IUPHAR Review: Eating Disorders, Gut Microbiota Dysbiosis and Epigenetic Aberrations
Pharmacological Research,
Год журнала:
2025,
Номер
213, С. 107653 - 107653
Опубликована: Фев. 17, 2025
Eating
disorders
(EDs)
are
a
heterogeneous
class
of
increasing
mental
that
characterized
by
disturbances
in
eating
behaviors,
body
weight
regulation,
and
associated
psychological
dysfunctions.
These
create
physiological
imbalances
alter
the
diversity
composition
gut
microbiota.
While
evidence
suggests
EDs
can
arise
from
epigenetic
aberrations,
alterations
microbial
communities
may
also
contribute
to
development
and/or
persistence
through
mechanisms.
Understanding
interplay
among
communities,
processes,
risk
provides
opportunities
for
designing
preventive
therapeutic
interventions
microbiome
modulation.
This
review
highlights
how
microbiome-based
therapeutics
specific
dietary
improving
various
subtypes
modulating
mitigating
aberrations.
First,
we
briefly
literature
on
links
between
aberrations
pathophysiology
EDs.
Second,
examine
potential
role
pathogenesis
Next,
explore
associations
other
psychiatric
disorders,
roles
their
pathogenesis.
Finally,
present
supporting
improve
modifications.
Язык: Английский
Gut microbiota: our fellow travellers in health & disease
FEBS Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
last
two
decades
have
seen
a
major
increase
in
our
understanding
of
the
role
microbiome
health
and
disease.
We
now
realise
that
these
fellow
travellers
are
really
important
regulators
various
systems
body
across
lifespan.
In
this
Special
Issue,
we
bring
together
collection
articles
from
leading
authors
who
summarise
current
state
art
host-microbe
interactions.
While
celebrate
breakthroughs
science,
also
acknowledge
challenges-variability
microbiota
composition,
complexities
interactions
need
for
standardised
methodologies.
As
research
progresses,
harnessing
power
may
pave
way
novel
diagnostic
therapeutic
strategies,
reaffirming
notion
never
alone-our
microbial
accompany
us
through
life,
better
or
worse.
Язык: Английский
Endocrine gastroenterological aspects of metabolic dysfunction
Experimental and Clinical Gastroenterology,
Год журнала:
2025,
Номер
9, С. 36 - 43
Опубликована: Март 6, 2025
This
review
article
examines
the
endocrine
gastroenterological
aspects
of
metabolic
dysfunction,
which
is
a
complex
pathological
condition
that
affects
metabolism
and
accompanied
by
disturbances
in
functioning
system.
The
introduction
focuses
on
key
hormones
such
as
insulin
leptin
their
roles
regulating
digestive
processes.
consequences
secretion
these
hormones,
including
development
type
2
diabetes
mellitus
obesity,
are
discussed.
offers
comprehensive
analysis
relationship
between
disruption
problems
irritable
bowel
syndrome,
highlighting
importance
further
research
to
understand
mechanisms
underlying
diseases.
results
this
can
serve
basis
for
new
approaches
diagnosis
treatment
disorders,
well
formation
strategies
prevention
associated
Язык: Английский
Effect of High-Fat Diet and Lactiplantibacillus plantarum 299v on the Gut Microbiome of Adolescent and Adult Rats
Obesities,
Год журнала:
2025,
Номер
5(1), С. 17 - 17
Опубликована: Март 16, 2025
Childhood
and
adolescent
obesity
its
associated
morbidities
are
increasing
in
part
due
to
the
ingestion
of
diets
high
fat
(HFD).
Changes
gastrointestinal
microbiome
have
been
with
these
morbidities,
including
insulin
resistance,
cardiovascular
disease,
inflammatory
states.
The
use
dietary
probiotics
may
mitigate
microbiome-associated
improve
health
during
maturation.
Using
our
established
model
rats
consuming
an
HFD
from
weaning,
we
examined
gut
a
single-strain
probiotic
drinking
water
[Lactiplantibacillus
plantarum
299v
(Lp299v,
LP299V®)]
adult
rats.
Our
main
finding
was
differential
effect
on
that
maturation
(adolescence
vs.
adulthood).
Specifically,
treatment
led
alterations
enrichment
microbiome,
which
were
obesity,
while
under
same
conditions
exhibited
minimal
changes,
demonstrating
differences
plasticity
Of
particular
relevance
this
regard
is
fact
Oscillospiraceae
Lachnospiraceae,
beneficial
short-chain
fatty
acid
production,
enriched
treated
Lp299v.
data
suggest
childhood
adolescence
adulthood
by
potentially
affecting
developing
microbiome.
Язык: Английский
Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches
Food and Agricultural Immunology,
Год журнала:
2025,
Номер
36(1)
Опубликована: Апрель 20, 2025
Язык: Английский
Microbiome and Phageome: Key Factors in Host Organism Function and Disease Prevention in the Context of Microbiome Transplants
Applied Sciences,
Год журнала:
2025,
Номер
15(10), С. 5330 - 5330
Опубликована: Май 10, 2025
The
study
of
interactions
between
gut
microbiota
and
the
well-being
host
has
become
increasingly
popular
in
last
decades.
Growing
interest
microbiota–host
brought
attention
to
faecal
transplantation
(FMT)
as
a
clinically
effective,
though
still
debated,
therapeutic
approach.
This
review
discusses
how
limitations
characterisation
bacteriomes—particularly
interindividual
variation
methodological
inconsistencies—may
influence
outcomes
FMT.
concept
enterotypes
is
considered
framework
that
could
support
more
refined
stratification
donors
recipients,
offering
possible
route
toward
greater
precision
microbiota-based
interventions.
Further
on,
touches
on
subject
among
host,
bacteriome,
phageome—the
community
bacteriophages—with
specific
focus
presence
intriguing
distribution
patterns
crAssviruses.
final
chapters
are
dedicated
discussing
current
state
FMT
procedure
its
variations,
well
possibility
performing
virome
transplants
(FVTs)
potentially
safer
equally
efficient
alternative.
Язык: Английский
Exploring the Frontier: The Human Microbiome’s Role in Rare Childhood Neurological Diseases and Epilepsy
Brain Sciences,
Год журнала:
2024,
Номер
14(11), С. 1051 - 1051
Опубликована: Окт. 23, 2024
Emerging
research
into
the
human
microbiome,
an
intricate
ecosystem
of
microorganisms
residing
in
and
on
our
bodies,
reveals
that
it
plays
a
pivotal
role
maintaining
health,
highlighting
potential
for
microbiome-based
interventions
to
prevent,
diagnose,
treat,
manage
myriad
diseases.
The
objective
this
review
is
highlight
importance
microbiome
studies
enhancing
understanding
rare
genetic
epilepsy
related
neurological
disorders.
Studies
suggest
gut
acting
through
gut-brain
axis,
impacts
development
severity
epileptic
conditions
children.
Disruptions
microbial
composition
can
affect
neurotransmitter
systems,
inflammatory
responses,
immune
regulation,
which
are
all
critical
factors
pathogenesis
epilepsy.
This
growing
body
evidence
points
microbiome-targeted
therapies,
such
as
probiotics
or
dietary
modifications,
innovative
approaches
managing
By
harnessing
power
we
stand
develop
more
effective
personalized
treatment
strategies
children
affected
by
disease
other
Язык: Английский