Associations between diet and disease progression and symptomatology in multiple sclerosis: A systematic review of observational studies

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 87, С. 105636 - 105636

Опубликована: Апрель 17, 2024

Язык: Английский

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Diet and omega-3 and vitamin D supplement use predict five-year fatigue and disability trajectories in people with multiple sclerosis

Multiple Sclerosis and Related Disorders, Год журнала: 2024, Номер 86, С. 105615 - 105615

Опубликована: Апрель 8, 2024

Fatigue and disability are indicators of disease progression experienced by many people with multiple sclerosis (pwMS). Understanding trajectories these outcomes, their predictors, may provide insight to potential interventions for MS management.

Язык: Английский

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Evaluating patient care in multiple sclerosis: Impact of combined digital tools and holistic management strategies

Multiple Sclerosis Journal - Experimental Translational and Clinical, Год журнала: 2025, Номер 11(2)

Опубликована: Апрель 1, 2025

Background Innovations are essential to meet the needs of people with MS (PwMS), particularly in addressing delays diagnosis and treatment, supporting patient self-management. Objectives To evaluate real-world use outcomes digital technologies holistic management strategies for at a UK Centre. Methods Digital tools PwMS included Patients Know Best (a personal health record) CONNECTPlus ® (an educational app). Tools healthcare professionals Infoflex clinical database MSProDiscuss assessing disease progression). A Healthy Lifestyle Clinic was introduced promote brain health. The impact these interventions on time-to-diagnosis, time-to-disease-modifying therapy (DMT) initiation, non-elective admissions, hospital costs evaluated retrospectively from 2018 2023, comparing pre-intervention (2018–2019) post-intervention (2020–2023) periods, while accounting separately COVID-19 years (2020–2021). Results Trends indicated higher likelihood progression patients delayed (p < 0.001), reduction time DMT an average 23.5 5.8 months = 0.024), post-MS implementation. Non-elective admissions also decreased compared neighbouring hospitals. Conclusions were associated positive trends care delivery. Further research is needed validate findings.

Язык: Английский

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Baseline engagement with healthy lifestyles and their associations with health outcomes in people with multiple sclerosis enrolled in an online multimodal lifestyle course

European Journal of Neurology, Год журнала: 2024, Номер 31(10)

Опубликована: Авг. 7, 2024

Healthy lifestyle behaviour modification may improve health outcomes in people with multiple sclerosis (pwMS), but empirical evidence is needed to confirm prior study findings. We developed an online multimodal intervention (Multiple Sclerosis Online Course) examine the impact of on pwMS via a randomized control trial (RCT). However, present specifically analyses baseline data assess engagement healthy lifestyles by RCT participants and cross-sectional associations outcomes.

Язык: Английский

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Lifestyle changes and patient-reported outcomes over five years in a sample of people with multiple sclerosis after a single multimodal intensive lifestyle education workshop

Neurological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Abstract Introduction Modifiable lifestyle risk factors for progression of multiple sclerosis (MS) have been increasingly studied. This study employed a single-group design involving one-off intensive live-in educational workshop on modification people with MS. We aimed to examine changes in range clinical and variables quality life, self-efficacy, physical impact MS disability from baseline 3- 5-years post-intervention. Methods 95 participants completed the survey. Data included diet quality, meat dairy consumption, omega 3 vitamin D supplementation, activity, stress reducing activities, smoking status, use disease-modifying therapies (DMTs). Patient-reported outcomes health-related disability. Generalised estimating equation models were used account within-participant correlation over time. Results Sixty (63.2%) provided data at 5-years. Significant improvements non-smoking seen both timepoints. Use DMTs remained unchanged. Mental (8.8- 6.9-point) (10.5- 7.3-point) self-efficacy (2.4- 1.9-point) improved significantly 5-years, respectively. Physical reduced 3-years (-3.7 points) trend towards reduction (-2.9 points; p = 0.079). Conclusions Education can lead short long-term mental wellbeing outcomes. suggest potential value as an adjunctive component standard therapy

Язык: Английский

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A web-based lifestyle-related course for people living with multiple sclerosis: evaluation of course completion, satisfaction, and lifestyle changes of participants enrolled in a randomised controlled trial (Preprint)

Опубликована: Апрель 18, 2024

Web-based health/lifestyle-related courses have the potential to increase disease-related knowledge and facilitate lifestyle changes in people living with multiple sclerosis (plwMS). However, a limited number of studies evaluated engagement online learning by plwMS factors influencing this engagement. The present study assessed effectiveness novel 6-week web-based lifestyle-related course (the Multiple Sclerosis Online Course [MSOC]) for improving health outcomes as part large, international randomised controlled trial (RCT). In study, we participant MSOC preliminary outcomes. To quantitatively assess engagement, motivators, barriers completion, satisfaction levels, forum intentions change among participants larger RCT. Sociodemographic data were collected baseline survey completed prior commencement. Summary statistics used examine following completers: motivators satisfaction, course, participation facilitated forum, adopt non-completers: completion. Chi-square t-tests utilised differences between two arms – intervention (IC) standard-care (SCC). Multivariate linear regression models course-, sociodemographic-, health-related associated participants’ change, adjusting behaviours. Additionally, moderation analyses undertaken explore effects arm allocation. possible arm. Of 857 enrolled RCT who survey, 442 (51.6%) (218 IC, 224 SCC). these, 291 evaluation survey; 88% (254/291) completers 12% (37/291) non-completers. Primary motivating underlying completion included: desire participate MS research, optimise health, flexibility (self-paced learning), perception content relevant useful. included personal time constraints technical issues. majority rated “excellent/very good” (73% IC 61% SCC; p=0.17). Many engaged facilitator-led community (44% 25% p=0.003). Preliminary was evidenced significant proportion expressing their result course. particular, more IC-completers expressed alter diet (71% vs 58%, p=0.036), sun exposure (66% 50%, p=0.014), supplement omega-3 (67% 48%; p=0.004), practice meditation (69% 52%, p=0.009). High new content, an interest seeking additional information across arms. Findings support utility providing MS-related encouraging plwMS.Insights into identified current such may guide development future interventions plwMS. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12621001605886

Язык: Английский

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Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials

Sclerosis, Год журнала: 2024, Номер 2(3), С. 156 - 165

Опубликована: Июль 4, 2024

Emerging evidence links dietary interventions to favorable multiple sclerosis (MS) outcomes; however, for the efficacy of on functional disability remains sparse. Data from two 12-week, randomized, controlled pilot trials were pooled investigate a modified Paleolithic diet (Paleo) disability, as assessed by MS Functional Composite (MSFC), among people diagnosed with MS. Pooled baseline-referenced MSFC scores calculated nine-hole peg test (NHPT), timed 25-foot walk (T25FW), and Paced Auditory Serial Addition Test (PASAT) Z-scores. There was no significant difference in mean change between groups (

Язык: Английский

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Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis

Multiple Sclerosis Journal, Год журнала: 2024, Номер 30(8), С. 1056 - 1065

Опубликована: Июль 1, 2024

Background: Understanding nutrition’s role in multiple sclerosis (MS) can guide recommendations and intervention-based studies. Objective: Evaluate the association between nutrition pediatric-onset MS outcomes. Methods: Prospective longitudinal multicenter study conducted as part of US Network Pediatric centers. Predictors were collected using a food screener estimating intake various dietary groups (e.g. dairy fruits) additional calculated indices Healthy Eating Index (HEI)). Outcomes included time-from-enrollment to clinical relapse, new magnetic resonance imaging (MRI) T2 lesions, Expanded Disability Status Scale (EDSS) increase. Results: 353 children with enrolled (mean ± SD age 15.4 2.9, follow-up 3.9 2.6 years). Multivariable analysis demonstrated that increased by 50% recommended was associated relapse risk 41% (adjusted hazard ratio (HR) 1.41, 95% CI 1.07–1.86), progression 40% (1.40, 1.12–1.74). Increased fruit or vegetable above recommended, every five-point HEI increase decreased 25% (0.75, 0.60–0.95), 45% (0.55, 0.32–0.96), 15% (0.84, 0.74–0.96), respectively. No associations found EDSS. Conclusion: This work supports influence on course, particularly intake. Future prospective is required establish causation.

Язык: Английский

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Sociodemographic, Health, and Lifestyle-Related Characteristics Associated With the Commencement and Completion of a Web-Based Lifestyle Educational Program for People With Multiple Sclerosis: Randomized Controlled Trial

Journal of Medical Internet Research, Год журнала: 2024, Номер 26, С. e58253 - e58253

Опубликована: Авг. 28, 2024

Background Digital health interventions increase access to multiple sclerosis (MS)–related knowledge for people living with MS; however, our understanding of factors associated engagement in web-based learning is limited. Objective This study aims examine associations between participant sociodemographic, health, and lifestyle-related characteristics the commencement completion Multiple Sclerosis Online Course (MSOC) a randomized controlled trial (RCT). Methods An intervention course was developed based on Overcoming MS Program—an evidence-based lifestyle modification program MS, standard care international website information. RCT conducted compare effectiveness versus improving outcomes MS. Participant data were collected from baseline survey. Associations MSOC completion, respectively, assessed using multivariate log-binomial regression. Results Overall, 1893 participants enrolled RCT, 45.27% (n=857) completed survey: 23.5% (n=444) 21.8% (n=413) course. Of these 857 participants, 631 (73.6%) commenced or course, 49.1% (218/444) 54.2% (224/413) respectively. University education, partnered relationship status, higher mental physical quality life 19%, 12%, 20%, 22% rates commencement, Clinically significant fatigue 10% reduction likelihood commencement. Strongest included middle older adulthood, male sex, fatigue, preexisting adherence diet program, 96%, 27%, 24%, 19% observed, whereas self-efficacy up 35% lower completion. practicing meditation (20% completion), employment Conclusions Sociodemographic clinical factors, as well important These may help guide design enhancement digital tailored Trial Registration Australian New Zealand Clinical Trials Registry ACTRN12621001605886; https://tinyurl.com/2vyve9p9 International Registered Report Identifier (IRRID) RR2-10.1186/s12883-023-03298-0

Язык: Английский

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Sociodemographic, Health, and Lifestyle-Related Characteristics Associated With the Commencement and Completion of a Web-Based Lifestyle Educational Program for People With Multiple Sclerosis: Randomized Controlled Trial (Preprint)

Опубликована: Март 11, 2024

Digital health interventions increase access to multiple sclerosis (MS)–related knowledge for people living with MS; however, our understanding of factors associated engagement in web-based learning is limited. This study aims examine associations between participant sociodemographic, health, and lifestyle-related characteristics the commencement completion Multiple Sclerosis Online Course (MSOC) a randomized controlled trial (RCT). An intervention course was developed based on Overcoming MS Program—an evidence-based lifestyle modification program MS, standard care international website information. RCT conducted compare effectiveness versus improving outcomes MS. Participant data were collected from baseline survey. Associations MSOC completion, respectively, assessed using multivariate log-binomial regression. Overall, 1893 participants enrolled RCT, 45.27% (n=857) completed survey: 23.5% (n=444) 21.8% (n=413) course. Of these 857 participants, 631 (73.6%) commenced or course, 49.1% (218/444) 54.2% (224/413) respectively. University education, partnered relationship status, higher mental physical quality life 19%, 12%, 20%, 22% rates commencement, Clinically significant fatigue 10% reduction likelihood commencement. Strongest included middle older adulthood, male sex, fatigue, preexisting adherence diet program, 96%, 27%, 24%, 19% observed, whereas self-efficacy up 35% lower completion. practicing meditation (20% completion), employment Sociodemographic clinical factors, as well important These may help guide design enhancement digital tailored Australian New Zealand Clinical Trials Registry ACTRN12621001605886; https://tinyurl.com/2vyve9p9 RR2-10.1186/s12883-023-03298-0

Язык: Английский

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