Melatonin: Buffering the Immune System

International Journal of Molecular Sciences, Год журнала: 2013, Номер 14(4), С. 8638 - 8683

Опубликована: Апрель 22, 2013

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite large number reports implicating melatonin as an immunomodulatory compound, it still remains unclear how regulates immunity. While some authors argue that is immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support idea buffer, acting stimulant under basal or immunosuppressive conditions compound presence exacerbated responses, such acute inflammation. clinical relevance multiple different conditions, infection, autoimmunity, vaccination and immunosenescence, reviewed.

Язык: Английский

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A Review of the Multiple Actions of Melatonin on the Immune System

Endocrine, Год журнала: 2005, Номер 27(2), С. 189 - 200

Опубликована: Янв. 1, 2005

Язык: Английский

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Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways

American Journal of Geriatric Psychiatry, Год журнала: 2013, Номер 21(12), С. 1190 - 1222

Опубликована: Ноя. 8, 2013

Язык: Английский

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Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

The Journal of Immunology, Год журнала: 2010, Номер 185(10), С. 5796 - 5805

Опубликована: Окт. 14, 2010

Circadian rhythms modulate nearly every mammalian physiological process. Chronic disruption of circadian timing in shift work or during chronic jet lag animal models leads to a higher risk several pathologies. Many these conditions both workers and experimental share the common factor inflammation. In this study, we show that experimentally induced altered innate immune responses. Endotoxemic shock by LPS was magnified, leading hypothermia death after four consecutive weekly 6-h phase advances light/dark schedule, with 89% mortality compared 21% unshifted control mice. This may be due heightened release proinflammatory cytokines response treatment shifted animals. Isolated peritoneal macrophages harvested from mice exhibited similarly vitro, indicating cells are target for lag. Sleep deprivation stress known alter function potential mediators effects describe. However, polysomnographic recording exposed shifting schedule revealed no sleep loss, measures were not contrast, observed abolished expression clock genes central clock, liver, thymus, We conclude disruption, but loss stress, associated lag-related dysregulation system. Such changes might mechanism myriad negative health work.

Язык: Английский

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Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure

International Journal of Geriatric Psychiatry, Год журнала: 2017, Номер 33(11), С. 1428 - 1457

Опубликована: Дек. 26, 2017

Delirium is the most common neuropsychiatric syndrome encountered by clinicians dealing with older adults and medically ill best characterized 5 core domains: cognitive deficits, attentional circadian rhythm dysregulation, emotional alteration in psychomotor functioning.An extensive literature review consolidation of published data into a novel interpretation known pathophysiological causes delirium.Available suggest that numerous pathological factors may serve as precipitants for delirium, each having differential effects depending on patient-specific patient physiological characteristics (substrate). On basis an search, newly proposed theory, systems integration failure hypothesis, was developed to bring together salient previously described theories, describing various contributions from complex web pathways-highlighting areas intersection commonalities explaining how variable contribution these lead development behavioral dysfunctions characteristic delirium. The specific manifestations delirium picture result combination neurotransmitter function availability, variability processing sensory information, motor responses both external internal cues, degree breakdown neuronal network connectivity, hence term acute brain failure.The hypothesis attempts explain pathophysiologic theories interact other, causing clinically observed phenotypes. A better understanding underlying pathophysiology eventually assist designing prevention management approaches.

Язык: Английский

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Sleep Deprivation in Critical Illness

Journal of Intensive Care Medicine, Год журнала: 2011, Номер 27(2), С. 97 - 111

Опубликована: Янв. 10, 2011

Critically ill patients frequently experience poor sleep, characterized by frequent disruptions, loss of circadian rhythms, and a paucity time spent in restorative sleep stages. Factors that are associated with disruption the intensive care unit (ICU) include patient-ventilator dysynchrony, medications, patient interactions, environmental noise light. As field critical increasingly focuses on patients’ physical psychological outcomes following illness, understanding potential contribution ICU-related recovery is an important area investigation. This review article summarizes literature regarding architecture measurement critically ill, causes ICU fragmentation, implications from illness. With this background information, strategies to optimize also discussed.

Язык: Английский

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Melatonin receptors in humans: biological role and clinical relevance

Biomedicine & Pharmacotherapy, Год журнала: 2006, Номер 60(3), С. 97 - 108

Опубликована: Фев. 21, 2006

Язык: Английский

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Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations

Mitochondrion, Год журнала: 2021, Номер 59, С. 225 - 245

Опубликована: Апрель 9, 2021

Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and predictor mortality, but little known about cf-mtDNA in relation to psychobiology. A systematic review the literature reveals that blood varies response common real-world stressors including psychopathology, acute psychological stress, exercise. Moreover, inducible within minutes exhibits high intra-individual day-to-day variation, highlighting dynamic regulation levels. We discuss current knowledge on mechanisms release, its forms transport ("cell-free" does not mean "membrane-free"), potential physiological functions, putative cellular neuroendocrine triggers, factors may contribute removal from circulation. vitro, pre-clinical, clinical studies shows conflicting results around dogma are pro-inflammatory, opening possibility other cell-to-cell transfer whole mitochondria. Finally, enhance reproducibility biological interpretation human research, we propose guidelines for collection, isolation, quantification, reporting standards, which can promote concerted advances by community. Defining mechanistic basis signaling an opportunity elucidate role mitochondria brain-body interactions psychopathology.

Язык: Английский

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Sleep in the intensive care unit

Intensive Care Medicine, Год журнала: 2004, Номер 30(2), С. 197 - 206

Опубликована: Фев. 1, 2004

Язык: Английский

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Sleep and delirium in ICU patients: a review of mechanisms and manifestations

Intensive Care Medicine, Год журнала: 2009, Номер 35(5), С. 781 - 795

Опубликована: Янв. 22, 2009

Язык: Английский

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