Differential modulation of freezing and 22-kHz USVs by shock intensity, tone-duration matching, and anxiety levels in rodent fear-conditioning paradigms
Learning & Behavior,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Exploring the combined neuroprotective effects of resveratrol and hesperidin in a scopolamine-induced rat model of cognitive impairment
Neuroscience,
Год журнала:
2025,
Номер
579, С. 54 - 68
Опубликована: Май 26, 2025
Язык: Английский
Decoding the language of fear: Unveiling objective and subjective indicators in rodent models through a systematic review and meta-analysis
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
157, С. 105537 - 105537
Опубликована: Янв. 11, 2024
Язык: Английский
ChAT::Cre transgenic rats show sex‐dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression
Sarah C. Tryon,
Iris M. Sakamoto,
Kris F. Kaigler
и другие.
Genes Brain & Behavior,
Год журнала:
2023,
Номер
22(1)
Опубликована: Янв. 13, 2023
Abstract
The
cholinergic
system
is
a
critical
regulator
of
Pavlovian
fear
learning
and
extinction.
As
such,
we
have
begun
investigating
the
system's
involvement
in
individual
differences
cued
extinction
using
transgenic
ChAT::Cre
rat
model.
current
study
extends
behavioral
phenotyping
line
by
examining
both
freezing
behavior
ultrasonic
vocalizations
(USVs)
during
paradigm.
Freezing,
22
kHz
USVs,
50
USVs
were
compared
between
male
female
ChAT::Cre+
rats
their
wildtype
(Cre‐)
littermates
learning,
contextual
cue‐conditioned
recall,
extinction,
generalization
to
novel
tone.
During
recall
froze
slightly
more
than
Cre‐
littermates,
displayed
significant
sex
freezing,
USVs.
Females
showed
males
trials,
but
fewer
distress
calls
recall.
also
produced
exposure
testing
chambers
prior
tone
(or
shock)
presentation
with
males,
this
effect
was
blunted
females.
Corroborating
previous
studies,
overexpressed
vesicular
acetylcholine
transporter
immunolabeling
basal
forebrain,
striatum,
basolateral
amygdala,
hippocampus,
had
similar
levels
acetylcholinesterase
numbers
ChAT+
neurons
as
rats.
This
suggests
that
variance
dependent
advances
theories
distinct
neural
circuits
processes
regulate
sexually
divergent
responses.
Язык: Английский
Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Mllt11
(myeloid/lymphoid
or
mixed-lineage
leukemia
translocated
to
chromosome
11;
also
known
as
Af1q/TcF7c)
has
been
identified
a
novel
regulator
of
neural
development,
playing
role
in
the
migration
and
outgrowth
cortical
projection
neurons.
We
previously
reported
that
conditional
inactivation
gene
mouse
superficial
cortex
resulted
reduced
connectivity
corpus
callosum
white
fiber
tracts,
resulting
thickness.
However,
behavioral
consequences
loss
are
unknown.
Callosal
abnormalities
thought
be
present
3-5%
all
neurodevelopmental
disorders
volume
correlates
with
core
symptoms
autism
spectrum
disorder
(ASD)
humans.
Cortical
thickness
dysregulation
is
likewise
shared
among
various
including
ASD.
therefore
investigated
knockout
upper
layer
2/3
neurons
using
transgenic
Cux2iresCre
mice.
Utilizing
tasks
designed
reflect
ASD
symptoms,
we
examined
behaviors
both
male
female
animals.
These
tests
included
olfaction
habituation/dishabituation,
three-chambered
social
approach,
marble
burying,
nestlet
shredding.
found
sex-dependent
disruptions
preference,
shredding
animals
lacking
Mllt11,
mice
presenting
more
than
males.
Understanding
phenotype
associated
genes
interest
specifically
context
sex
differences
crucial
individualized
treatment
for
disorders.
Язык: Английский