Dual Role of Indoles Derived From Intestinal Microbiota on Human Health

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 17, 2022

Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the barrier human intestine, which exert anti-inflammatory activities mainly through activating AhR PXR receptors affect immune system’s function, significantly improving health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) further promote (diabetes mellitus, central system inflammation, vascular regulation). However, revealed toxic influences cannot be ignored. Indoxyl sulfate, an derivative, performs nephrotoxicity cardiovascular toxicity. We addressed interaction between indoles’ effects on double-edged swords. This review provides scientific bases for correlation with diseases moreover highlights several directions subsequent indoles-related studies.

Язык: Английский

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Perinatal and Early-Life Nutrition, Epigenetics, and Allergy

Nutrients, Год журнала: 2021, Номер 13(3), С. 724 - 724

Опубликована: Фев. 25, 2021

Epidemiological studies have shown a dramatic increase in the incidence and prevalence of allergic diseases over last several decades. Environmental triggers including risk factors (e.g., pollution), loss rural living conditions farming conditions), nutritional status maternal, breastfeeding) are considered major contributors to this increase. The influences these environmental thought be mediated by epigenetic mechanisms which heritable, reversible, biologically relevant biochemical modifications chromatin carrying genetic information without changing nucleotide sequence genome. An important feature characterizing epigenetically-mediated processes is existence time frame where induced effects strongest therefore most crucial. This period between conception, pregnancy, first years life 1000 days) optimal for factors, such as nutrition, exert their beneficial effects. In current review, we discussed impact exposure bacteria, viruses, parasites, fungal components, microbiome metabolites, specific components polyunsaturated fatty acids (PUFA), vitamins, plant- animal-derived microRNAs, breast milk) on patterns related manifestations. We gave insight into signature bioactive milk nutrition neonatal T cell development. Several lines evidence suggest that atypical metabolic reprogramming extrinsic allergens, pollutants, diet, or might drive cellular dysfunctions defective immune responses disease. Therefore, described knowledge relationship immunometabolism allergy mechanisms. presented will give changes potential maternal post-natal development

Язык: Английский

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Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Ageing Research Reviews, Год журнала: 2021, Номер 68, С. 101323 - 101323

Опубликована: Март 23, 2021

Язык: Английский

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The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Molecular Medicine, Год журнала: 2021, Номер 27(1)

Опубликована: Апрель 1, 2021

Abstract Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, was identified numerous compartments, including the tumor tissue itself, upper and lower female genital tract, serum, peritoneum, intestines. Colonization linked Gram-negative bacteria with high inflammatory potential. Local inflammation probably participates initiation continuation of carcinogenesis. Furthermore, local bacterial colonies peritoneum may facilitate metastasis formation cancer. Vaginal infections (e.g. Neisseria gonorrhoeae or Chlamydia trachomatis ) increase risk developing Bacterial metabolites, produced healthy eubiome oncobiome, exert autocrine, paracrine, hormone-like effects, evidenced breast pancreas adenocarcinoma. We discuss possible involvement lipopolysaccharides, lysophosphatides tryptophan well as, short-chain fatty acids, secondary bile acids polyamines carcinogenesis applicability nutrients, antibiotics, probiotics harness microbiome support therapy. The oncobiome most likely metabolites play vital roles mediating effectiveness chemotherapy. Finally, we potential oncobiotic changes biomarkers for diagnosis microbial adjuvant agents

Язык: Английский

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Interactions between polysaccharides and gut microbiota: A metabolomic and microbial review

Food Research International, Год журнала: 2022, Номер 160, С. 111653 - 111653

Опубликована: Июль 10, 2022

Язык: Английский

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