Sepsis-Associated Encephalopathy and Blood-Brain Barrier Dysfunction

Inflammation, Год журнала: 2021, Номер 44(6), С. 2143 - 2150

Опубликована: Июль 21, 2021

Язык: Английский

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White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications

Advanced Healthcare Materials, Год журнала: 2021, Номер 11(7)

Опубликована: Авг. 31, 2021

White blood cells (WBCs) are immune that play essential roles in critical diseases including cancers, infections, and inflammatory disorders. Their dynamic diverse functions have inspired the development of WBC membrane-coated nanoparticles (denoted "WBC-NPs"), which formed by fusing plasma membranes WBCs, such as macrophages, neutrophils, T cells, natural killer onto synthetic nanoparticle cores. Inheriting entire source cell antigens, WBC-NPs act decoys simulate their broad biointerfacing properties with intriguing therapeutic potentials. Herein, recent medical applications focusing on four areas, carriers for drug delivery, countermeasures biological neutralization, nanovaccines modulation, tools isolation circulating tumor fundamental research is reviewed. Overall, studies established platform versatile nanotherapeutics application

Язык: Английский

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Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Biomedicines, Год журнала: 2023, Номер 11(2), С. 294 - 294

Опубликована: Янв. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Язык: Английский

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Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review

Tropical Medicine and Infectious Disease, Год журнала: 2024, Номер 9(1), С. 13 - 13

Опубликована: Янв. 4, 2024

Interleukins (ILs) are signaling molecules that crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of cells, whereas anti-inflammatory help suppress excessive inflammation promote tissue repair. Here, we provide a comprehensive overview role pro-inflammatory diseases, with focus on mechanisms underlying their effects, diagnostic therapeutic potential, emerging trends IL-based therapies.

Язык: Английский

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Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling

Pharmacological Research, Год журнала: 2022, Номер 185, С. 106473 - 106473

Опубликована: Сен. 28, 2022

Язык: Английский

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