Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe)

Journal Of Clinical Periodontology, Год журнала: 2023, Номер 50(6), С. 819 - 841

Опубликована: Март 20, 2023

Abstract Aim To explore the implications for dentists and family doctors of association between periodontal systemic diseases role in managing non‐communicable (NCDs) promoting healthy lifestyles. Materials Methods The consensus reports previous Focused Workshops on associations periodontitis diabetes (2017) cardiovascular (2019) formed technical reviews to underpin discussions both topics. For with respiratory diseases, a systematic review was specifically commissioned Workshop discussions. Working groups prepared proposals independently, then were discussed approved at plenary meetings. Results Periodontitis is independently associated diabetes, chronic obstructive pulmonary disease (COPD), sleep apnea COVID‐19 complications. Dentists should collaborate NCDs, implementing strategies early detection primary care centres or dental settings. Family be informed about their consequences, oral health professionals (OHPs) relevance NCDs risk factors. Conclusions Closer collaboration OHPs important management Pathways case medicine practices developed evaluated.

Язык: Английский

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Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited

Frontiers in Cardiovascular Medicine, Год журнала: 2021, Номер 7

Опубликована: Янв. 15, 2021

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory of the coronary arteries associated with atheroma formation, which can cause disability and often death. Periodontitis ranked as sixth most prevalent affecting humans 740 million people worldwide. In last few decades, researchers have focused on effect periodontal (PD) disease. The aim this review was to investigate association between these two diseases. PD a potential risk factor that may initiate development, maturation, instability in arteries. Two mechanisms were proposed explain such association, either pathogens directly invade bloodstream or indirectly by increasing systemic level mediators. Interestingly, it has been suggested improvement condition one positively impact other one. Highlighting diseases, importance early diagnosis treatment its status be great value reducing complications ACVDs. Further vitro vivo studies longer follow up are necessary confirm causal relationship

Язык: Английский

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Nutrition as a Key Modifiable Factor for Periodontitis and Main Chronic Diseases

Journal of Clinical Medicine, Год журнала: 2021, Номер 10(2), С. 197 - 197

Опубликована: Янв. 7, 2021

Nutrition is recognized as an essential component in the prevention of a number chronic diseases, including periodontal disease. Based on these considerations, better understanding required regarding how diet, and more particularly intake macronutrients micronutrients, could impact potential relationship between nutrition diseases diseases. To overcome this complexity, up-to-date literature review nutriments related to was performed. High-sugar, high-saturated fat, low-polyols, low-fiber low-polyunsaturated-fat causes increased risk This pattern nutrients classically found Western which considered ‘unhealthy’ diet that cardiovascular diabetes cancers. Conversely, low-sugar, high-fiber high-omega-6-to-omega-3 fatty acid ratio reduces The Mediterranean, DASH, vegetarian Okinawa diets correspond nutritional intakes are ‘healthy’ diets, reducing role such vitamin D, E, K magnesium, remains unclear, while others, A, B, C, calcium, zinc polyphenols have been shown prevent PDs. Some evidence suggests probiotics prebiotics promote health. Periodontal share, with time delay, factor. Thus, any change health should be warning signal control dietary quality patients thus reduce developing later on.

Язык: Английский

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Improving the Accuracy for Analyzing Heart Diseases Prediction Based on the Ensemble Method

Complexity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Heart disease is the deadliest and one of leading causes death worldwide. Machine learning playing an essential role in medical side. In this paper, ensemble methods are used to enhance performance predicting heart disease. Two features extraction methods: linear discriminant analysis (LDA) principal component (PCA), select from dataset. The comparison between machine algorithms applied selected features. different evaluate models: accuracy, recall, precision, F‐measure, ROC.The results show bagging method with decision tree has achieved best performance.

Язык: Английский

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The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 10, 2022

Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although treatment periodontitis has improved recently, effective periodontitis-affected still a challenge. Therefore, it urgent explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant bone protective effects most these natural are safe cost-effective. Among these, plant-derived exosome-like nanoparticles (PELNs), type nanocarriers repleted with lipids, proteins, RNAs, other active molecules, ability enter mammalian cells regulate cellular activities. Reports from literature indicate great potential PELNs in regulation immune functions, inflammation, microbiome, tissue regeneration. Moreover, can also be used as drug carriers enhance stability uptake vivo. Since function, regeneration key phenomena usually targeted during treatment, hold promising treatment. This review summarizes recent advances PELNs-related research that related periodontitis-destructed underlying mechanisms. We discuss existing challenges prospects application PELNs-based approaches

Язык: Английский

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The oral microbiome in the pathophysiology of cardiovascular disease

Nature Reviews Cardiology, Год журнала: 2023, Номер 20(6), С. 386 - 403

Опубликована: Янв. 9, 2023

Язык: Английский

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The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders

Frontiers in Psychiatry, Год журнала: 2022, Номер 12

Опубликована: Янв. 27, 2022

The prevalence of anxiety, mood and trauma- stress-related disorders are on the rise; however, efforts to develop new effective treatment strategies have had limited success. To identify novel therapeutic targets, a comprehensive understanding disease etiology is needed, especially in context holobiont, i.e., superorganism consisting human its microbiotas. Much emphasis has been placed role gut microbiota development, exacerbation, persistence psychiatric disorders; data for oral limited. cavity houses second most diverse microbial community body, with over 700 bacterial species that colonize soft hard tissues. Periodontal diseases encompass group infectious inflammatory affect periodontium. Among them, periodontitis defined as chronic, multi-bacterial infection elicits low-grade systemic inflammation via release pro-inflammatory cytokines, well local invasion long-distance translocation periodontal pathogens. Periodontitis can also induce or exacerbate other chronic such atherosclerosis diabetes lead adverse pregnancy outcomes. Recently, pathogens implicated pathophysiology neuropsychiatric (such depression schizophrenia), dysregulation immune system plays an integral these disorders. This review will discuss associated Epidemiological individuals be presented, followed by discussion microbiological immunological links between central nervous system. Pre-clinical clinical findings related phenotypes reviewed, bi-directionality oral-brain axis. Lastly, we focus target future interventions alleviate symptoms debilitating

Язык: Английский

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The association between oxidative balance score and periodontitis in adults: a population-based study

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Апрель 28, 2023

Introduction The pathogenesis between oxidative stress and periodontitis was correlated. Oxidative Balance Score (OBS) is a systematic tool to assess the effects of diet lifestyle in relation stress. However, association OBS has not been reported previously. Methods Sixteen dietary factors four were selected score OBS. Multivariate logistic regression sensitivity analysis used investigate relationship based on data from National Health Nutrition Examination Survey (NHANES) 1999–2018. Subgroup interaction tests whether this stable across populations. Results This study included 3,706 participants. There negative linear all participants [0.89 (0.80, 0.97)], after converting quartile variable, with highest had 29% lower risk than those lowest [0.71 (0.42, 0.98)]. differed respect age diabetes. Conclusion US adults. Our results suggest that may be as biomarker for measuring periodontitis.

Язык: Английский

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The oral–gut microbiome axis in health and disease

Nature Reviews Microbiology, Год журнала: 2024, Номер 22(12), С. 791 - 805

Опубликована: Июль 22, 2024

Язык: Английский

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Periodontal diseases and cardiovascular diseases, diabetes, and respiratory diseases: Summary of the consensus report by the European Federation of Periodontology and WONCA Europe

European Journal of General Practice, Год журнала: 2024, Номер 30(1)

Опубликована: Март 21, 2024

Periodontitis is a chronic inflammatory non-communicable disease (NCD) characterised by the destruction of tooth-supporting apparatus (periodontium), including alveolar bone, presence periodontal pockets, and bleeding on probing.

Язык: Английский

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