Sphingolipidoses: expanding the spectrum of α-synucleinopathies

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Although α-synuclein pathology is typically associated with Lewy body diseases and multiple systems atrophy, increasing evidence indicates that it also occurs in a group of lysosomal storage disorders termed sphingolipidoses caused by the incomplete degradation, subsequent accumulation, class lipids sphingolipids. Notably, number genes cause are risk for diseases, suggesting aetiological links between these distinct disorders. In present review, we discuss which has been reported: Gaucher disease, Krabbe metachromatic leukodystrophy, Tay-Sachs disease Anderson-Fabry describe characteristic clinical pathological features disorders, addition to Finally, evaluate mechanisms underlie rare particular attention how enzymatic deficiency, substrate or both, could contribute genesis implications this diseases.

Language: Английский

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Alpha-synuclein in Parkinson’s disease: the debate that must go on

Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 107850 - 107850

Published: April 1, 2025

Language: Английский

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