Causal effects of gut microbiota on the risk of periodontitis: a two-sample Mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 25, 2023

Introduction The oral cavity and the gut tract are interconnected, both contain abundant natural microbiota. Gut microbiota may interact with flora participate in development of periodontitis. However, specific role certain taxa for periodontitis has not been investigated. Mendelian Randomization is an ideal method to explore causal relationships avoiding reverse causality potential confounding factors. Thus, we conducted a two-sample study comprehensively reveal genetic effect on Methods SNPs strongly associated 196 (18,340 individuals) were selected as instrument variables, (17,353 cases 28,210 controls) was used outcome. analyzed via random inverse variance-weighted, weighted median, MR-Egger. sensitivity analyses using Cochran’s Q tests, funnel plots, leave-one-out analyses, MR-Egger intercept tests. Results Nine ( Prevotella 7, Lachnospiraceae UCG-008, Enterobacteriales , Pasteurellales Enterobacteriaceae Pasteurellaceae Bacteroidales S24.7 group, Alistipes Eisenbergiella ) predicted play enhancing risk p < 0.05). Besides, two Butyricicoccus Ruminiclostridium 6) have potentially inhibitive effects No significant estimation heterogeneity or pleiotropy detected. Conclusion Our demonstrates provides guidance clinical intervention

Язык: Английский

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Associations between vitamin D levels and periodontal attachment loss

Clinical Oral Investigations, Год журнала: 2023, Номер 27(8), С. 4727 - 4733

Опубликована: Июнь 8, 2023

Язык: Английский

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Association of vitamin K, fibre intake and progression of periodontal attachment loss in American adults

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Май 17, 2023

Periodontitis-related attachment loss is accompanied by mucosal bleeding and inflammatory lesions. Dietary vitamin K fibre intake are known to be correlation factors of haemostasis anti-inflammation, respectively.To explore the association between severe periodontal or in American adults.A cross-sectional analysis was conducted including 2747 males 2218 females National Health Nutrition Examination Surveys (NHANES) from 2009 2014. The number teeth with (above 5 mm loss) used as dependent variable. main independent variables included dietary fibre. among examined using multivariable linear regression models, hierarchical regression, fitted smoothing curves, generalized additive models.Based on indicators 4965 subjects, we found that tended occur elderly individuals less fibre, well lower educational qualification. Vitamin stably negatively associated progression each model. In subgroup analyses, a negative identified all races except blacks (β = 0.0005, 95% CI: -0.0005 0.0016). relationship broad U-shaped curve (inflection point: 753.4 mg), which especially manifested 967.5 mg).There an inverse adults, while should moderate (below mg).

Язык: Английский

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Masticatory dysfunction in older adults: A scoping review

Journal of Oral Rehabilitation, Год журнала: 2023, Номер 50(8), С. 724 - 737

Опубликована: Май 15, 2023

Abstract Background Masticatory dysfunction impacts food selection, nutritional intake and social activities; all of which play a vital role to ensure good general health quality life. Despite the rapidly ageing population, there is limited evidence regarding risk factors that lead masticatory in older adults or protective may help maintain ability. Furthermore, currently no consensus for specific test measures Objectives The objectives this scoping review are identify associated with determine most commonly used objective measure performance. Design A was performed using PRISMA recommendations. MEDLINE (Ovid), Embase, Scopus Web Science databases were searched. Seventy‐eight articles included review. There six randomised controlled trials, interventional studies, one systematic review, quasi‐experimental study, five prospective cohort 58 cross‐sectional studies case–control study. Data analysed frequency reporting on factors, and/or Results This identified tooth loss as common factor dysfunction. Other notable musculoskeletal conditions such frailty sarcopenia, cognitive decline malnutrition. Additionally, presence addition teeth main factor. denture maintenance via liners adhesives, textured foods, oral exercises. Chewing gum function, followed by occlusal force sieve methods. Conclusions found causal link between each ability adults. Establishing standard method measuring performance chewing encouraging clinicians routinely function will enable comparisons across multiple improving base contributing better patient care.

Язык: Английский

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Food intake, masticatory function, tooth mobility, loss of posterior support, and diminished quality of life are associated with more advanced periodontitis stage diagnosis

Journal Of Clinical Periodontology, Год журнала: 2021, Номер 49(3), С. 240 - 250

Опубликована: Дек. 22, 2021

To describe periodontal and functional characteristics of subjects diagnosed with different stages periodontitis to associate measures masticatory function quality life stage.This was a cross-sectional study on convenience sample 214 seeking oral care in hospital setting. They received full-mouth intra-oral examination including dental charting by single calibrated examiner who also established the stage diagnosis. Subjects were assessed using OHIP-14, validated dysfunction questionnaire, quantitative test based ability mix dual colour chewing gum. Mixing quantified variance hue (VOH) colorimetric software. Descriptive, univariate, multivariate analyses performed.Subjects IV reported greater impairment oral-health-related life, reduced food intake or altered type attributed difficulties chewing, objective dysfunction, tooth loss, as well more advanced breakdown compared I-III disease. Quantitative assessment associated, analysis, (i) loss units premolar/molar region, presence hypermobile teeth, severity attachment (ii) age, body mass index, grade C diagnosis.Subjects are characterized specific set signs symptoms impairment, which impact function/food choices. Stage captures clinical entity distinct features treatment needs. This is registered ClinicalTrials.gov (NCT03928080).

Язык: Английский

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Association between masticatory performance and oral conditions in adults: A systematic review and meta-analysis

Journal of Dentistry, Год журнала: 2022, Номер 129, С. 104395 - 104395

Опубликована: Дек. 20, 2022

To give an overview of the evidence on associations between oral condition factors and masticatory performance adults, to evaluate direction level associations.Medline (PubMed), Embase (Ovid) CINAHL Plus (EBSCOhost) were searched up May 2022 for cross-sectional studies conditions in adults. Methodological quality included was independently evaluated based Joanna Briggs Institute critical appraisal checklist analytical studies. Data extracted. Meta-analysis conducted correlation coefficients.Of 8,035 records identified, 97 articles (88 studies) qualitative synthesis, 18 meta-analyses. Among that had with performance, number natural/remaining teeth or functional tooth pairs reported by largest studies, followed perioral muscle status, dental prosthetic moisture status periodontal status. Results meta-analyses showed positive association strongest (pooled coefficient: 0.51, 95%CI: 0.48 0.54), pairs, maximum tongue force/pressure, while weakest.Number are main influencing performance. Based limited available, among these factors, has association, a very low evidence.This study provides valuable information associated which would be important policymakers clinical practitioners when deciding strategies improving This review highlights need standardization measures classifications conditions.PROSPERO (registration number: CRD42021256824).

Язык: Английский

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Policies Supporting Oral Health in Ageing Populations Are Needed Worldwide

International Dental Journal, Год журнала: 2022, Номер 72(4), С. S27 - S38

Опубликована: Авг. 1, 2022

This literature review examines the need to develop appropriate policies specific oral health needs of older people that are individualised, cost-effective, and sustainable. Poor impaired function negatively affect quality life adults. Developing care systems aim meet patients' normative as well their perceived expectations is one factor in successful delivery dental care. Cost another significant driver utilisation, many adults worldwide lack adequate resources for Failure address these issues results poor outcomes increased costs medical Disease prevention control at early stages can preserve public private financial well-being any stage life.

Язык: Английский

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Masticatory performance in oral function assessment: Alternative methods

Journal of Oral Rehabilitation, Год журнала: 2023, Номер 50(5), С. 383 - 391

Опубликована: Янв. 24, 2023

Masticatory function declines with age or disease, implicating a poor chewing efficiency and an often-unconscious change for less healthy, yet easy to chew diet. Timely screening of masticatory may foster early-onset diagnosis potential treatment. The aim this study was compare alternative diagnostic tools Jelly-scan test.Patients aged 70 years older who were hospitalised rehabilitation recruited study. A total four different tests administered. Japanese Society Gerodontology glucose extraction test (Jelly-scan) used as reference colour-changing gum (Gum1-colour) well mixing ability visual (Gum2-visual) opto-electronical (Gum2-digital) analyses. Receiver operating characteristic (ROC) curves establish the discriminative value, kappa-values estimate individual agreements correlations verified using Spearman's tests.Sixty-one patients (Men n = 23, Women 38) 82.4 ± 6.8 participated in experiments. average number natural teeth 16.5 10.5, 34.4% participants wore removable dentures. For all tests, sum sensitivity specificity >150%. All correlated (absolute Rho >0.5). With 51 (83.6%) diagnosed "masticatory hypofunction". After reducing cut-off value from 100 mg/dL 65 mg/dL, only 33 (54%) fulfilled diagnosis. This post-hoc analysis increased Gum2-tests agreement kappa >0.5 three tests.All can be considered useful alternatives. In its original version, tend over-diagnose hypofunction, hence novel better between is suggested.

Язык: Английский

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Impact of Prosthetic Material and Restoration Type on Peri-Implant Bone Resorption: A Retrospective Analysis in a Romanian Sample

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(6), С. 1794 - 1794

Опубликована: Март 20, 2024

Background/Objectives: This research investigates the nuanced factors influencing peri-implant bone resorption in implant-supported fixed prostheses, with a focus on age, gender, implant location, time since prosthetic loading, and material characteristics. Methods: Records from dental clinic Oradea, Romania, between 1 January 2017 2023, were scrutinized selected by means of purposive sampling. All records analyzed May 2023 15 June 2023. A total 160 implants included, restorations either metal-ceramic or zirconia. Implants single manufacturer used, standardized loading protocol was followed. The study examined variables such as material, loading. Results: 78 applied to female patients (48.8%) 82 male (51.2%). age range undergoing procedures 30 79 years. distributed mandible (51.2%) maxilla (48.8%), 49.4% placed posterior arches 50.6% anterior arches. majority received reconstructions (76.9%). Statistical analysis revealed significant differences patterns zirconia (p < 0.001), exhibiting higher mesial-vertical distal-vertical planes compared restorations. Age-related showed association = 0.017), aged 60-69 years values those 40-49 Gender observed mesial-horizontal 0.036), displaying patients. Implant location elapsed did not show associations patterns. Conclusions: provides insights into multifactorial nature resorption. Age, characteristics contribute variations, informing personalized treatment approaches. findings facilitate comprehensive understanding for clinicians, enhancing planning post-operative care.

Язык: Английский

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Influence of mobility on the long‐term risk of tooth extraction/loss in periodontitis patients. A systematic review and meta‐analysis

Journal of Periodontal Research, Год журнала: 2024, Номер unknown

Опубликована: Май 20, 2024

Abstract The aim of this systematic review (SR) was to assess whether tooth mobility (TM) increases the risk extraction/loss. protocol registered in PROSPERO database (CRD42023485425). focused PECO questions were as follows: (1) “In patients with periodontitis, undergoing periodontal treatment, are teeth affected by at higher being extracted/lost compared non‐mobile teeth, a minimum follow‐up 10 years?” and (2) these patients, does varying degrees increase extraction/loss, years?”. Results reported according PRISMA statement. Electronic manual searches conducted identify longitudinal studies. different assessments pooled into three groups: TM0: Undetectable mobility, TM1: Horizontal/Mesio‐distal ≤1 mm, TM2: >1 mm or vertical mobility. Tooth loss primary outcome. Various meta‐analyses conducted, including subgroup analyses considering lengths timing TM assessment, along sensitivity analyses. A trial sequential analysis also performed. Eleven studies included (1883 patients). mean range 10–25 years. weighted total based on sample size, 18 918, 1604 (8.47%) teeth. overall rate extraction/loss increased increasing mobility: TM0 associated 5.85% (866/14822), TM1 11.8% (384/3255), TM2 40.3% (339/841). Mobile (TM1/TM2) an for (HR: 2.85; [95% CI 1.88–4.32]; p < .00001). had than 1.96; 1.09–3.53]; 2.19–3.70]; .00001) 7.12; 3.27–15.51]; results tests differences not significant. Sensitivity yielded consistent other meta‐analyses. Within limits quality meta‐analyses, mobile long‐term significantly influenced clinicians‘ decision extract tooth. However, most can be retained thus should considered reason extraction factor loss, regardless degree TM.

Язык: Английский

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