Evaluation of the antioxidant activity of melatonin in vitro

Free Radical Biology and Medicine, Год журнала: 1996, Номер 21(3), С. 307 - 315

Опубликована: Янв. 1, 1996

Язык: Английский

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Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis*

Critical Care Medicine, Год журнала: 2002, Номер 30(3), С. 536 - 540

Опубликована: Март 1, 2002

SCCM Pediatric Critical Care Medicine Explorations

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Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation

FEBS Letters, Год журнала: 1997, Номер 408(3), С. 297 - 300

Опубликована: Май 26, 1997

We tested the effect of melatonin on membrane fluidity in microsomes a rat liver model which lipid peroxidation was induced by addition FeCl 3 , ADP and NADPH. Membrane monitored using fluorescence spectroscopy estimated quantifying malonaldehyde (MDA)+4‐hydroxyalkenals (4‐HDA) concentrations following induction with without pre‐incubation (1 μ M–3 mM). rigidity increased during while reduced concentration‐dependent manner both MDA+4‐HDA generation. Melatonin's protective may relate to its known ability scavenge free radicals function as an antioxidant.

Язык: Английский

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Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation

Proceedings of The Society for Experimental Biology and Medicine, Год журнала: 2000, Номер 225(1), С. 9 - 22

Опубликована: Окт. 1, 2000

Abstract. Ionizing radiation is classified as a potent carcinogen, and its injury to living cells is, large extent, due oxidative stress. The molecule most often reported be damaged by ionizing DNA. Hydroxyl radicals ( • OH), considered the damaging of all free generated in organisms, are responsible for DNA damage caused radiation. Melatonin, N‐acetyl‐5‐methoxytryptamine, well‐known antioxidant that protects DNA, lipids, proteins from free‐radical damage. indoleamine manifests antioxidative properties stimulating activities enzymes scavenging directly or indirectly. Among known antioxidants, melatonin highly effective scavenger OH. Melatonin distributed ubiquitously organisms and, far known, cellular compartments, it quickly passes through biological membranes. protective effects against stress have been documented vitro vivo studies different species experiments used human tissues, well when was given humans then tissues collected subjected radioprotective low toxicity make this potential supplement treatment co‐treatment situations where minimized.

Язык: Английский

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Melatonin as a radioprotective agent: a review

International Journal of Radiation Oncology*Biology*Physics, Год журнала: 2004, Номер 59(3), С. 639 - 653

Опубликована: Июнь 9, 2004

Язык: Английский

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