Study on the Mechanism of Compound Zeqi Granule in Treating Psoriasis vulgaris Based on Network Pharmacology and Experimental Verification DOI Creative Commons

Min Wu,

Tongtong Dong,

Ting Zhang

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(11)

Published: Nov. 1, 2024

Background This study used a holistic network pharmacological approach to clarify the mechanism of Compound Zeqi Granule (CZG) in treating psoriasis vulgaris (PV). Methods The potential bioactive compounds and corresponding targets CZG were collected searched via TCMSP database. Disease PV obtained from GeneCards standardized by UniProt GO KEGG enrichment analyses performed using Metascape Then, molecular docking verification was conducted CB-Dock Animal experiments validate effects on PV. Results identified 99 compounds, 579 drug targets, 822 PV-related 108 target proteins. biological processes primarily related regulation defense response, inflammatory responses, cellular response lipid. for significantly associated with 20 pathways including JAK-STAT signaling pathway. confirmed that exerted its therapeutic promoting expression IL-10 JUN, inhibiting activation STAT1 STAT3. Conclusion present provides evidence supporting efficacy treatment through multi-compound, multi-target multi-pathway lays theoretical foundation further experimental research this field.

Language: Английский

Mitigation of ischemia/reperfusion injury via Selenium nanoparticles: suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation DOI

Chunxia Chen,

Jingjing Ma, Sophia Xiaoxia Duan

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123119 - 123119

Published: Jan. 25, 2025

Language: Английский

Citations

4
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy DOI Creative Commons

Ludovica Lopresti,

Vanessa Tatangelo, Cosima T. Baldari

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studies have revealed soluble factors released TME by immune and non-immune cells, well cells themselves, contribute exacerbation of cell exhaustion. Our understanding cytokine landscape interrelationships, impact on cancer development is still at its early stages. In this review, we aim shed light Interleukin (IL) -6, IL-9, IL-10, a small group JAK/STAT signaling-dependent cytokines harboring cell-suppressive effects summarize mechanisms action. Additionally, will explore how advancements scientific research can help us overcoming obstacles posed suppress tumors, with ultimate objective stimulating further investigations for novel therapeutic strategies counteract tumor-promoting

Language: Английский

Citations

4
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer DOI
Xinyi Ding, Hao Huang, Fang Zhang

et al.

Current Treatment Options in Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Language: Английский

Citations

4
Recent advances and future perspectives in small molecule JAK2 inhibitors DOI
Muhammad Yasir, Jongseon Choe, Mubashir Hassan

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 20, 2025

The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling pathway is essential for controlling immune function, blood cell formation, growth. Dysregulation this implicated in various diseases, including hematologic malignancies, autoimmune disorders, chronic inflammatory conditions. This review provides a comprehensive overview the structural functional aspects JAK/STAT signaling, with particular focus on role JAK2. manuscript explores primary regulators pathway, such as Suppressors Of Cytokine Signaling (SOCS), Protein Inhibitors Activated STATs (PIAS), Tyrosine Phosphatases (PTPs), which play crucial maintaining cellular balance stability. Additionally, therapeutic landscape JAK2 inhibitors explored, covering both approved investigational drugs, their mechanisms action, efficacy, safety profiles. Emerging strategies drug repositioning using computational approaches experimental validation are also highlighted. By integrating insights from molecular docking studies, machine learning models, assays, emphasizes potential disease management.

Language: Английский

Citations

0
Inborn Errors of Immunity in Apoptosis DOI Creative Commons
Nadia Makkoukdji, Travis Satnarine, Alana Xavier de Almeida

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(5)

Published: May 20, 2025

Inborn errors of immunity (IEIs) are a group more than 485 disorders that impair immune development and function with variable reported incidence, severity, clinical phenotypes. A subset IEIs blend increased susceptibility to infection, autoimmunity, malignancy known collectively as primary regulatory (PIRDs). Programmed cell death, or apoptosis, is crucial for maintaining the balance lymphocytes. Genetic-level identification several human inherited diseases impaired apoptosis has been achieved, such autoimmune lymphoproliferative syndrome (ALPS), caspase-8 deficiency state (CEDS), X-linked (XLP), Janus kinase (JAK)/signal transducer activator transcription (STAT) pathway disorders. The consequences this disease manifested by abnormal lymphocyte accumulation, resulting in features lymphadenopathy, hepatomegaly, splenomegaly, an risk lymphoma. Additionally, these often associated disease, particularly involving blood cells. Understanding molecular pathogenesis conditions provided critical insights into signaling pathways regulate activation, shedding light on mechanisms dysregulation. This review focuses intersection between lymphoproliferation, discussing how dysregulation contributes These characterized excessive and/or immunodeficiency. their offered new activation.

Language: Английский

Citations

0
Study on the Mechanism of Compound Zeqi Granule in Treating Psoriasis vulgaris Based on Network Pharmacology and Experimental Verification DOI Creative Commons

Min Wu,

Tongtong Dong,

Ting Zhang

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(11)

Published: Nov. 1, 2024

Background This study used a holistic network pharmacological approach to clarify the mechanism of Compound Zeqi Granule (CZG) in treating psoriasis vulgaris (PV). Methods The potential bioactive compounds and corresponding targets CZG were collected searched via TCMSP database. Disease PV obtained from GeneCards standardized by UniProt GO KEGG enrichment analyses performed using Metascape Then, molecular docking verification was conducted CB-Dock Animal experiments validate effects on PV. Results identified 99 compounds, 579 drug targets, 822 PV-related 108 target proteins. biological processes primarily related regulation defense response, inflammatory responses, cellular response lipid. for significantly associated with 20 pathways including JAK-STAT signaling pathway. confirmed that exerted its therapeutic promoting expression IL-10 JUN, inhibiting activation STAT1 STAT3. Conclusion present provides evidence supporting efficacy treatment through multi-compound, multi-target multi-pathway lays theoretical foundation further experimental research this field.

Language: Английский

Citations

0