Mitigation of ischemia/reperfusion injury via Selenium nanoparticles: suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation
Biomaterials,
Год журнала:
2025,
Номер
318, С. 123119 - 123119
Опубликована: Янв. 25, 2025
Язык: Английский
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 30, 2024
T
lymphocytes
that
infiltrate
the
tumor
microenvironment
(TME)
often
fail
to
function
as
effective
anti-cancer
agents.
Within
TME,
cell-to-cell
inhibitory
interactions
play
significant
roles
in
dampening
their
anti-tumor
activities.
Recent
studies
have
revealed
soluble
factors
released
TME
by
immune
and
non-immune
cells,
well
cells
themselves,
contribute
exacerbation
of
cell
exhaustion.
Our
understanding
cytokine
landscape
interrelationships,
impact
on
cancer
development
is
still
at
its
early
stages.
In
this
review,
we
aim
shed
light
Interleukin
(IL)
-6,
IL-9,
IL-10,
a
small
group
JAK/STAT
signaling-dependent
cytokines
harboring
cell-suppressive
effects
summarize
mechanisms
action.
Additionally,
will
explore
how
advancements
scientific
research
can
help
us
overcoming
obstacles
posed
suppress
tumors,
with
ultimate
objective
stimulating
further
investigations
for
novel
therapeutic
strategies
counteract
tumor-promoting
Язык: Английский
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer
Current Treatment Options in Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Язык: Английский
Recent advances and future perspectives in small molecule JAK2 inhibitors
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Май 20, 2025
The
Janus
kinase
(JAK)/Signal
Transducer
and
Activator
of
Transcription
(STAT)
signaling
pathway
is
essential
for
controlling
immune
function,
blood
cell
formation,
growth.
Dysregulation
this
implicated
in
various
diseases,
including
hematologic
malignancies,
autoimmune
disorders,
chronic
inflammatory
conditions.
This
review
provides
a
comprehensive
overview
the
structural
functional
aspects
JAK/STAT
signaling,
with
particular
focus
on
role
JAK2.
manuscript
explores
primary
regulators
pathway,
such
as
Suppressors
Of
Cytokine
Signaling
(SOCS),
Protein
Inhibitors
Activated
STATs
(PIAS),
Tyrosine
Phosphatases
(PTPs),
which
play
crucial
maintaining
cellular
balance
stability.
Additionally,
therapeutic
landscape
JAK2
inhibitors
explored,
covering
both
approved
investigational
drugs,
their
mechanisms
action,
efficacy,
safety
profiles.
Emerging
strategies
drug
repositioning
using
computational
approaches
experimental
validation
are
also
highlighted.
By
integrating
insights
from
molecular
docking
studies,
machine
learning
models,
assays,
emphasizes
potential
disease
management.
Язык: Английский
Inborn Errors of Immunity in Apoptosis
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(5)
Опубликована: Май 20, 2025
Inborn
errors
of
immunity
(IEIs)
are
a
group
more
than
485
disorders
that
impair
immune
development
and
function
with
variable
reported
incidence,
severity,
clinical
phenotypes.
A
subset
IEIs
blend
increased
susceptibility
to
infection,
autoimmunity,
malignancy
known
collectively
as
primary
regulatory
(PIRDs).
Programmed
cell
death,
or
apoptosis,
is
crucial
for
maintaining
the
balance
lymphocytes.
Genetic-level
identification
several
human
inherited
diseases
impaired
apoptosis
has
been
achieved,
such
autoimmune
lymphoproliferative
syndrome
(ALPS),
caspase-8
deficiency
state
(CEDS),
X-linked
(XLP),
Janus
kinase
(JAK)/signal
transducer
activator
transcription
(STAT)
pathway
disorders.
The
consequences
this
disease
manifested
by
abnormal
lymphocyte
accumulation,
resulting
in
features
lymphadenopathy,
hepatomegaly,
splenomegaly,
an
risk
lymphoma.
Additionally,
these
often
associated
disease,
particularly
involving
blood
cells.
Understanding
molecular
pathogenesis
conditions
provided
critical
insights
into
signaling
pathways
regulate
activation,
shedding
light
on
mechanisms
dysregulation.
This
review
focuses
intersection
between
lymphoproliferation,
discussing
how
dysregulation
contributes
These
characterized
excessive
and/or
immunodeficiency.
their
offered
new
activation.
Язык: Английский
Study on the Mechanism of Compound Zeqi Granule in Treating Psoriasis vulgaris Based on Network Pharmacology and Experimental Verification
Natural Product Communications,
Год журнала:
2024,
Номер
19(11)
Опубликована: Ноя. 1, 2024
Background
This
study
used
a
holistic
network
pharmacological
approach
to
clarify
the
mechanism
of
Compound
Zeqi
Granule
(CZG)
in
treating
psoriasis
vulgaris
(PV).
Methods
The
potential
bioactive
compounds
and
corresponding
targets
CZG
were
collected
searched
via
TCMSP
database.
Disease
PV
obtained
from
GeneCards
standardized
by
UniProt
GO
KEGG
enrichment
analyses
performed
using
Metascape
Then,
molecular
docking
verification
was
conducted
CB-Dock
Animal
experiments
validate
effects
on
PV.
Results
identified
99
compounds,
579
drug
targets,
822
PV-related
108
target
proteins.
biological
processes
primarily
related
regulation
defense
response,
inflammatory
responses,
cellular
response
lipid.
for
significantly
associated
with
20
pathways
including
JAK-STAT
signaling
pathway.
confirmed
that
exerted
its
therapeutic
promoting
expression
IL-10
JUN,
inhibiting
activation
STAT1
STAT3.
Conclusion
present
provides
evidence
supporting
efficacy
treatment
through
multi-compound,
multi-target
multi-pathway
lays
theoretical
foundation
further
experimental
research
this
field.
Язык: Английский