Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy

JAMA Network Open, Год журнала: 2023, Номер 6(4), С. e237396 - e237396

Опубликована: Апрель 10, 2023

Importance Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association infection parent-reported infant outcomes, but standardized observational assessments are needed to confirm this finding. Objective To assess whether mild or asymptomatic maternal vs during pregnancy is associated with differences at ages 5 11 months. Design, Setting, Participants This cohort included infants of mothers from a single-site prospective cross-sectional (COVID-19 Mother Baby Outcomes [COMBO] Initiative) mother-infant dyads multisite (Epidemiology Severe Acute Respiratory Syndrome Coronavirus 2 in Pregnancy Infancy [ESPI]) pregnant individuals. subset ESPI participants was subsequently enrolled the COMBO substudy. ongoing were beginning on May 26, 2020; 7 November 3, 2021; substudy August 2020 March 2021. For current analysis, neurodevelopment assessed 2021 June 2022. total 407 born 403 (204 Columbia University Irving Medical Center New York, York; 167 Utah Salt Lake City; 36 Alabama Birmingham). Mothers unexposed approached for participation based similar gestational age birth, date sex, mode delivery exposed infants. Exposures Maternal symptomatic infection. Main Measures Infant using Developmental Assessment Young Children, second edition (DAYC-2), adapted telehealth assessment. The primary outcome age-adjusted standard scores DAYC-2 subdomains: cognitive, gross motor, fine expressive language, receptive language. Results Among mothers, mean (SD) 32.1 (5.4) years; most White race (240 [59.6%]) non-Hispanic ethnicity (253 [62.8%]). infants, 367 (90.2%) full term 212 (52.1%) male. Overall, 258 (63.4%) had documented infection, 112 (27.5%) confirmed exposure, 37 (9.1%) before an indeterminate time. In adjusted models, not cognitive (β = 0.31; 95% CI, −2.97 3.58), motor 0.82; −1.34 2.99), 0.36; −0.74 1.47), language −1.00; −4.02 2.02), 0.45; −2.15 3.04) subdomain scores. Trimester symptom status Conclusions Relevance study, results novel telehealth-adapted assessment extended finding neurodevelopment. Given widespread continued high prevalence COVID-19, these data offer information that may be helpful individuals who experience infections.

Язык: Английский

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The effect of the COVID‐19 pandemic on infant development and maternal mental health in the first 2 years of life

Infancy, Год журнала: 2022, Номер 28(1), С. 107 - 135

Опубликована: Окт. 14, 2022

Abstract We investigated how exogenous variation in exposure to the COVID‐19 pandemic during first year of life is related infant development, maternal mental health, and perceived stress. Ninety‐three socioeconomically diverse pregnant women were recruited before participate a longitudinal study. Infants ranged age at beginning lockdown (0–9.5 months old), thus experiencing different durations across life. The duration was not associated with family demographic characteristics, suggesting it captured variability. tested associations between this child outcomes. also examined whether mother‐reported disruptive events correlated found no association socioemotional problems, language or health stress symptoms, 12 24 months. However, we that self‐reported pandemic‐related predicted greater depression, anxiety, months, depression anxiety Socioeconomic status did moderate these associations. These findings suggest cautious optimism for infants raised period.

Язык: Английский

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Language acquisition in a post-pandemic context: the impact of measures against COVID-19 on early language development

Frontiers in Psychology, Год журнала: 2023, Номер 14

Опубликована: Июль 27, 2023

Language acquisition is influenced by the quality and quantity of input that language learners receive. In particular, early development has been said to rely on acoustic speech stream, as well language-related visual information, such cues provided mouth interlocutors. Furthermore, children's expressive skills are also variability interlocutors input. The COVID-19 pandemic offered an unprecedented opportunity explore way these factors affect development. On one hand, pervasive use masks diminishes speech, while it reduces language. other lockdowns restrictions regarding social gatherings have considerably limited amount interlocutor in present study aims at analyzing effects measures against To this end, 41 children born 2019 2020 were compared with before 2012 using Catalan adaptation MacArthur-Bates Communicative Development Inventories (MB-CDIs). Results do not show significant differences vocabulary between pre- post-Covid children, although there a tendency for lower levels be group. relationship was found participants' vocabulary, indicating those participants fewer opportunities socio-communicative diversity showed scores. These results reinforce recent findings their impact learning.

Язык: Английский

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The effects of Covid-19 related policies on neurocognitive face processing in the first four years of life

Developmental Cognitive Neuroscience, Год журнала: 2025, Номер 72, С. 101506 - 101506

Опубликована: Янв. 9, 2025

In response to Covid-19, western governments introduced policies that likely resulted in a reduced variety of facial input. This study investigated how this affected neural representations face processing: speed processing; categorization (differentiating faces from houses); and emotional processing happy, fearful, neutral expressions), infants (five or ten months old) children (three years old). We compared participants tested before (total N = 462) versus during 473) the pandemic-related policies, used electroencephalography record brain activity. Event Related Potentials showed faster three-year-olds but not policies. However, there were no meaningful differences between two Covid-groups regarding categorization, indicating fundamental process is resilient despite contrast, emotions was affected: across ages, while pre-pandemic differential activity, during-pandemic did neurocognitively differentiate happy fearful expressions. effect primarily attributed amplitude faces. Given these findings present only later components (P400 Nc), suggests post-pandemic have familiarity attention towards

Язык: Английский

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Impact of Pandemic-Related Social Restrictions on Language and Speech Development in Children with Cleft Lip and/or Palate at 18-24 Months

The Cleft Palate-Craniofacial Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Objective Determine if early speech and language development in children born with cleft lip and/or palate (CL/P) was impacted by social restrictions during the COVID-19 pandemic. Design Cohort study using data from The Cleft Collective. Participants Children CL/P whose first 18-24 months were before pandemic compared to Measures Primary outcome: parental reported Ages Stages Questionnaire—Third Edition (ASQ-3). Secondary outcomes: 18- 24-month therapy (SLT) assessment location; ability judge velopharyngeal function for speech; SLT judged-expressive consonant inventory size a palate. Analyses adjusted confounders. Results We found no statistical evidence suggest difference ASQ-3 communication (n = 631; OR 0.96; 95% CIs 0.533, 1.742; P 0.902), judgements of expressive 175; 0.66; 0.224, 1.947; 0.452), or at age 186; IRR 0.98; 0.775, 1.249; 0.896) between pre-pandemic groups. There weak an association virtual appointments being unable rate features (OR 3.54; 95%CIs 0.849, 14.755; 0.083). Conclusions No exposure pandemic-related months. Small sample sizes, variation groups, limitations measures should be considered when interpreting findings. Further work is required further examine use assessment.

Язык: Английский

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Effects of the COVID-19 Pandemic on Early Child Development: A Systematic Review & Meta-Analysis

Journal of Developmental & Behavioral Pediatrics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

ABSTRACT Objective: To explore the effects of COVID-19 pandemic on early childhood development and identify areas interest surrounding development. Methods: A systematic literature review was performed to articles examining how has affected development, a meta-analysis conducted from results those examine degree impact Results: Ten 6 countries were identified that met all inclusion exclusion criteria. The multivariate showed no significant difference in overall (pooled Cohen's d = 0.28, 95% CI, −0.33 0.88; p 0.18) or odds for developmental delay ratio (OR) 1.44, 0.77 2.67; 0.20) between pre-COVID-19 However, there significantly more impairment ( 0.46, 0.003) greater (72%; OR 1.72, 0.01) language communication domain children versus children. Conclusion: While exposure not associated with global delays, it had child regarding communication. Further research monitoring is necessary, parents communities should focus increasing intervention enriched curriculum offset these delays.

Язык: Английский

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Maternal pandemic-related stress during pregnancy associates with infants’ socio-cognitive development at 12 months: A longitudinal multi-centric study

PLoS ONE, Год журнала: 2023, Номер 18(4), С. e0284578 - e0284578

Опубликована: Апрель 17, 2023

Background Prenatal maternal stress is a key risk factor for infants’ development. Previous research has highlighted consequences socio-emotional and cognitive outcomes, but less known what regards socio-cognitive In this study, we report on the effects of prenatal related to COVID-19 pandemic 12-month-old behavioral markers Methods Ninety infants their mothers provided complete longitudinal data from birth 12 months. At birth, reported pandemic-related during pregnancy. 12-month-age, remote mother-infant interaction was videotaped: after an initial 2-min face-to-face episode, experimenter remotely played series four auditory stimuli (2 human 2 non-human sounds). The sequence counterbalanced among participants each sound repeated three times every 10 seconds (Exposure, 30 seconds) while were instructed not interact with display neutral still-face expression. Infants’ orienting, communication, pointing toward source coded micro-analytically score (SCS) obtained by means principal component analysis. Results Infants equally oriented stimuli. All Exposure 80% exhibited any communication directed source, 48% showed at least one sound. Mothers who greater had higher probability showing no t = 2.14 ( p .035), or pointing, 1.93 .057). A significant negative linear association found between SCS months, R .07 .010), adjusting potential confounders. Conclusions This study suggests that might have increased altered development in as assessed through observational paradigm Special preventive attention should be devoted born pandemic.

Язык: Английский

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Maternal perceived stress and infant behavior during the COVID-19 pandemic

Pediatric Research, Год журнала: 2023, Номер 94(6), С. 2098 - 2104

Опубликована: Июль 27, 2023

Abstract Background Maternal stress has negative consequences on infant behavioral development, and COVID-19 presented uniquely stressful situations to mothers of infants born during the pandemic. We hypothesized that with higher levels perceived pandemic would report regulatory problems including crying interrupted sleep patterns. Methods As part 6 sites a longitudinal study, completed Perceived Stress Scale, Brief Infant Sleep Questionnaire, an Crying survey at ( n = 433) 12 344) months age. Results stress, which remained consistent age, was significantly positively correlated time taken settle infants. Although maternal not uninterrupted length, put correlated. also amount fussiness reported months. Conclusions Mothers who problems, specifically Examining how varying behaviors relate overall developmental status over is important next step. Impact Women giving birth Scale old, more disruptive patterns in their old. Sleeping excessive infancy are two known risk factors for emotional issues later childhood. This paper one first studies highlighting associations between

Язык: Английский

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Prenatal family income, but not parental education, is associated with resting brain activity in 1-month-old infants

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 13, 2024

Abstract Childhood socioeconomic disadvantage is associated with disparities in development and health, possibly through adaptations children’s brain function. However, it not clear how early such neural might emerge. This study examined whether prenatal family status, operationalized as income average years of parental education, prospectively predicts individual differences infant resting electroencephalography (EEG; theta, alpha, beta, gamma power) at approximately 1 month age (N = 160). Infants mothers reporting lower showed more lower-frequency (theta) less higher-frequency (beta gamma) power. These associations held when adjusting for other postnatal experiences, well demographic health-related factors. In contrast, education was significantly EEG power any frequency band. data suggest that developmental function are detectable within the first life.

Язык: Английский

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Prolonged COVID-19 related effects on early language development: A longitudinal study

Early Human Development, Год журнала: 2024, Номер 195, С. 106081 - 106081

Опубликована: Июль 17, 2024

There is growing evidence that COVID-19 brought changes immediately affected early language development. Little known for how long these related shaped The current study systematically and longitudinally addressed this issue, following up children's development throughout the first 2.5 years. present follows on sample from Frota et al. (2022), which demonstrated 7–9-month-old infants born raised during pandemic do not segment words unlike pre-pandemic peers. Four studies were conducted: (1) word segmentation task at 12 months of age (Npandemic = 15); (2) learning 20 20); (3) communication to 30 age, via CDI CSBS parental reports ranged 25–74); (4) overall using Griffiths Developmental Scales 16). consistently underperformed in all four comparison data. was no developed abilities successful age. Lexical between 24 lower than sample, while social did seem be affected. At showed scores mental Language Communication Griffiths' subscale, Infants have a poorer development, persists least until

Язык: Английский

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