Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 27(2), P. 683 - 696
Published: Nov. 11, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity increases risk of cardiovascular disease. This cohort study examines the prognostic value MASLD, across body weight categories, in a secondary preventative acute myocardial infarction (AMI) cohort.
Language: Английский
Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(3), P. 414 - 428.e3
Published: March 1, 2023
Language: Английский
Citations
396
Metabolism, Journal Year: 2023, Volume and Issue: 141, P. 155402 - 155402
Published: Jan. 28, 2023
Language: Английский
Citations
98
Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 7, 2025
Emerging evidence has demonstrated the unfavourable cardiovascular risk of individuals with lean type 2 diabetes mellitus (T2DM). Our study aims to investigate prognostic value T2DM in patients acute myocardial infarction (AMI), stratified by sex. The cohort examines clinical characteristics and long-term outcomes AMI, four phenotypes based on body category—lean T2DM, non-lean non-T2DM non-T2DM. primary outcome was all-cause mortality. Cox regression model constructed associations mortality, adjusted for age, ethnicity, previous AMI type, chronic kidney disease, angiotensin converting enzyme inhibitor or receptor blockers, beta-blockers, smoking status. A 9545 examined, a mean follow-up duration 3.4 ± 2.4 years. Majority had phenotype (40.4%), followed (29.8%), (15.9%), (13.9%). In group, one-quarter (N = 1324), while vast majority (74.5%) non-lean. Individuals tended be female older. Patients highest rates heart failure (23.3%, p < 0.001), cardiogenic shock (9.1%, 0.036), mortality (32.6%, 0.001). that an independent predictor (adjusted hazard ratio [aHR] 1.171, 95% CI 1.040–1.319, 0.009) after adjustment. presence higher following present males (aHR 1.201, 1.037–1.391, 0.015), but not females 1.066, 0.869–1.308, 0.538). T2DM. although this association stronger than females.
Language: Английский
Citations
1
Circulation Cardiovascular Quality and Outcomes, Journal Year: 2023, Volume and Issue: 16(4)
Published: March 3, 2023
The double burden of malnutrition, described as the coexistence malnutrition and obesity, is a growing global health issue. This study examines combined effects obesity on patients with acute myocardial infarction (AMI).Patients presenting AMI to percutaneous coronary intervention-capable hospital in Singapore between January 2014 March 2021 were retrospectively studied. Patients stratified into following: (1) nourished nonobese, (2) malnourished (3) obese, (4) obese. Obesity defined according World Health Organization definition (body mass index ≥27.5 kg/m2) Controlling Nutritional Status score, respectively. primary outcome was all-cause mortality. association nutritional status mortality examined using Cox regression, adjusted for age, sex, type, previous AMI, ejection fraction, chronic kidney disease. Kaplan-Meier curves constructed.The included 1829 patients, which 75.7% male mean age 66 years. Over 75% malnourished. Majority nonobese (57.7%), followed by obese (18.8%), (16.9%), (6.6%). Malnourished had highest (38.6%), (35.8%), (21.4%), (9.9%, P<0.001). demonstrated least favorable survival group, With group reference, higher (hazard ratio, 1.46 [95% CI, 1.10-1.96], P=0.010), but only nonsignificant increase observed 1.31 0.94-1.83], P=0.112).Among prevalent even Compared have more unfavorable prognosis especially those severe regardless status, long-term most among patients.
Language: Английский
Citations
22
Obesity, Journal Year: 2023, Volume and Issue: 31(3), P. 832 - 840
Published: Feb. 7, 2023
Abstract Objective With rising prevalence of hypertension and obesity, the effect in obesity remains an important global issue. The prognosis US general population with based on control was examined. Methods This study examined participants from National Health Nutrition Examination Survey between 1999 2018. Individuals were stratified into no hypertension, controlled uncontrolled hypertension. outcome all‐cause mortality. Cox regression mortality adjusted for age, sex, ethnicity, diabetes, previous myocardial infarction. Results Of 16,386 individuals 53.1% had 24.7% 22.2% All‐cause significantly higher (17.1%), followed by (14.8%) (4.0%). Uncontrolled highest risk (hazard ratio [HR] 1.34, 95% CI: 1.13‐1.59, p = 0.001), (HR 1.21, 1.10‐1.34, < compared after adjustment. excess trend more pronounced females, those older than age 65 years. Conclusions incremental normotensive counterparts, irrespective diabetes status, urges health care providers to optimize advocate weight loss achieve better outcomes obesity.
Language: Английский
Citations
15
International Journal of Cardiology, Journal Year: 2023, Volume and Issue: 383, P. 140 - 150
Published: April 26, 2023
Language: Английский
Citations
13
Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(8), P. 3328 - 3338
Published: May 23, 2024
Abstract Aim Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) are at increased risk of incident cardiovascular disease. However, the clinical characteristics and prognostic importance MASLD in patients presenting acute myocardial infarction (AMI) have yet to be examined. Methods This study compared outcomes without AMI a tertiary centre Singapore. was defined as hepatic steatosis, least one five criteria. Hepatic steatosis determined using Steatosis Index. Propensity score matching performed adjust for age sex. The Kaplan‐Meier curve constructed long‐term all‐cause mortality. Cox regression analysis used investigate independent predictors Results In this 4446 AMI, 2223 were matched propensity scores. mean follow‐up duration 3.4 ± 2.4 years. group had higher rates obesity, diabetes chronic kidney than their counterparts. early excess mortality (6.8% vs. 3.6%, p < .001) 30 days, unfavourable sustained (18.3% 14.5%, = those MASLD. After adjustment, remained independently associated (hazard ratio 1.330, 95% confidence interval 1.106‐1.598, .002). Conclusion embodies burden dysfunction is an predictor population. Its identification may beneficial stratification provide therapeutic targets secondary preventive strategies AMI.
Language: Английский
Citations
5
The American Journal of Cardiology, Journal Year: 2023, Volume and Issue: 196, P. 1 - 10
Published: April 5, 2023
Language: Английский
Citations
11
Diabetes Obesity and Metabolism, Journal Year: 2022, Volume and Issue: 25(4), P. 1032 - 1044
Published: Dec. 22, 2022
To examine the prevalence and prognosis of hepatic steatosis fibrosis in post-acute myocardial infarction (AMI) patients.Patients presenting with AMI to a tertiary hospital were examined from 2014 2021. Hepatic advanced determined using Steatosis Index fibrosis-4 index, respectively. The primary outcome was all-cause mortality. Cox regression models identified determinants mortality after adjustments Kaplan-Meier curves constructed for mortality, stratified by fibrosis.Of 5765 patients included, 24.8% had steatosis, whom 41.7% diagnosed fibrosis. median follow-up duration 2.7 years. Patients tended be younger, female, elevated body mass index an increased metabolic burden diabetes, hypertension hyperlipidaemia. (24.6% vs. 20.9% P < .001) (45.6% 32.9% higher rates compared their respective counterparts. (adjusted hazard ratio 1.364, 95% CI 1.145-1.625, = associated adjustment confounders. Survival showed excess those without (P .002).Hepatic have substantial among AMI. Both are incrementally risk when ensues. could help stratification beyond conventional factors.
Language: Английский
Citations
18
Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10
Published: May 22, 2023
EDITORIAL article Front. Med., 22 May 2023Sec. Gastroenterology Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1209625
Language: Английский
Citations
10