Cell Membrane‐Anchoring Nano‐Photosensitizer for Light‐Controlled Calcium‐Overload and Tumor‐Specific Synergistic Therapy DOI
Min Gao,

Tianhao Yang,

Weiji Qin

и другие.

Small, Год журнала: 2022, Номер 18(48)

Опубликована: Сен. 30, 2022

Abstract Poor selectivity and unintended toxicity to normal organs are major challenges in calcium ion (Ca 2+ ) overload tumor therapy. To address this issue, a cell membrane‐anchoring nano‐photosensitizer (CMA‐nPS) is constructed for inducing tumor‐specific Ca through multistage endogenous homeostasis disruption under light guidance, i.e., the extracellular influx caused by membrane damage, followed intracellular imbalance mitochondrial dysfunction. CMA‐nPS decorated two types of functionalized membranes, azide‐modified macrophage used conjugate dibenzocyclooctyne‐decorated photosensitizer, vesicular stomatitis virus glycoprotein (VSV‐G)‐modified NIH3T3 guide anchoring photosensitizer lung cancer membrane. The vitro study shows that mainly anchors on membrane, further causes dysfunction, as well upon irradiation. Synergistically enhanced antitumor efficiency observed vivo. This provides new synergistic strategy ‐overload‐based therapy, offering broad application prospects treatment cancer.

Язык: Английский

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications DOI
Joana Lopes, Daniela Lopes, Miguel Pereira‐Silva

и другие.

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

Процитировано

148
Biomimetic cell membrane‐coated poly(lactic‐ co ‐glycolic acid) nanoparticles for biomedical applications DOI Creative Commons
Nasrullah Jan, Asadullah Madni, Safiullah Khan

и другие.

Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)

Опубликована: Ноя. 2, 2022

Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.

Язык: Английский

Процитировано

87
Immuno‐Engineered Nanodecoys for the Multi‐Target Anti‐Inflammatory Treatment of Autoimmune Diseases DOI
Mengying Hou, Yuansong Wei, Ziyin Zhao

и другие.

Advanced Materials, Год журнала: 2022, Номер 34(12)

Опубликована: Янв. 19, 2022

Overactivated T cells and overproduced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response propel progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid) nanoparticles coated with programmed death-ligand 1 (PD-L1)-expressing macrophage membrane (PRM) are developed mediate multi-target interruption self-promoted cascade in AIDs. The PRM collected from IFN-γ-treated RAW 264.7 possesses elevated surface levels adhesion molecule receptors cytokine receptors, and, thus, systemically administered NDs afford higher accumulation level inflamed tissues stronger scavenging efficiency toward multiple cytokines. More importantly, IFN-γ treatment induces remarkable PD-L1 expression PRM, thereby allowing bind membrane-bound death-1 (PD-1) CD4+ cell surfaces or neutralize free soluble PD-1, which reconstructs PD-1/PD-L1 inhibitory axis suppress activation restore immune tolerance. As such, provoke potent cooperative anti-inflammatory immune-suppressive efficacies alleviate damages Zymosan A-induced arthritis mice dextran sulfate sodium-induced ulcerative colitis mice. This study provides an enlightened example for immuno-engineering cell-membrane-based NDs, rendering promising implications into AIDs via immune-modulation.

Язык: Английский

Процитировано

78
Magnetic Nanoparticles for Medical Applications: Updated Review DOI Creative Commons
Guadalupe G. Flores‐Rojas, Felipe López‐Saucedo, Ricardo Vera‐Graziano

и другие.

Macromol—A Journal of Macromolecular Research, Год журнала: 2022, Номер 2(3), С. 374 - 390

Опубликована: Авг. 2, 2022

Magnetic nanoparticles (MNPs) represent an advanced tool in the medical field because they can be modified according to biomedical approaches and guided by external magnetic human body. The first objective of this review is exemplify some promising applications field, including smart drug-delivery systems, therapies against cancer cells, radiotherapy, improvements diagnostics using resonance imaging (MRI), tissue engineering. Complementarily, second illustrate mechanisms action theoretical foundations related magnetoresponsive materials.

Язык: Английский

Процитировано

78
Cell membrane-coated nanomaterials for cancer therapy DOI Creative Commons
Shiying Zeng,

Qinglai Tang,

Minna Xiao

и другие.

Materials Today Bio, Год журнала: 2023, Номер 20, С. 100633 - 100633

Опубликована: Апрель 12, 2023

With the development of nanotechnology, nanoparticles have emerged as a delivery carrier for tumor drug therapy, which can improve therapeutic effect by increasing stability and solubility prolonging half-life drugs. However, are foreign substances humans, easily cleared immune system, less targeted to tumors, may even be toxic body. As natural biological material, cell membranes unique properties, such good biocompatibility, strong targeting ability, ability evade surveillance, high drug-carrying capacity. In this article, we review membrane-coated (CMNPs) their applications therapy. First, briefly describe CMNP characteristics applications. Second, present advantages different well nanoparticles, provide brief description process CMNPs, discuss current status application summarize shortcomings use in cancer propose future research directions. This summarizes progress on CMNPs therapy recent years assesses remaining problems, providing scholars with new ideas

Язык: Английский

Процитировано

58
Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives DOI Creative Commons

Xiaoding Shen,

Dayi Pan, Qiyong Gong

и другие.

Bioactive Materials, Год журнала: 2023, Номер 32, С. 445 - 472

Опубликована: Окт. 26, 2023

Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.

Язык: Английский

Процитировано

45
Revolutionizing Neurocare: Biomimetic Nanodelivery Via Cell Membranes DOI
Jun Liao, Lidong Gong,

Qingqiang Xu

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(26)

Опубликована: Апрель 7, 2024

Abstract Brain disorders represent a significant challenge in medical science due to the formidable blood–brain barrier (BBB), which severely limits penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into innovative realm biomimetic nanodelivery systems, including stem cell‐derived nanoghosts, tumor cell membrane‐coated nanoparticles, and erythrocyte membrane‐based carriers, highlighting their potential circumvent BBB's restrictions. By mimicking native properties, these nanocarriers emerge as promising solution for enhancing drug delivery brain, offering strategic advantage overcoming barrier's selective permeability. The unique benefits leveraging membranes from various sources is evaluated advanced technologies fabricating membrane‐encapsulated nanoparticles capable masquerading endogenous cells are examined. enables targeted broad spectrum therapeutic agents, ranging small molecule drugs proteins, thereby providing an approach neurocare. Further, contrasts capabilities limitations with traditional methods, underlining enable targeted, sustained, minimally invasive modalities. concluded perspective on clinical translation underscoring transformative impact landscape intractable brain diseases.

Язык: Английский

Процитировано

32
Anti-inflammatory mechanisms of neutrophil membrane-coated nanoparticles without drug loading DOI
Qing Zhang,

Chengyi Hu,

Jinwei Feng

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 12 - 24

Опубликована: Март 21, 2024

Язык: Английский

Процитировано

24
Macrophage based drug delivery: Key challenges and strategies DOI Creative Commons
Qian Guo, Zhong‐Ming Qian

Bioactive Materials, Год журнала: 2024, Номер 38, С. 55 - 72

Опубликована: Апрель 23, 2024

As a natural immune cell and antigen presenting cell, macrophages have been studied engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such excellent biocompatibility, long circulation, intrinsic inflammatory homing phagocytosis. Meanwhile, macrophages' uniquely high plasticity easy re-education polarization facilitates part efficacious therapeutics the treatment diseases or tumors. Although recent studies demonstrated promising advances in macrophage-based delivery, several challenges currently hinder further improvement therapeutic effect clinical application. This article focuses on main utilizing from selection macrophage sources, loading, maintenance phenotypes, migration release at target sites. In addition, corresponding strategies insights related these described. Finally, we also provide perspective shortcomings road translation production.

Язык: Английский

Процитировано

22
Biomimetic Exosomes: A New Generation of Drug Delivery System DOI Creative Commons
Xudong Wang, Xian Zhao,

Youxiu Zhong

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Май 23, 2022

Most of the naked drugs, including small molecules, inorganic agents, and biomacromolecule cannot be used directly for disease treatment because their poor stability undesirable pharmacokinetic behavior. Their shortcomings might seriously affect exertion therapeutic effects. Recently, a variety exogenous endogenous nanomaterials have been developed as carriers drug delivery. Among them, exosomes attracted great attention due to excellent biocompatibility, low immunogenicity, toxicity, ability overcome biological barriers. However, delivery significant challenges, such yields, complex contents, homogeneity, which limit application. Engineered or biomimetic fabricated through approaches tackle these drawbacks. We summarized recent advances in over past decades addressed opportunities challenges next-generation system.

Язык: Английский

Процитировано

45