Knockdown of GSDMD inhibits pyroptosis in psoriasis by blocking the NOD-like receptor signaling pathway
International Immunopharmacology,
Год журнала:
2025,
Номер
147, С. 114036 - 114036
Опубликована: Янв. 7, 2025
Язык: Английский
Non-coding RNAs modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142865 - 142865
Опубликована: Апрель 1, 2025
Язык: Английский
Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12522 - 12522
Опубликована: Ноя. 21, 2024
Steroids,
which
are
often
used
to
treat
the
inflammation
associated
with
various
skin
diseases,
have
several
negative
side
effects.
As
Ecklonia
cava
extract
has
anti-inflammatory
effects
in
we
evaluated
efficacy
of
cava-derived
extracellular
vesicles
(EVEs)
decreasing
12-O-tetradecanoylphorbol-13-acetate
(TPA)-induced
inflammation.
We
determined
effect
EVEs
on
TLR4/NF-κB/NLRP3
inflammasome
human
keratinocytes
and
mouse
ear
skin.
TPA-treated
showed
an
increased
expression
TLR4
its
ligands
HMGB1
S100A8.
TPA
also
(1)
NF-κB;
(2)
NLRP3
components
NLRP3,
ASC,
caspase
1;
(3)
pyroptosis-related
factors
GSDMD-NT,
IL-18,
IL-1β.
However,
these
molecules
decreased
after
EVE
treatment.
Similar
vitro
results,
skin,
treatment
their
expression.
The
edema,
redness,
neutrophil
infiltration,
epidermal
thickness,
reduced
symptoms
In
conclusion,
TPA-induced
inflammation,
was
a
decrease
inflammasome.
Язык: Английский
Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 10047 - 10064
Опубликована: Ноя. 1, 2024
Atopic
dermatitis
(AD)
is
a
common
pediatric
skin
disease,
with
recent
studies
suggesting
role
for
ferroptosis
in
its
pathogenesis.
Sodium
propionate
(SP)
has
shown
therapeutic
potential
AD,
yet
mechanism,
particularly
regarding
modulation,
remains
unclear.
This
study
aims
to
explore
whether
SP
alleviates
AD
by
modulating
ferroptosis-related
pathways
through
bioinformatic
and
vitro
analyses.
Язык: Английский
Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1349 - 1349
Опубликована: Окт. 23, 2024
Obstructive
sleep
apnea
(OSA)
is
a
common
respiratory
disorder,
primarily
characterized
by
two
pathological
features:
chronic
intermittent
hypoxia
(CIH)
and
deprivation
(SD).
OSA
has
been
identified
as
risk
factor
for
numerous
diseases,
the
inflammatory
response
related
to
programmed
cell
necrosis
believed
play
significant
role
in
occurrence
progression
of
multisystem
damage
induced
OSA,
with
increasing
attention
being
paid
pyroptosis.
Recent
studies
have
indicated
that
can
elevate
oxidative
stress
levels
body,
activating
process
pyroptosis
within
different
tissues,
ultimately
accelerating
organ
dysfunction.
However,
molecular
mechanisms
remain
unclear.
Therefore,
this
review
focuses
on
four
major
systems
received
concentrated
existing
research
order
explore
promoting
renal
cardiovascular
neurocognitive
skin
diseases
patients.
Furthermore,
we
provide
comprehensive
overview
methods
inhibiting
at
levels,
goal
identifying
viable
targets
therapeutic
strategies
addressing
OSA-related
complications.
Язык: Английский