Night owls of Rio de la Plata region: Real-life scenarios to understand the biological clock

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2020, Номер 21(4), С. 465 - 478

Опубликована: Июль 21, 2020

Язык: Английский

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Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2021, Номер 41(9), С. 2137 - 2149

Опубликована: Янв. 18, 2021

Age-related neurodegenerative diseases are a growing burden to society, and many sporadic, meaning that the environment, diet lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding diseases. The system involved in clearance metabolic by-products such amyloid-β from brain, its function believed lower risk developing some most common Here, we present magnetic resonance imaging (MRI) data heart cycle's control CSF flow humans which corroborates findings animal studies. We also review importance sleep, diet, vascular health for find these factors known players longevity.

Язык: Английский

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Optogenetics for visual restoration: From proof of principle to translational challenges

Progress in Retinal and Eye Research, Год журнала: 2022, Номер 91, С. 101089 - 101089

Опубликована: Июнь 10, 2022

Degenerative retinal disorders are a diverse family of diseases commonly leading to irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent years, innovative gene replacement therapies aiming halt progression certain inherited have made their way into clinics. By rendering surviving neurons light sensitive optogenetic therapy now offers feasible treatment option that can restore lost vision, even in late disease stages and widely independent underlying cause degeneration. Since proof-of-concept almost fifteen years ago, this field has rapidly evolved detailed first report on treated patient recently been published. In article, we provide review approaches for vision restoration. We discuss currently available tools relative advantages disadvantages. Possible cellular targets will be discussed address question how remodelling may affect choice target what extent it limit outcomes Finally, analyse evidence against tool mediated toxicity challenges associated with clinical translation promising therapeutic concept.

Язык: Английский

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Social and circadian rhythm dysregulation and suicide: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105560 - 105560

Опубликована: Янв. 23, 2024

Язык: Английский

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