HIGH-INTENSITY BINGE DRINKING ACCENTUATES BONE DAMAGE IN INDUCED APICAL PERIODONTITIS IN RATS DOI Creative Commons
José Mario Matos-Souza, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos

и другие.

Heliyon, Год журнала: 2024, Номер 10(22), С. e40163 - e40163

Опубликована: Ноя. 1, 2024

This study aimed to evaluate the effects of excessive and episodic consumption ethanol (EtOH, a high-intensity drinking manner) on induced apical periodontitis in rats. Thirty-two animals were divided into following four groups: control, EtOH, periodontitis, EtOH + periodontitis. Ethanol exposure (3 g/kg 20 % w/v EtOH) was performed by orogastric gavage for 3 consecutive days, followed 4 days withdrawal weeks. Lesions exposing dental pulp lower first molar absence any treatment/curative 28 days. Finally, euthanized, mandibles collected. The mandible medially, with one hemimandible being used micro-computed tomography analysis volume periapical lesion bone quality parameters, such as trabecular assessments; other histological analysis, descriptive histopathological tissue pattern loss presented, well an assessment collagen content present. data subjected statistical (one-way variance Tukey's post-hoc test). Our results showed that group had larger lesions than not exposed ethanol. Additionally, parameters reduction thickening trabeculae, associated increased destruction reduced remnant region alveolar bone. These suggest alcohol is aggravating factor and, consequently, its progression, quantity remaining are modulating aspects.

Язык: Английский

Correlation between REDOX enzymes and NET markers expression during the development of periapical lesions in mice DOI
Clara Marina Pereira Cavalcanti Silva, Vivian Vicentin Massoni, Lisa Danielly Curcino Araújo

и другие.

Clinical Oral Investigations, Год журнала: 2025, Номер 29(3)

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
The prevalence and healing of apical periodontitis in patients with autoimmune diseases DOI Creative Commons
Francesco Mannocci, Garrit Koller, Sushmita Ravindran

и другие.

International Endodontic Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 2, 2025

Abstract Apical periodontitis (AP) is a common and clinically significant oral health condition, associated with an inflammatory response to infections within the root canal system. As patients retain natural teeth for longer, managing AP becomes more complex. Whilst generally effective, endodontic treatment outcomes can vary considerably in individuals systemic conditions, such as autoimmune diseases. The intersection of inflammation, immune dysfunction pharmacological treatments different diseases raises important questions about how influence prevalence healing. This article examines current evidence on this interplay, its clinical implications need tailored approaches

Язык: Английский

Процитировано

1
Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives DOI Creative Commons
He Liu, Ya Shen

International Endodontic Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Stimuli‐responsive hydrogels are smart and functional materials that respond to various environmental stimuli, including temperature, light, magnetic field, pH, redox, enzymes glucose. This responsiveness allows for the controlled release of therapeutic agents encapsulated within hydrogels, enhancing treatment precision, improving outcomes minimizing side effects. Such show great potential in root canal disinfection, management dental pulp inflammation regeneration, making them promising candidates more personalized effective endodontic treatments. article provides an overview latest advancements design application stimuli‐responsive endodontics, emphasizing their revolutionize It also addresses current challenges explores future directions aiming inspire motivate researchers further engage or intensify efforts this area research.

Язык: Английский

Процитировано

0
ZEB1 expression in Th17 cells correlated with p-STAT3 in human apical periodontitis DOI Creative Commons
Xiaoyue Sun, Jingwen Yang, Zijun Wang

и другие.

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 27, 2025

Abstract Background ZEB1, a zinc-finger E homeobox-binding transcription factor most frequently associated with developmental programs linked to epithelial-mesenchymal transition, has been demonstrated regulate immune cell function. The study aimed investigate the expression pattern of ZEB1 in Th17 cells and its colocalization p-STAT3 human apical periodontitis lesions. Methods Thirty-nine periapical tissues were collected for ex vivo study, including granulomas (PGs, n = 14), radicular cysts (RCs, 12), healthy control (control group, 13). Inflammatory infiltration lesions was assessed using hematoxylin-eosin staining. detected analyzed by immunohistochemistry. localization fluorescence colocalization. Results significantly higher PGs RCs than group; however no significant difference between two groups observed. Immunofluorescence analysis revealed that correlated IL17 CD4 double-positive ZEB1/ predominant group. Conclusions elevated RCs, expression. This is potential player STAT3 activation pathogenesis.

Язык: Английский

Процитировано

0
The interleukin gene landscape: understanding its influence on inflammatory mechanisms in apical periodontitis DOI

Tuqa Z. Omran,

Fatima Salem Obaid Al Jasmi,

Kawthar Mahdi Obaid

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Histological and immunohistochemical analysis of human periapical lesions: a study of TGF-β1 and CD68 markers DOI Creative Commons
Nermeen AbuBakr, Geraldine Ahmed, Amany Hany Mohamed Kamel

и другие.

BMC Oral Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Endodontic treatment modifies circulatory inflammatory mediator levels: A systematic review with meta‐analysis DOI Creative Commons
Aleksandar Jakovljević, Helena Fransson, Abdulaziz Bakhsh

и другие.

International Endodontic Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

There is limited and conflicting data on the reduction of circulatory inflammatory mediators in patients with apical periodontitis (AP) following endodontic treatment.

Язык: Английский

Процитировано

1
HIGH-INTENSITY BINGE DRINKING ACCENTUATES BONE DAMAGE IN INDUCED APICAL PERIODONTITIS IN RATS DOI Creative Commons
José Mario Matos-Souza, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos

и другие.

Heliyon, Год журнала: 2024, Номер 10(22), С. e40163 - e40163

Опубликована: Ноя. 1, 2024

This study aimed to evaluate the effects of excessive and episodic consumption ethanol (EtOH, a high-intensity drinking manner) on induced apical periodontitis in rats. Thirty-two animals were divided into following four groups: control, EtOH, periodontitis, EtOH + periodontitis. Ethanol exposure (3 g/kg 20 % w/v EtOH) was performed by orogastric gavage for 3 consecutive days, followed 4 days withdrawal weeks. Lesions exposing dental pulp lower first molar absence any treatment/curative 28 days. Finally, euthanized, mandibles collected. The mandible medially, with one hemimandible being used micro-computed tomography analysis volume periapical lesion bone quality parameters, such as trabecular assessments; other histological analysis, descriptive histopathological tissue pattern loss presented, well an assessment collagen content present. data subjected statistical (one-way variance Tukey's post-hoc test). Our results showed that group had larger lesions than not exposed ethanol. Additionally, parameters reduction thickening trabeculae, associated increased destruction reduced remnant region alveolar bone. These suggest alcohol is aggravating factor and, consequently, its progression, quantity remaining are modulating aspects.

Язык: Английский

Процитировано

0