Beyond dichotomy: diversity of rat's ultrasonic vocalizations DOI Open Access
Reo Wada, Shiomi Hakataya, Ryosuke O. Tachibana

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Ultrasonic vocalizations (USVs) in rats have been established as an ideal model for studying emotional expression because they reflect internal states. Since the discovery of USVs rats, it has gradually revealed that two types adult rats' with distinct acoustic features (high-short and low-long) are closely linked to positive negative affect, respectively. Thus, many years, most studies grouped into dichotomous categories: 50-kHz (positive) 22-kHz (negative) USVs, using these numbers labels rather than measured values. However, diversity may overlooked due this 50- / framework, several recent claim found new categories outside framework. Here, through a systematic survey descriptions past literature, we confirmed non-negligible number reports on Our results support abundance diverse beyond dichotomy. This extends traditional association between states, highlighting importance research might complex affective states simple distinction negative.

Language: Английский

Differential modulation of freezing and 22-kHz USVs by shock intensity, tone-duration matching, and anxiety levels in rodent fear-conditioning paradigms DOI

Benhuiyuan Zheng,

J. Murti Rao, Lili Bao

et al.

Learning & Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
ChAT::Cre transgenic rats show sex‐dependent altered fear behaviors, ultrasonic vocalizations and cholinergic marker expression DOI Creative Commons

Sarah C. Tryon,

Iris M. Sakamoto,

Kris F. Kaigler

et al.

Genes Brain & Behavior, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 13, 2023

Abstract The cholinergic system is a critical regulator of Pavlovian fear learning and extinction. As such, we have begun investigating the system's involvement in individual differences cued extinction using transgenic ChAT::Cre rat model. current study extends behavioral phenotyping line by examining both freezing behavior ultrasonic vocalizations (USVs) during paradigm. Freezing, 22 kHz USVs, 50 USVs were compared between male female ChAT::Cre+ rats their wildtype (Cre‐) littermates learning, contextual cue‐conditioned recall, extinction, generalization to novel tone. During recall froze slightly more than Cre‐ littermates, displayed significant sex freezing, USVs. Females showed males trials, but fewer distress calls recall. also produced exposure testing chambers prior tone (or shock) presentation with males, this effect was blunted females. Corroborating previous studies, overexpressed vesicular acetylcholine transporter immunolabeling basal forebrain, striatum, basolateral amygdala, hippocampus, had similar levels acetylcholinesterase numbers ChAT+ neurons as rats. This suggests that variance dependent advances theories distinct neural circuits processes regulate sexually divergent responses.

Language: Английский

Citations

5
Decoding the language of fear: Unveiling objective and subjective indicators in rodent models through a systematic review and meta-analysis DOI
Lili Bao, J. Murti Rao, Delin Yu

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 157, P. 105537 - 105537

Published: Jan. 11, 2024

Language: Английский

Citations

1
Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice DOI Creative Commons
Emily A. Witt,

Danielle Stanton-Turcotte,

Pristine Garay

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Mllt11 (myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 11; also known as Af1q/TcF7c) has been identified a novel regulator of neural development, playing role in the migration and outgrowth cortical projection neurons. We previously reported that conditional inactivation gene mouse superficial cortex resulted reduced connectivity corpus callosum white fiber tracts, resulting thickness. However, behavioral consequences loss are unknown. Callosal abnormalities thought be present 3-5% all neurodevelopmental disorders volume correlates with core symptoms autism spectrum disorder (ASD) humans. Cortical thickness dysregulation is likewise shared among various including ASD. therefore investigated knockout upper layer 2/3 neurons using transgenic Cux2iresCre mice. Utilizing tasks designed reflect ASD symptoms, we examined behaviors both male female animals. These tests included olfaction habituation/dishabituation, three-chambered social approach, marble burying, nestlet shredding. found sex-dependent disruptions preference, shredding animals lacking Mllt11, mice presenting more than males. Understanding phenotype associated genes interest specifically context sex differences crucial individualized treatment for disorders.

Language: Английский

Citations

0
Beyond dichotomy: diversity of rat's ultrasonic vocalizations DOI Open Access
Reo Wada, Shiomi Hakataya, Ryosuke O. Tachibana

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Ultrasonic vocalizations (USVs) in rats have been established as an ideal model for studying emotional expression because they reflect internal states. Since the discovery of USVs rats, it has gradually revealed that two types adult rats' with distinct acoustic features (high-short and low-long) are closely linked to positive negative affect, respectively. Thus, many years, most studies grouped into dichotomous categories: 50-kHz (positive) 22-kHz (negative) USVs, using these numbers labels rather than measured values. However, diversity may overlooked due this 50- / framework, several recent claim found new categories outside framework. Here, through a systematic survey descriptions past literature, we confirmed non-negligible number reports on Our results support abundance diverse beyond dichotomy. This extends traditional association between states, highlighting importance research might complex affective states simple distinction negative.

Language: Английский

Citations

0