardiogenic shock (9.1%, 0.036), mortality (32.6%, 0.001). that an independent predictor (adjusted hazard ratio [aHR] 1.171, 95% CI 1.040–1.319, 0.009) after adjustment. presence higher following present males (aHR 1.201, 1.037–1.391, 0.015), but not females 1.066, 0.869–1.308, 0.538). T2DM. although this association stronger than females.
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119560 - 119560
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Obesity, Год журнала: 2023, Номер 31(3), С. 832 - 840
Опубликована: Фев. 7, 2023
Abstract Objective With rising prevalence of hypertension and obesity, the effect in obesity remains an important global issue. The prognosis US general population with based on control was examined. Methods This study examined participants from National Health Nutrition Examination Survey between 1999 2018. Individuals were stratified into no hypertension, controlled uncontrolled hypertension. outcome all‐cause mortality. Cox regression mortality adjusted for age, sex, ethnicity, diabetes, previous myocardial infarction. Results Of 16,386 individuals 53.1% had 24.7% 22.2% All‐cause significantly higher (17.1%), followed by (14.8%) (4.0%). Uncontrolled highest risk (hazard ratio [HR] 1.34, 95% CI: 1.13‐1.59, p = 0.001), (HR 1.21, 1.10‐1.34, < compared after adjustment. excess trend more pronounced females, those older than age 65 years. Conclusions incremental normotensive counterparts, irrespective diabetes status, urges health care providers to optimize advocate weight loss achieve better outcomes obesity.
Язык: Английский
Процитировано
16
International Journal of Cardiology, Год журнала: 2023, Номер 383, С. 140 - 150
Опубликована: Апрель 26, 2023
Язык: Английский
Процитировано
15
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(8), С. 3328 - 3338
Опубликована: Май 23, 2024
Abstract Aim Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) are at increased risk of incident cardiovascular disease. However, the clinical characteristics and prognostic importance MASLD in patients presenting acute myocardial infarction (AMI) have yet to be examined. Methods This study compared outcomes without AMI a tertiary centre Singapore. was defined as hepatic steatosis, least one five criteria. Hepatic steatosis determined using Steatosis Index. Propensity score matching performed adjust for age sex. The Kaplan‐Meier curve constructed long‐term all‐cause mortality. Cox regression analysis used investigate independent predictors Results In this 4446 AMI, 2223 were matched propensity scores. mean follow‐up duration 3.4 ± 2.4 years. group had higher rates obesity, diabetes chronic kidney than their counterparts. early excess mortality (6.8% vs. 3.6%, p < .001) 30 days, unfavourable sustained (18.3% 14.5%, = those MASLD. After adjustment, remained independently associated (hazard ratio 1.330, 95% confidence interval 1.106‐1.598, .002). Conclusion embodies burden dysfunction is an predictor population. Its identification may beneficial stratification provide therapeutic targets secondary preventive strategies AMI.
Язык: Английский
Процитировано
5
Diabetes Obesity and Metabolism, Год журнала: 2022, Номер 25(4), С. 1032 - 1044
Опубликована: Дек. 22, 2022
To examine the prevalence and prognosis of hepatic steatosis fibrosis in post-acute myocardial infarction (AMI) patients.Patients presenting with AMI to a tertiary hospital were examined from 2014 2021. Hepatic advanced determined using Steatosis Index fibrosis-4 index, respectively. The primary outcome was all-cause mortality. Cox regression models identified determinants mortality after adjustments Kaplan-Meier curves constructed for mortality, stratified by fibrosis.Of 5765 patients included, 24.8% had steatosis, whom 41.7% diagnosed fibrosis. median follow-up duration 2.7 years. Patients tended be younger, female, elevated body mass index an increased metabolic burden diabetes, hypertension hyperlipidaemia. (24.6% vs. 20.9% P < .001) (45.6% 32.9% higher rates compared their respective counterparts. (adjusted hazard ratio 1.364, 95% CI 1.145-1.625, = associated adjustment confounders. Survival showed excess those without (P .002).Hepatic have substantial among AMI. Both are incrementally risk when ensues. could help stratification beyond conventional factors.
Язык: Английский
Процитировано
19
The American Journal of Cardiology, Год журнала: 2023, Номер 196, С. 1 - 10
Опубликована: Апрель 5, 2023
Язык: Английский
Процитировано
11