Abstract
Objectives
This
study
aimed
to
investigate
the
differences
in
structural
connectivity
and
glymphatic
system
function
between
patients
with
temporal
lobe
epilepsy
(TLE)
hippocampal
sclerosis
(HS)
healthy
controls.
Additionally,
we
analyzed
association
connectivity,
function,
antiseizure
medication
(ASM)
response.
Methods
We
retrospectively
enrolled
TLE
HS
controls
who
underwent
diffusion
tensor
imaging
at
our
hospital.
assessed
by
calculating
network
measures
using
graph
theory
evaluated
image
analysis
along
perivascular
space
(DTI‐ALPS)
index.
Patients
were
categorized
into
two
groups:
ASM
poor
good
responders.
Results
55
53
Of
HS,
39
responders,
16
The
assortativity
coefficient
was
higher
than
that
(0.004
vs.
−0.007,
p
=
0.004),
responders
lower
(−0.001
−0.197,
0.003).
DTI‐ALPS
index
(1.403
1.709,
<
0.001);
however,
did
not
differ
(1.411
1.385,
0.628).
had
a
significant
negative
correlation
age
(
r
−0.267,
0.049).
Significance
confirmed
increased
decreased
compared
demonstrated
an
response
HS.
Plain
Language
Summary
investigates
relationship
brain
changes
sclerosis.
research
reveals
these
show
altered
individuals.
A
key
finding
is
strong
link
specific
measure
(assortativity
coefficient)
response,
providing
valuable
insights
could
influence
treatment
future
directions.
Magnetic Resonance in Medical Sciences,
Год журнала:
2024,
Номер
23(3), С. 268 - 290
Опубликована: Янв. 1, 2024
More
than
5
years
have
passed
since
the
Diffusion
Tensor
Image
Analysis
ALong
Perivascular
Space
(DTI-ALPS)
method
was
proposed
with
intention
of
evaluating
glymphatic
system.
This
is
handy
due
to
its
noninvasiveness,
provision
a
simple
index
in
straightforward
formula,
and
possibility
retrospective
analysis.
Therefore,
ALPS
adopted
evaluate
system
for
many
disorders
studies.
The
purpose
this
review
look
back
discuss
at
moment.
Neurobiology of Disease,
Год журнала:
2024,
Номер
192, С. 106426 - 106426
Опубликована: Фев. 6, 2024
The
term
"glymphatic"
emerged
roughly
a
decade
ago,
marking
pivotal
point
in
neuroscience
research.
glymphatic
system,
glial-dependent
perivascular
network
distributed
throughout
the
brain,
has
since
become
focal
of
investigation.
There
is
increasing
evidence
suggesting
that
impairment
system
appears
to
be
common
feature
neurodegenerative
disorders,
and
this
exacerbates
as
disease
progression.
Nevertheless,
factors
contributing
dysfunction
across
most
disorders
remain
unclear.
Inflammation,
however,
suspected
play
role.
Dysfunction
can
lead
significant
accumulation
protein
waste
products,
which
trigger
inflammation.
interaction
between
inflammation
cyclical
potentially
synergistic.
Yet,
current
research
limited,
there
lack
comprehensive
models
explaining
association.
In
perspective
review,
we
propose
novel
model
inflammation,
impaired
function,
interconnected
vicious
cycle.
By
presenting
experimental
from
existing
literature,
aim
demonstrate
that:
(1)
aggravates
dysfunction,
(2)
exacerbated
progression,
(3)
progression
promotes
Finally,
implication
proposed
discussed.
NMR in Biomedicine,
Год журнала:
2024,
Номер
37(9)
Опубликована: Май 7, 2024
Abstract
Cerebrospinal
fluid
(CSF)
plays
a
critical
role
in
metabolic
waste
clearance
from
the
brain,
requiring
its
circulation
throughout
various
brain
pathways,
including
ventricular
system,
subarachnoid
spaces,
para‐arterial
interstitial
and
para‐venous
spaces.
The
complexity
of
CSF
has
posed
challenge
obtaining
noninvasive
measurements
dynamics.
assessment
dynamics
circulatory
pathways
is
possible
using
diffusion
magnetic
resonance
imaging
(MRI)
with
optimized
sensitivity
to
incoherent
water
movement
across
brain.
This
review
presents
an
overview
both
established
emerging
MRI
techniques
designed
measure
their
potential
clinical
applications.
discussion
offers
insights
into
optimization
acquisition
parameters
enhance
specificity
metrics
on
underlying
Lastly,
we
emphasize
importance
cautious
interpretations
diffusion‐based
imaging,
especially
when
differentiating
between
tissue‐
fluid‐related
changes
or
elucidating
structural
versus
functional
alterations.
Abstract
Objective
This
study
was
undertaken
to
investigate
the
regional
burden
of
enlarged
perivascular
spaces
(EPVSs)
in
patients
with
temporal
lobe
epilepsy
hippocampal
sclerosis
(TLE‐HS)
and
explore
its
prognostic
relevance.
Methods
In
this
retrospective
observational
study,
EPVSs
(T‐EPVS),
centrum
semiovale
(CS‐EPVS),
basal
ganglia
(BG‐EPVS),
midbrain,
hippocampus
were
visually
rated
68
treatment‐naïve
TLE‐HS.
Regional
EPVS
dichotomized
into
high
low
degrees
(cutoff:
>10
for
BG‐EPVS/T‐EPVS;
>20
CS‐EPVS).
Cox
proportional
hazards
models
used
determine
potential
predictors
seizure
freedom
(SF;
no
>1
year)
delayed
SF
(SF
achieved
>6
months
after
initiating
antiseizure
medication
[ASM]).
Multivariate
logistic
regression
using
stepwise
variable
selection
based
on
Akaike
information
criterion
performed
whether
associated
medical
refractoriness
(never
achieving
SF).
Results
Of
patients,
20
classified
refractory
group
(29.4%).
The
T‐EPVS
had
an
older
onset
(37.3
±
12.3
vs.
26.5
13.0
years,
p
=
.005),
higher
pretreatment
density
(median
12.0,
interquartile
range
[IQR]
5.0–20.0
4.0,
IQR
2.0–10.5,
.008),
lower
focal
bilateral
tonic–clonic
prevalence
(13.3%
73.6%,
<
.001)
than
group.
High
(odds
ratio
[OR]
10.908,
95%
confidence
interval
[CI]
1.895–62.789)
independent
predictor
medial
refractoriness,
along
female
sex
(OR
12.906,
CI
2.214–75.220)
ASM
treatment
duration
.985,
.971–.999).
probability
(
Log‐rank
.030,
.038),
whereas
comparable
between
two
groups
.053,
.146).
Significance
Increased
may
serve
as
imaging
marker
unfavorable
prognosis
TLE‐HS,
underscoring
role
dysfunction
diminished
response.
European Journal of Neurology,
Год журнала:
2023,
Номер
31(1)
Опубликована: Окт. 12, 2023
We
aimed
to
evaluate
(i)
glymphatic
system
function
in
patients
with
focal
epilepsy
comparison
healthy
controls,
and
(ii)
the
association
between
anti-seizure
medication
(ASM)
response
by
using
diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS).
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Дек. 8, 2023
Objective
This
study
aimed
to
evaluate
the
glymphatic
system
in
childhood
absence
epilepsy
(CAE)
using
diffusion
tensor
image
analysis
along
paravascular
space
(DTI-ALPS)
index.
Methods:
Forty-two
CAE
patients
and
50
age-
gender-matched
healthy
controls
(HC)
were
included
this
study.
All
participants
underwent
scanning
a
Siemens
3.0
T
magnetic
resonance
scanner,
DTI-ALPS
index
was
calculated.
The
compared
differences
of
between
controls.
Additionally,
also
assessed
relationship
clinical
characteristics
such
as
age,
seizure
frequency,
duration
epilepsy.
Results
lower
(1.45
±
0.36
vs.
1.66
0.30,
p
<
0.01).
showed
negative
correlation
with
(
r
=
−0.48,
0.01)
positive
age
0.766,
patients.
However,
no
significant
observed
frequency.
Conclusion
results
indicate
that
children
exhibit
dysfunction
brain,
which
might
contribute
understanding
pathophysiological
mechanism
CAE.
DTI-ALPS,
non-invasive
diagnostic
marker,
can
be
used
assess
function
patients,
providing
promising
applications
diagnosis
research
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Июнь 3, 2025
Pediatric
epilepsy
affects
a
large
proportion
of
children,
with
huge
variability
in
seizure
onset.
Due
to
complicated
etiology,
wide
range
associated
comorbidities,
and
difficulty
obtaining
clear
physiological
data
from
management
pediatric
patients
often
poses
critical
challenge.
Importantly,
around
30%
these
remain
non-responsive
current
anti-seizure
drugs
develop
higher
risk
developmental
cognitive
delay
and,
worse
situations,
premature
death.
One
the
key
treatment
methods
currently
used
for
drug-resistant
epilepsies
is
surgical
resection
epileptic
foci.
However,
such
new
foci
post-surgery.
This,
turn,
enhances
need
recurrent
invasive
brain
surgeries,
impairing
overall
quality
life
children.
Thus,
mechanistic
understanding
different
types
discovering
more
targeted
molecular
approach(es).
For
long
time,
occurrence
was
considered
solely
due
abnormal
functioning
single
ion
channels.
recent
years,
number
genetic
non-genetic
(environmental)
factors
have
been
epilepsy.
Clinical
diagnoses,
coupled
basic
cellular
mechanisms
using
model
systems,
instrumental
unraveling
avenues
modern
non-invasive
pharmacological
therapies.
Yet,
field
has
just
started
evolve,
many
challenges
contradictory
hypotheses
still
exist.
This
comprehensive
review
discusses
underlying
Specifically,
we
highlight
how
PI3K-AKT–MTOR
pathway
acts
as
node
interconnecting
diverse
strategies,
that
may
eventually
help
overcome
burden
future.