Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease

Journal of Neuroradiology, Год журнала: 2025, Номер 52(3), С. 101322 - 101322

Опубликована: Янв. 31, 2025

Язык: Английский

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Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Understanding how sleep affects the glymphatic system and human brain networks is crucial for elucidating neurophysiological mechanism underpinning aging-related memory declines. We analyzed a multimodal dataset collected through magnetic resonance imaging (MRI) polysomnographic recording from 72 older adults. A proxy of functioning was obtained Diffusion Tensor Image Analysis along Perivascular Space (DTI-ALPS) index. Structural functional were constructed based on MRI data, coupling between two (SC-FC coupling) also calculated. Correlation analyses revealed that DTI-ALPS negatively correlated with quality measures [e.g., Pittsburgh Sleep Quality Index (PSQI) apnea-hypopnea index]. Regarding networks, associated strength both connectivity (FC) structural (SC) involving regions such as middle temporal gyrus parahippocampal gyrus, well SC-FC rich-club connections. Furthermore, we found positively mediated association coupling. The further function in good sleepers but not poor sleepers. results suggest disrupted glymphatic-brain relationship sleepers, which underlies decline. Our findings add important evidence cognitive health underlying neural relationships interplay networks.

Язык: Английский

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Alterations in the Glymphatic System and Presence of Small Vessel Disease in Hospitalized and Non-hospitalized COVID Patients: A Study of PSMD Index and DTI-ALPS

Academic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease

Movement Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (m HTT ), comprising 35 manifest (mHD) 14 pre‐manifest (PreHD), healthy controls (HC) were recruited this study. diffusion along perivascular spaces (ALPS) index the percentage of space basal ganglia (pPVS_BG) obtained different groups. discrimination effects ALPS detected using receiver operating characteristic (ROC) analysis, correlations features HD further analyzed. Results decreased m carriers compared HCs, it lower mHD PreHD patients. ROC analysis showed that could discriminate from HC (AUC [area under curve] = 0.903), 0.886), 0.755). Lower correlated greater burden, severity disease, lager pPVS_BG, brain volume thickness cortices. Regression predict performance motor cognitive functions. Mediation revealed partially mediated CAG repeat age on decline HD. Conclusions This study demonstrated impairment system, especially paraventricular white matter BG, manifestations, structural changes carriers. © 2025 Author(s). Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Язык: Английский

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Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(4)

Опубликована: Апрель 1, 2025

Abstract Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading dementia and stroke. While the pathogenesis of SVD remains unclear, emerging evidence suggests that waste clearance involving perivascular space (PVS) – also known glymphatic system dysfunction may play role. Among radiological markers, increased presence dilated PVS marker disruption. Recently developed neuroimaging methods have been proposed indirect measures brain fluid dynamics, but they currently lack formal validation. Here, we provide comprehensive overview latest advancements for assessing including function in SVD. We review mechanisms by which might contribute Finally, argue robust, multimodal, longitudinal studies are essential understanding (involving PVS) establishing diagnostic gold standard. Highlights The majority not visible on MRI, making it crucial understand how why become dilated. origin disruption be multifactorial. BBB likely affect each other, forming vicious cycle, promoting further amyloid beta accumulation. Yet their direct association humans over time studied. Comparative can aid standardization function.

Язык: Английский

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DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 22, 2024

Backgrounds Type 2 Diabetes Mellitus (T2DM) has become a significant global public health issue, characterized by rising prevalence and associated deficits across multiple organ systems. Our study aims to utilize the DTI-ALPS technique assess change of ALPS index in T2DM patients, explore whether such changes are correlated with cognition level diffusion parameters. Methods The involved 41 patients (mean age, 60.49 ± 8.88 years) 27 healthy controls 58.00 7.63 years). All subjects underwent MRI examination, cognitive assessment, laboratory tests. Tract-based spatial statistics (TBSS) was used evaluate white matter changes. GLM performed check difference between HC groups. Spearman correlation analysis partial were analyze properties & scores. Results results show that lower patients. MoCA score significantly index. Patients had increase both mean diffusivity (MD) radial (RD) decrease fractional anisotropy (FA) compared group. Conclusion suggest is decreased associates level.

Язык: Английский

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Glymphatic system dysfunction in epilepsy related to focal cortical dysplasia and its relationship with antiseizure medication response

Seizure, Год журнала: 2025, Номер 125, С. 31 - 36

Опубликована: Янв. 1, 2025

Язык: Английский

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Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct

Neuroradiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Relationships Between Glymphatic System Activity and Tau Burden, Dopaminergic Impairment, Abnormal Glucose Metabolism in Progressive Supranuclear Palsy

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by dopaminergic impairment and abnormal glucose metabolism. The glymphatic system can promote the elimination of tau protein. association between function pathological hallmark in neuroimaging remains unknown. Methods Diffusion tensor imaging (DTI) positron emission tomography (PET) scanning with 18 F‐Florzolotau, F‐FPCIT, F‐FDG were performed PSP patients. DTI analysis along perivascular space (ALPS) index was computed to assess function, while semi‐quantitative value employed measure burden impairment. PSP‐related pattern (PSPRP) served as an indicator metabolic brain network activity. Results patients exhibited changes ALPS deposition. index, deposition, PSPRP expression showed significant correlations clinical scores. Additionally, correlated deposition expression. However, neither nor scores striatum dysfunction. Finally, subcortical regions mediating effects Conclusion dysfunction associated activity independent PSP.

Язык: Английский

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Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain

Journal of Pain, Год журнала: 2025, Номер unknown, С. 105356 - 105356

Опубликована: Март 1, 2025

Язык: Английский

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