Food Bioscience, Год журнала: 2024, Номер unknown, С. 105775 - 105775
Опубликована: Дек. 1, 2024
Язык: Английский
Antioxidants, Год журнала: 2025, Номер 14(4), С. 492 - 492
Опубликована: Апрель 18, 2025
Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body introduced dietary sources smoking. Recent clinical animal studies have highlighted significant role various health conditions. These accumulate nearly all mammalian tissues associated with range diseases, including diabetes its complications, cardiovascular disease, neurodegeneration. This review summarizes major diseases linked to AGE accumulation, presenting both experimental evidence. The pathologies induced by share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, direct protein cross-linking. Interventions targeting AGE-related focus on inhibiting formation using synthetic natural antioxidants, as well intake lifestyle modifications. recognized risk factors that impact accelerate aging, particularly individuals hyperglycemia. Monitoring level implementing nutritional interventions help maintain overall reduce complications.
Язык: Английский
Процитировано
0
Journal of Food Protection, Год журнала: 2024, Номер unknown, С. 100426 - 100426
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
2
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Сен. 27, 2024
Chronic kidney disease affects 1 in 10 people globally, with a prevalence twenty times that of cancer. A subset individuals will progress to end-stage renal (ESRD) where replacement therapy is required maintain health. Cutaneous disease, including xerosis and pruritus, are endemic amongst patients ESRD. In the uraemia-associated immune deficiency ESRD, impaired circulating responses contribute increased infection risk poorer vaccination response. Clinical manifestations dysregulated adaptive immunity within skin have been well-described posited play role cutaneous features However, our understanding mechanisms by which affected uraemia relatively limited. We provide an overview how system impacted both directly indirectly uraemia, highlighting much work has extrapolated from often not evaluated compartment. identify knowledge gaps may be addressed future research. Ultimately, greater these pathways facilitate novel therapeutic approaches ameliorate widespread symptomatology
Язык: Английский
Процитировано
1
Nutrire, Год журнала: 2024, Номер 49(2)
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
1
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(12), С. 14351 - 14365
Опубликована: Дек. 20, 2024
Ultraviolet (UV) irradiation causes skin wrinkles and decreases elasticity. UV also increases binding between advanced glycation end products (AGEs) the receptor for AGEs (RAGE), resulting in increased inflammation activation of NF-κB. We evaluated whether fermented fish collagen (FC) could decrease photoaging via decreasing AGE–RAGE activity, which was associated with decreased TNF-α NF-κB levels UV-irradiated keratinocytes animal skin. In keratinocytes, activity secretion were increased, FC these. Additionally, attenuated by soluble RAGE (RAGE inhibitor) keratinocytes. levels, translocation Furthermore, expression matrix metalloproteinases 1/3/9, degrades fibers, Smad7, inhibits Smad2/3, Smad2/3 fiber accumulation. moisture conclusion, attenuate its downstream signals such as
Язык: Английский
Процитировано
1
Medicina, Год журнала: 2024, Номер 60(8), С. 1211 - 1211
Опубликована: Июль 26, 2024
(L.) Medic flower (AMf) exhibits both nutritional value and bioactivities such as antioxidative, anti-inflammatory, neuroprotective, cardioprotective, hepatoprotective effects. The aim of this investigation was to examine the potential impact three different solvent extracts AMf: supercritical CO
Язык: Английский
Процитировано
0
Advances in chemical and materials engineering book series, Год журнала: 2024, Номер unknown, С. 335 - 354
Опубликована: Окт. 25, 2024
This chapter discusses natural compounds recognized for their antiaging properties and describes the underlying mechanisms of action, providing a concise synopsis studies on efficacy herbal extracts in products. The potential certain extracts, such as green tea, ginkgo, licorice, Aloe vera, ginseng, treating various signs aging has been investigated response to growing demand alternatives. Their which primarily target antioxidant defense, collagen production, cellular repair, explain how they reduce oxidative stress, improve skin elasticity, promote rejuvenation. then future trends issues proposes solutions.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2024, Номер unknown, С. 105775 - 105775
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0