bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 21, 2024
Abstract
Background
Combined
transcranial
magnetic
stimulation
and
electroencephalography
(TMS-EEG)
is
widely
used
to
probe
cortical
excitability
at
the
network
level,
but
technical
challenges
have
prevented
its
application
investigate
local
of
stimulated
area.
A
recent
study
revealed
immediate
TMS-evoked
potentials
(i-TEPs)
after
primary
motor
cortex
(M1)
stimulation,
suggesting
that
it
may
represent
a
response.
Here,
we
aimed
testing
if
this
activity
physiological
in
nature
what
represents.
Methods
We
analyzed
TMS-EEG
dataset
from
28
healthy
participants
recorded
9.6
kHz
including
two
M1
conditions
with
opposite
biphasic
current
directions.
localized
brain
sources
i-TEPs,
calculated
TMS-related
power
(i-TRP)
distinguish
between
oscillatory
components
contribute
investigated
relationship
i-TRP
motor-evoked
(MEPs).
In
an
additional
recording,
control
site
evoking
muscular
response
understand
contribution
muscle
artifact.
Results
confirmed
i-TEPs
similar
characteristics
as
previously
described.
The
strong
ranges
600-800
Hz
100-200
Hz;
former
was
positively
associated
MEPs
amplitude
for
both
direction
conditions.
Moreover,
were
precentral
gyrus
hemisphere
generated
by
differed
i-TRP.
Discussion
These
findings
provide
first
evidence
on
following
represents
direct
measure
cortex.
NeuroImage,
Год журнала:
2025,
Номер
308, С. 121082 - 121082
Опубликована: Фев. 9, 2025
Motor
resonance
-
the
facilitation
of
corticospinal
excitability
during
action
observation
is
considered
a
proxy
Action
Observation
Network
(AON)
recruitment
in
humans,
with
profound
implications
for
social
cognition
and
understanding.
Despite
extensive
research,
neural
underpinnings
supporting
motor
emergence
rewriting
remain
unexplored.
In
this
study,
we
investigated
role
sensorimotor
associative
learning
mechanisms
underlying
phenomenon.
To
aim,
applied
cross-systems
paired
stimulation
(PAS)
to
induce
novel
visuomotor
associations
human
brain.
This
protocol,
which
repeatedly
pairs
transcranial
magnetic
(TMS)
pulses
over
primary
cortex
(M1)
visual
stimuli
actions,
drives
an
atypical,
PAS-conditioned
response.
Using
TMS
electroencephalography
(EEG)
co-registration
observation,
tracked
M1
functional
connectivity
profile
process
map
inter-areal
profiles
associated
typical
PAS-induced
phenomena.
Besides
confirming,
at
level,
newly
acquired
responses
cost
ones
after
PAS
administration,
our
results
reveal
dissociable
aspects
interregional
communication.
On
one
side,
effects
through
lifespan
are
prominent
alpha-band
reduced
beta-band
connectivity,
might
facilitate
output
while
integrating
information.
Conversely,
atypical
linked
cortical
modulations,
only
partially
overlapping
communication
patterns
related
mirroring
responses.
evidence
suggests
that
beta-phase
synchronization
may
be
critical
mechanism
formation
by
coordinating
activity
regions
also
involves
top-down
control
frontal
areas.
These
findings
provide
new
insights
into
dynamics
(typical
acquired)
resonance,
highlighting
large-scale
within
AON.
Abstract
Transcranial
magnetic
stimulation
(TMS)-evoked
potentials
(TEPs)
represent
an
innovative
measure
for
examining
brain
connectivity
and
developing
biomarkers
of
psychiatric
conditions.
Minimizing
TEP
variability
across
studies
participants,
which
may
stem
from
methodological
choices,
is
therefore
vital.
By
combining
classic
peak
analysis
microstate
investigation,
we
tested
how
TMS
pulse
waveform
current
direction
affect
cortico-cortical
circuit
engagement
when
targeting
the
primary
motor
cortex
(M1).
We
aim
to
disentangle
whether
changing
these
parameters
affects
degree
activation
same
neural
circuitry
or
lead
changes
in
pathways
through
induced
spreads.
Thirty-two
healthy
participants
underwent
a
TMS-EEG
experiment
(monophasic,
biphasic)
(posterior-anterior,
anterior-posterior,
latero-medial)
were
manipulated.
assessed
latency
amplitude
M1-TEP
components
employed
analyses
test
differences
topographies.
Results
revealed
that
strongly
influenced
components’
but
had
weaker
role
over
their
latencies.
Microstate
showed
monophasic
stimulations
changed
pattern
evoked
microstates
at
early
latencies,
as
well
duration
global
field
power.
This
study
shows
pulses
modulate
cortical
sources
contributing
signals,
activating
populations
paths
more
selectively.
Biphasic
reduces
associated
with
be
better
suited
blind
anatomical
information.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 10, 2024
ABSTRACT
Motor
resonance
–
the
activation
of
observer’s
motor
system
when
viewing
others’
actions
grounds
intertwined
nature
action
perception
and
execution,
with
profound
implications
for
social
cognition
understanding.
Despite
extensive
research,
neural
underpinnings
supporting
emergence
rewriting
remain
unexplored.
In
this
study,
we
investigated
role
sensorimotor
associative
learning
in
mechanisms.
To
aim,
applied
cross-systems
paired
stimulation
(PAS)
to
induce
novel
visuomotor
associations
human
brain.
This
protocol,
which
repeatedly
pairs
transcranial
magnetic
(TMS)
pulses
over
primary
cortex
(M1)
visual
stimuli
actions,
drives
an
atypical,
PAS-conditioned
response.
Using
TMS
electroencephalography
(EEG)
co-registration
during
observation,
tracked
M1
functional
connectivity
profile
process
map
inter-areal
profiles
associated
typical
PAS-induced
phenomena.
Besides
confirming,
at
corticospinal
level,
newly
acquired
responses
cost
ones
after
PAS
administration,
our
results
reveal
dissociable
aspects
interregional
communication.
On
one
side,
effects
through
lifespan
are
prominent
alpha-band
reduced
beta-band
connectivity,
might
facilitate
output
while
integrating
information.
Conversely,
atypical
is
linked
cortical
modulations,
only
partially
overlapping
communication
patterns
related
mirroring
responses.
evidence
suggests
that
beta-phase
synchronization
may
be
critical
mechanism
formation
by
coordinating
activity
regions
also
involves
top-down
control
frontal
areas.
These
findings
provide
new
insights
into
dynamics
underlying
(typical
acquired)
resonance,
highlighting
large-scale
within
observation
network.
Clinical Neurophysiology,
Год журнала:
2024,
Номер
168, С. 139 - 152
Опубликована: Ноя. 6, 2024
Patients
with
borderline
personality
disorder
(pw-BPD)
have
decreased
levels
of
cognitive
empathy,
which
may
be
subtended
by
mirror-like
mechanisms
in
the
somatosensory
cortices,
i.e.,
Tactile
Mirror
System
(TaMS).
Here,
we
aimed
to
shed
light
on
TaMS
and
empathic
deficits
pw-BPD
focusing
connectivity,
using
transcranial
magnetic
stimulation
electroencephalography
(TMS-EEG).
