Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105560 - 105560
Published: Jan. 23, 2024
Language: Английский
Reviews in Endocrine and Metabolic Disorders, Journal Year: 2020, Volume and Issue: 21(4), P. 465 - 478
Published: July 21, 2020
Language: Английский
Citations
58
Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2021, Volume and Issue: 41(9), P. 2137 - 2149
Published: Jan. 18, 2021
Age-related neurodegenerative diseases are a growing burden to society, and many sporadic, meaning that the environment, diet lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding diseases. The system involved in clearance metabolic by-products such amyloid-β from brain, its function believed lower risk developing some most common Here, we present magnetic resonance imaging (MRI) data heart cycle's control CSF flow humans which corroborates findings animal studies. We also review importance sleep, diet, vascular health for find these factors known players longevity.
Language: Английский
Citations
48
Progress in Retinal and Eye Research, Journal Year: 2022, Volume and Issue: 91, P. 101089 - 101089
Published: June 10, 2022
Degenerative retinal disorders are a diverse family of diseases commonly leading to irreversible photoreceptor death, while leaving the inner retina relatively intact. Over recent years, innovative gene replacement therapies aiming halt progression certain inherited have made their way into clinics. By rendering surviving neurons light sensitive optogenetic therapy now offers feasible treatment option that can restore lost vision, even in late disease stages and widely independent underlying cause degeneration. Since proof-of-concept almost fifteen years ago, this field has rapidly evolved detailed first report on treated patient recently been published. In article, we provide review approaches for vision restoration. We discuss currently available tools relative advantages disadvantages. Possible cellular targets will be discussed address question how remodelling may affect choice target what extent it limit outcomes Finally, analyse evidence against tool mediated toxicity challenges associated with clinical translation promising therapeutic concept.
Language: Английский
Citations
37
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)
Published: Oct. 15, 2024
Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts risk has not been established. We therefore investigated whether day and night light, patterns disrupt predicted UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore sensors for 1 wk. Day exposures were defined by factor analysis 24-h profiles. A computational model human pacemaker was applied amplitude phase from data. Cause-specific recorded in 3,750 across a mean (±SD) follow-up period 8.0 1.0 y. Individuals with brighter had incrementally lower all-cause (adjusted-HR ranges: 0.84 0.90 [50 70th percentiles], 0.74 [70 90th], 0.66 0.83 [90 100th]), those higher (aHR 1.15 1.18 1.21 1.34 compared individuals darker environments (0 50th percentiles). range: 0.96 per SD), earlier 1.16 1.30), later 1.13 1.20) risks. cardiometabolic mortality, larger hazard ratios than other causes. Findings robust adjustment age, sex, ethnicity, photoperiod, sociodemographic lifestyle factors. Minimizing maximizing keeping regular light–dark enhance rhythms may promote longevity.
Language: Английский
Citations
8
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105560 - 105560
Published: Jan. 23, 2024
Language: Английский
Citations
7