M1 Large-scale Network Dynamics Support Human Motor Resonance and Its Plastic Reshaping

NeuroImage, Journal Year: 2025, Volume and Issue: 308, P. 121082 - 121082

Published: Feb. 9, 2025

Motor resonance - the facilitation of corticospinal excitability during action observation is considered a proxy Action Observation Network (AON) recruitment in humans, with profound implications for social cognition and understanding. Despite extensive research, neural underpinnings supporting motor emergence rewriting remain unexplored. In this study, we investigated role sensorimotor associative learning mechanisms underlying phenomenon. To aim, applied cross-systems paired stimulation (PAS) to induce novel visuomotor associations human brain. This protocol, which repeatedly pairs transcranial magnetic (TMS) pulses over primary cortex (M1) visual stimuli actions, drives an atypical, PAS-conditioned response. Using TMS electroencephalography (EEG) co-registration observation, tracked M1 functional connectivity profile process map inter-areal profiles associated typical PAS-induced phenomena. Besides confirming, at level, newly acquired responses cost ones after PAS administration, our results reveal dissociable aspects interregional communication. On one side, effects through lifespan are prominent alpha-band reduced beta-band connectivity, might facilitate output while integrating information. Conversely, atypical linked cortical modulations, only partially overlapping communication patterns related mirroring responses. evidence suggests that beta-phase synchronization may be critical mechanism formation by coordinating activity regions also involves top-down control frontal areas. These findings provide new insights into dynamics (typical acquired) resonance, highlighting large-scale within AON.

Language: Английский

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The Recurrent Neural Networks: Algorithm Driven Alchemy of Machine Learning into Precision Therapeutics for Today and Tomorrow

SSRN Electronic Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Association of TMS-EEG interhemispheric imbalance with upper limb motor impairment in chronic stroke patients: An exploratory study

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: 171, P. 95 - 106

Published: Jan. 20, 2025

Language: Английский

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Bridging the gap to clinical use: A systematic review on TMS–EEG test-retest reliability

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: 171, P. 133 - 145

Published: Jan. 24, 2025

Language: Английский

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Stimulation Parameters Recruit Distinct Cortico-Cortical Pathways: Insights from Microstate Analysis on TMS-Evoked Potentials

Brain Topography, Journal Year: 2025, Volume and Issue: 38(3)

Published: March 28, 2025

Abstract Transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) represent an innovative measure for examining brain connectivity and developing biomarkers of psychiatric conditions. Minimizing TEP variability across studies participants, which may stem from methodological choices, is therefore vital. By combining classic peak analysis microstate investigation, we tested how TMS pulse waveform current direction affect cortico-cortical circuit engagement when targeting the primary motor cortex (M1). We aim to disentangle whether changing these parameters affects degree activation same neural circuitry or lead changes in pathways through induced spreads. Thirty-two healthy participants underwent a TMS-EEG experiment (monophasic, biphasic) (posterior-anterior, anterior-posterior, latero-medial) were manipulated. assessed latency amplitude M1-TEP components employed analyses test differences topographies. Results revealed that strongly influenced components’ but had weaker role over their latencies. Microstate showed monophasic stimulations changed pattern evoked microstates at early latencies, as well duration global field power. This study shows pulses modulate cortical sources contributing signals, activating populations paths more selectively. Biphasic reduces associated with be better suited blind anatomical information.

Language: Английский

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M1 Large-scale Network Dynamics Support Human Motor Resonance and Its Plastic Reshaping

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

ABSTRACT Motor resonance – the activation of observer’s motor system when viewing others’ actions grounds intertwined nature action perception and execution, with profound implications for social cognition understanding. Despite extensive research, neural underpinnings supporting emergence rewriting remain unexplored. In this study, we investigated role sensorimotor associative learning in mechanisms. To aim, applied cross-systems paired stimulation (PAS) to induce novel visuomotor associations human brain. This protocol, which repeatedly pairs transcranial magnetic (TMS) pulses over primary cortex (M1) visual stimuli actions, drives an atypical, PAS-conditioned response. Using TMS electroencephalography (EEG) co-registration during observation, tracked M1 functional connectivity profile process map inter-areal profiles associated typical PAS-induced phenomena. Besides confirming, at corticospinal level, newly acquired responses cost ones after PAS administration, our results reveal dissociable aspects interregional communication. On one side, effects through lifespan are prominent alpha-band reduced beta-band connectivity, might facilitate output while integrating information. Conversely, atypical is linked cortical modulations, only partially overlapping communication patterns related mirroring responses. evidence suggests that beta-phase synchronization may be critical mechanism formation by coordinating activity regions also involves top-down control frontal areas. These findings provide new insights into dynamics underlying (typical acquired) resonance, highlighting large-scale within observation network.

Language: Английский

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Investigating visuo-tactile mirror properties in borderline personality disorder: A TMS-EEG study

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: 168, P. 139 - 152

Published: Nov. 6, 2024

Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., Tactile Mirror System (TaMS). Here, we aimed to shed light on TaMS and empathic deficits pw-BPD focusing connectivity, using transcranial magnetic stimulation electroencephalography (TMS-EEG).

Language: Английский

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Transcranial Magnetic Stimulation

Neuromethods, Journal Year: 2024, Volume and Issue: unknown, P. 461 - 508

Published: Dec. 11, 2024

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Can TMS-evoked potentials act as biomarkers of long-term potentiation or long-term depression induced by paired associative stimulation?

Peer Community In Registered Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

A recommendation of: Eleonora Arrigoni, Nadia Bolognini, Alberto Pisoni, Giacomo Guidali Neurophysiological correlates of plasticity induced by paired associative stimulation (PAS) targeting the motor cortex: a TMS-EEG registered report https://osf.io/detjc

Language: Английский

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Monitoring Changes in TMS-Evoked EEG and EMG Activity During 1 Hz rTMS of the Healthy Motor Cortex

eNeuro, Journal Year: 2024, Volume and Issue: 11(4), P. ENEURO.0309 - 23.2024

Published: April 1, 2024

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain technique capable of inducing neuroplasticity as measured by changes in peripheral muscle electromyography (EMG) or electroencephalography (EEG) from pre-to-post stimulation. However, temporal courses neuromodulation during ongoing rTMS are unclear. Monitoring cortical dynamics via TMS-evoked responses using EMG (motor-evoked potentials; MEPs) and EEG (transcranial-evoked TEPs) might provide further essential insights into its mode action – course potential modulations. The objective this study was to first evaluate the validity online rTMS-EEG rTMS-EMG analyses, second scrutinize TEPs MEPs rTMS. As subject high inter-individual effect variability, we aimed for single-subject analyses Ten healthy human participants were stimulated with 1,000 pulses 1 Hz over motor cortex, while recorded continuously. Validity assessed sensor source space. Electrophysiological evaluated model fitting approaches on group- level. appearance consistent past findings single pulse experiments. Heterogeneous progressions, fluctuations saturation effects activity observed depending TEP component. Overall, global increased Single-subject analysis revealed activity. present favor dose-response considerations attempts personalization protocols.

Language: Английский

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