Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5951 - 5951
Опубликована: Май 29, 2024
Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children born to mothers with reduced immune responses stimuli which increase susceptibility infections. Recently, maternal western-style diets (WSDs), high fat simple sugars, been associated skewing neonatal cell development, recent evidence suggests that dysregulation innate immunity early life has long-term consequences metabolic diseases behavioral disorders later Several factors contribute abnormal tolerance or trained immunity, including changes gut microbiota, metabolites, epigenetic modifications. Critical knowledge gaps remain regarding mechanisms whereby these fetal postnatal especially precursor stem cells bone marrow liver. Components microbiota are transferred from consuming WSD their understudied identifying cause effect adaptive development needs be refined. Tools single-cell RNA-sequencing, analysis, spatial location specific liver for understanding system programming. Considering vital role function plays health, it will important understand how control developmental programming immunity.
Язык: Английский
Процитировано
10
Experimental & Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Abstract Host life is inextricably linked to commensal microbiota, which play a crucial role in maintaining homeostasis and immune activation. A diverse array of microbiota on the skin interacts with host, influencing physiology various ways. Early-life exposure has long-lasting effects, disruption epidermal barrier or transient these microorganisms can lead dysbiosis inflammation. Several have potential function as either commensals pathogens, both being influenced by pathogenesis inflammatory diseases. Here we explore impact host elucidate interactions between systems. deeper understanding may open new avenues for developing effective strategies address
Язык: Английский
Процитировано
0
The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(8)
Опубликована: Апрель 15, 2025
The immune system must distinguish pathogens from innocuous dietary antigens, but the precise mechanisms and cellular actors remain unclear. Here, we demonstrate that RORγt-lineage APCs are required for oral tolerance. Using lineage tracing single-cell sequencing, show these consist of three principal populations: type 3 innate lymphoid cells (ILC3s), dendritic cells, expressing Aire called RORγt eTACs (R-eTACs)-also known as Janus or Thetis cells. We R-eTACs, not ILC3s, tolerance induction. find R-eTACs probable myeloid origin uniquely express integrin β8 (Itgb8). Both MHCII Itgb8 expression in necessary to induce food-specific regulatory T Mice lacking with deletion fail generate Tregs instead develop a T-follicular helper response elevated antigen-specific antibodies. These findings establish critical mediators suggest novel targets modulate
Язык: Английский
Процитировано
0
Mucosal Immunology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider response. While ILC are relatively rare they found enriched within discrete microenvironments, predominantly barrier tissues. An emerging body of evidence implicates complex and multi-layered interactions between cell types, tissue structure external environment determinants function these niches. In this review we will discuss specific components that constitute ILC-associated microenvironments consider how act to determine health disease. The development holistic, integrated models environments inform new understanding contextual cues mechanisms protective versus disease-causing family.
Язык: Английский
Процитировано
0
Immunological Reviews, Год журнала: 2024, Номер 326(1), С. 17 - 34
Опубликована: Июль 13, 2024
Summary Oral tolerance promotes the suppression of immune responses to innocuous antigen and is primarily mediated by regulatory T cell (Tregs). The development oral begins in early life during a “window tolerance,” which occurs around weaning components breastmilk. Herein, we review factors dictating this window how Tregs are uniquely educated life. In life, translocation luminal for Treg induction dictated goblet cell‐associated passages (GAPs). GAPs colon negatively regulated maternally‐derived epidermal growth factor microbiota, restricting GAP formation “periweaning” period (postnatal day 11–21 mice, 4–6 months humans). solid food also diversification bacteria such that bacterially‐derived metabolites known promote Tregs—short‐chain fatty acids, tryptophan metabolites, bile acids—peak periweaning phase. Further, breastmilk immunoglobulins—IgA IgG—regulate both microbial diversity interaction microbes with epithelium, further controlling antigens presented cells. Overall, these elements work conjunction induce long‐lived population Tregs, weaning, crucial maintaining homeostasis adults.
Язык: Английский
Процитировано
2
Immunological Reviews, Год журнала: 2024, Номер 323(1), С. 5 - 7
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
1
Advances in Clinical Medicine, Год журнала: 2024, Номер 14(05), С. 2457 - 2470
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0