Sphingolipidoses: expanding the spectrum of α-synucleinopathies

Journal of Neural Transmission, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Although α-synuclein pathology is typically associated with Lewy body diseases and multiple systems atrophy, increasing evidence indicates that it also occurs in a group of lysosomal storage disorders termed sphingolipidoses caused by the incomplete degradation, subsequent accumulation, class lipids sphingolipids. Notably, number genes cause are risk for diseases, suggesting aetiological links between these distinct disorders. In present review, we discuss which has been reported: Gaucher disease, Krabbe metachromatic leukodystrophy, Tay-Sachs disease Anderson-Fabry describe characteristic clinical pathological features disorders, addition to Finally, evaluate mechanisms underlie rare particular attention how enzymatic deficiency, substrate or both, could contribute genesis implications this diseases.

Язык: Английский

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Alpha-synuclein in Parkinson’s disease: the debate that must go on

Parkinsonism & Related Disorders, Год журнала: 2025, Номер unknown, С. 107850 - 107850

Опубликована: Апрель 1, 2025

Язык: Английский

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