Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients—Randomized Controlled Trial

Nutrients, Год журнала: 2023, Номер 15(5), С. 1234 - 1234

Опубликована: Фев. 28, 2023

COVID-19 symptoms vary from asymptomatic cases to moderate and severe illness with patients needing hospitalization intensive care treatment. Vitamin D is associated severity of viral infections has an immune-modulatory effect in immune response. Observational studies showed a negative association low vitamin levels mortality outcomes. In this study, we aimed determine whether daily supplementation during unit (ICU) stay affects clinically relevant Patients disease need respiratory support admitted the ICU were eligible for inclusion. randomized into one two groups: intervention group received control did not receive supplementation. total, 155 randomized: 78 77 group. There was no statistically significant difference number days spent on support, although trial underpowered main outcome. any secondary outcomes analyzed between groups. Our study suggests benefit

Язык: Английский

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Putative Role of Vitamin D for COVID-19 Vaccination

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(16), С. 8988 - 8988

Опубликована: Авг. 20, 2021

Severe acute respiratory syndrome coronavirus 2 is a new, highly pathogenic virus that has recently elicited global pandemic called the 2019 disease (COVID-19). COVID-19 characterized by significant immune dysfunction, which caused strong but unregulated innate immunity with depressed adaptive immunity. Reduced and delayed responses to interferons (IFN-I/IFN-III) can increase synthesis of proinflammatory cytokines extensive cell infiltration into airways, leading pulmonary disease. The development effective treatments for severe patients relies on our knowledge pathophysiological components this imbalanced response. Strategies address response factors will be essential. Significant efforts are currently underway develop vaccines against SARS-CoV-2. vaccines, such as inactivated DNA, mRNA, protein subunit have already been applied in clinical use. Various display different levels effectiveness, it important continue optimize update their composition order effectiveness. However, due continuous emergence variant viruses, improving general public may also effectiveness vaccines. Many observational studies demonstrated serum vitamin D inversely correlated incidence or severity COVID-19. Extensive evidence shown supplementation could vital mitigating progression reduce its severity. Vitamin defends SARS-CoV-2 through complex mechanism interactions between modulation reactions, ACE2 expression, inhibition renin-angiotensin system (RAS). remains unclear whether Vit-D plays an role Based analysis molecular involved, we speculated vit-D, via various signaling pathways, complementary vaccine efficacy.

Язык: Английский

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Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 112965 - 112965

Опубликована: Апрель 14, 2022

Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may acute respiratory distress syndrome (ARDS). Vitamin D favour anti-inflammatory environment improve cytotoxic against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved with pneumonia levels 25-hydroxyvitamin (25(OH)D) 14.8 ng/ml (SD: 6.18) test antiviral efficacy, tolerance safety 10,000 IU/day cholecalciferol (vitamin

Язык: Английский

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Consensus and Controversial Aspects of Vitamin D and COVID-19

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2022, Номер 108(5), С. 1034 - 1042

Опубликована: Дек. 8, 2022

Abstract Objective This work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, COVID-19. Methods The International Conferences “Controversies Vitamin D” are a series workshops that started 2017 featuring international experts leaders D research clinical practice. fifth annual conference was held Stresa, Italy, September 15 18, 2021. Evidence Before event, participants reviewed available studies on their assigned topic, drafted related abstract, presented findings at time conference. Relevant literature became since also discussed within panel updated accordingly. Consensus abstracts had been merged prepare preliminary document. After presentations, in-depth discussions open sessions led consensus. document subsequently modified according up-to-date inclusion. Conclusions There is quite consistent evidence for an association between low 25 OH (25(OH)D) levels poor COVID-19 outcomes, despite heterogeneous publications variable quality. However, status patients might reflect reverse causality. supplementation have positive role prevention. supporting beneficial effect treatment decreasing risk complications conflicting. Conclusive statements regarding this context await high-quality, randomized controlled trials.

Язык: Английский

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The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review

Journal of Health Population and Nutrition, Год журнала: 2024, Номер 43(1)

Опубликована: Янв. 29, 2024

Abstract Background and aims A healthy diet play an important role in the prevention even treatment of various diseases. Proper nutrition plays boosting immune system. These include consumption macronutrients such as proteins, lipids, carbohydrates, also micronutrients including vitamins. Here, we aimed to systematically review effects on COVID-19. Methods We searched databases PubMed, Scopus, Embase, Web Science December 23, 2023. The records were downloaded into EndNote file, duplicates removed, studies underwent a two-phase screening process based their title/abstracts full texts. included articles screened inclusion exclusion criteria. English systematic reviews meta-analyses that concurred with aim our study. selected assessed by Cochrane's Risk Bias Systematic Reviews for quality check. data eligible extracted pre-designed word table used qualitative synthesis. Results total 28 this Most have shown are effective morbidity mortality controlling viral respiratory infections COVID-19 but some sometimes not severity. On other hand, calcifediol was far most successful agent reducing intensive care needs between studies. Conclusion Individuals without malnutrition had reduced risk SARS-CoV-2 infection severe disease. administration Vitamin D is patients. Patients vitamin deficiency more prone experience infection, they at higher morbidities mortality. Other A, B, Zinc showed benefits patients C no efficacy management intravenous form or high doses.

Язык: Английский

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Insufficient evidence for vitamin D use in COVID‐19: A rapid systematic review

International Journal of Clinical Practice, Год журнала: 2021, Номер 75(11)

Опубликована: Июль 26, 2021

Vitamin D deficiency has been linked to the increased severity of numerous viral infections.

Язык: Английский

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Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июль 4, 2022

There is now sufficient evidence to support that vitamin D deficiency may predispose SARS-CoV-2 infection and increase COVID-19 severity mortality. It has been suggested 3 supplementation be used prophylactically as an affordable safe strategy could added the existing standard treatment. This multicenter, single-blinded, prospective randomized pilot clinical trial aimed evaluate safety, tolerability, effectiveness of 10,000 IU/day in comparison with 2000 cholecalciferol for 14 days reduce duration 85 hospitalized individuals. The median age participants was 65 years (Interquartile range (IQR): 53–74), most them (71%) were men mean baseline 25-hydroxyvitamin (25(OH)D) serum 15 ng/ml (standard deviation (SD):6). After supplementation, 25(OH)D levels significantly increased group who received 10,000IU/day ( p < 0.0001) n = 44) 2,000IU/day 41), especially overweight obese participants, higher dose well tolerated. A fraction individuals our cohort (10/85) developed acute respiratory distress syndrome (ARDS). length hospital stay these patients ARDS different assigned 4; 7 days; IQR: 4–13) 6; 27 12–45) 0.04). Moreover, inspired oxygen reduced 7.6-fold high 0.049). In terms blood parameters, we did not identify overall significant improvements, although platelet count showed a modest but difference those supplemented 0.0492). conclusion, administration association care during hospitalization safe, tolerable, beneficial, thereby helping improve prognosis recovery process.

Язык: Английский

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High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study—VitCov Trial

Trials, Год журнала: 2022, Номер 23(1)

Опубликована: Фев. 4, 2022

Abstract Background The coronavirus disease 19 (COVID-19) pandemic has caused millions of deaths, and new treatments are urgently needed. Factors associated with a worse COVID-19 prognosis include old age (> 65 years), ethnicity, male sex, obesity, people comorbidities. Furthermore, vitamin D deficiency was reported as predictor poor in patients acute respiratory failure due to COVID-19. According recent clinical case series, is modifiable risk factor, which the prospect reducing hospital stay, intensive care, fatal outcomes. Vitamin potent immunomodulatory properties, its supplementation might improve important outcomes critically ill D-deficient patients. Despite evidence that supports an association between severity, there uncertainty about direct link. Therefore, aim trial assess if high-dose therapeutic effect Methods As design, randomized, placebo-controlled, double-blind, multi-center approach chosen compare high single dose (140,000 IU) followed by treatment usual (TAU) (VitD + TAU) only (placebo deficiency. Discussion substitution should be investigated for efficacy safety. study test hypothesis suffering from treated under standardized conditions will recover faster when additionally supplementation. Latest studies suggest highly recommended positively influence course disease. With this randomized controlled trial, contribution guidelines shall made. Trial registration ClinicalTrials.gov NCT04525820 SNCTP 2020-01401

Язык: Английский

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Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

COVID-19 remains globally pandemic, and although several meta-analyses have explored the association between vitamin D relative to clinical outcomes, a unified view has not yet emerged. To summarize evidence for associations levels COVID-19-related outcomes assess strength validity of these associations. PubMed, Embase, Web Science, Scopus, Cochrane Database Systematic Reviews databases were searched from January 1, 2020, June 15, 2024. Two reviewers independently extracted data assessed study quality. Low increased risk infection by 1.26- 2.18-fold, severe illness 1.50- 5.57-fold, intensive care unit (ICU) admission more than 2-fold, death 1.22- 4.15-fold. In addition, patients with deficiency had an average increase in length hospital stay 0.54 days compared high levels. Overall, supplementation may reduce severity (eg, ICU admissions, need mechanical ventilation) shorter but nonsignificant effect on mortality rates. there significant differences individuals testing positive those negative (mean difference [MD] = -3.22 ng mL-1; 95% CI, -5.18 -1.25), cases mild (MD -4.60 -5.49 -3.71), nonsurvivors survivors -6.59 CI: -8.94 -4.24). are associated higher rates, disease, rates among COVID-19, whereas patients' disease severity. The beneficial effects remain be further explored, however, higher-quality, randomized controlled studies. Nonetheless, caution is warranted because methodological quality most level very low. PROSPERO registration No. CRD42022385036.

Язык: Английский

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Susceptibility to COVID-19 Nutrition Misinformation and Eating Behavior Change during Lockdowns: An International Web-Based Survey

Nutrients, Год журнала: 2023, Номер 15(2), С. 451 - 451

Опубликована: Янв. 14, 2023

To understand the susceptibility to nutrition-health misinformation related preventing, treating, or mitigating risk of COVID-19 during initial lockdowns around world, present international web-based survey study (15 April-15 May 2020) gauged participants' (

Язык: Английский

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