Exploring the Frontier: The Human Microbiome’s Role in Rare Childhood Neurological Diseases and Epilepsy DOI Creative Commons
Newell Belnap, Keri Ramsey,

Sophia T. Carvalho

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1051 - 1051

Published: Oct. 23, 2024

Emerging research into the human microbiome, an intricate ecosystem of microorganisms residing in and on our bodies, reveals that it plays a pivotal role maintaining health, highlighting potential for microbiome-based interventions to prevent, diagnose, treat, manage myriad diseases. The objective this review is highlight importance microbiome studies enhancing understanding rare genetic epilepsy related neurological disorders. Studies suggest gut acting through gut-brain axis, impacts development severity epileptic conditions children. Disruptions microbial composition can affect neurotransmitter systems, inflammatory responses, immune regulation, which are all critical factors pathogenesis epilepsy. This growing body evidence points microbiome-targeted therapies, such as probiotics or dietary modifications, innovative approaches managing By harnessing power we stand develop more effective personalized treatment strategies children affected by disease other

Language: Английский

IUPHAR Review: Eating Disorders, Gut Microbiota Dysbiosis and Epigenetic Aberrations DOI Creative Commons
Shabnam Nohesara, Hamid M. Abdolmaleky, Giuseppe Pettinato

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107653 - 107653

Published: Feb. 17, 2025

Eating disorders (EDs) are a heterogeneous class of increasing mental that characterized by disturbances in eating behaviors, body weight regulation, and associated psychological dysfunctions. These create physiological imbalances alter the diversity composition gut microbiota. While evidence suggests EDs can arise from epigenetic aberrations, alterations microbial communities may also contribute to development and/or persistence through mechanisms. Understanding interplay among communities, processes, risk provides opportunities for designing preventive therapeutic interventions microbiome modulation. This review highlights how microbiome-based therapeutics specific dietary improving various subtypes modulating mitigating aberrations. First, we briefly literature on links between aberrations pathophysiology EDs. Second, examine potential role pathogenesis Next, explore associations other psychiatric disorders, roles their pathogenesis. Finally, present supporting improve modifications.

Language: Английский

Citations

0
Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches DOI Creative Commons
Rosario Suárez, Estefanía Bautista-Valarezo, Andri Matos

et al.

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 20, 2025

Language: Английский

Citations

0
Gut microbiota: our fellow travellers in health & disease DOI Open Access
John F. Cryan

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The last two decades have seen a major increase in our understanding of the role microbiome health and disease. We now realise that these fellow travellers are really important regulators various systems body across lifespan. In this Special Issue, we bring together collection articles from leading authors who summarise current state art host-microbe interactions. While celebrate breakthroughs science, also acknowledge challenges-variability microbiota composition, complexities interactions need for standardised methodologies. As research progresses, harnessing power may pave way novel diagnostic therapeutic strategies, reaffirming notion never alone-our microbial accompany us through life, better or worse.

Language: Английский

Citations

0
Endocrine gastroenterological aspects of metabolic dysfunction DOI Creative Commons

T. I. Chernyadyeva,

Roman Bontsevich, О. В. Гаус

et al.

Experimental and Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: 9, P. 36 - 43

Published: March 6, 2025

This review article examines the endocrine gastroenterological aspects of metabolic dysfunction, which is a complex pathological condition that affects metabolism and accompanied by disturbances in functioning system. The introduction focuses on key hormones such as insulin leptin their roles regulating digestive processes. consequences secretion these hormones, including development type 2 diabetes mellitus obesity, are discussed. offers comprehensive analysis relationship between disruption problems irritable bowel syndrome, highlighting importance further research to understand mechanisms underlying diseases. results this can serve basis for new approaches diagnosis treatment disorders, well formation strategies prevention associated

Language: Английский

Citations

0
Effect of High-Fat Diet and Lactiplantibacillus plantarum 299v on the Gut Microbiome of Adolescent and Adult Rats DOI Creative Commons
Samantha N. Atkinson, Caron Dean,

Victoria L. Woyach

et al.

Obesities, Journal Year: 2025, Volume and Issue: 5(1), P. 17 - 17

Published: March 16, 2025

Childhood and adolescent obesity its associated morbidities are increasing in part due to the ingestion of diets high fat (HFD). Changes gastrointestinal microbiome have been with these morbidities, including insulin resistance, cardiovascular disease, inflammatory states. The use dietary probiotics may mitigate microbiome-associated improve health during maturation. Using our established model rats consuming an HFD from weaning, we examined gut a single-strain probiotic drinking water [Lactiplantibacillus plantarum 299v (Lp299v, LP299V®)] adult rats. Our main finding was differential effect on that maturation (adolescence vs. adulthood). Specifically, treatment led alterations enrichment microbiome, which were obesity, while under same conditions exhibited minimal changes, demonstrating differences plasticity Of particular relevance this regard is fact Oscillospiraceae Lachnospiraceae, beneficial short-chain fatty acid production, enriched treated Lp299v. data suggest childhood adolescence adulthood by potentially affecting developing microbiome.

Language: Английский

Citations

0
Exploring the Frontier: The Human Microbiome’s Role in Rare Childhood Neurological Diseases and Epilepsy DOI Creative Commons
Newell Belnap, Keri Ramsey,

Sophia T. Carvalho

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1051 - 1051

Published: Oct. 23, 2024

Emerging research into the human microbiome, an intricate ecosystem of microorganisms residing in and on our bodies, reveals that it plays a pivotal role maintaining health, highlighting potential for microbiome-based interventions to prevent, diagnose, treat, manage myriad diseases. The objective this review is highlight importance microbiome studies enhancing understanding rare genetic epilepsy related neurological disorders. Studies suggest gut acting through gut-brain axis, impacts development severity epileptic conditions children. Disruptions microbial composition can affect neurotransmitter systems, inflammatory responses, immune regulation, which are all critical factors pathogenesis epilepsy. This growing body evidence points microbiome-targeted therapies, such as probiotics or dietary modifications, innovative approaches managing By harnessing power we stand develop more effective personalized treatment strategies children affected by disease other

Language: Английский

Citations

0