Axioms,
Год журнала:
2024,
Номер
13(7), С. 417 - 417
Опубликована: Июнь 21, 2024
Inequalities
involving
fractional
operators
have
been
an
active
area
of
research,
which
is
crucial
in
establishing
bounds,
estimates,
and
stability
conditions
for
solutions
to
integrals.
In
this
paper,
we
initially
presented
a
new
class
that
known
as
coordinated
left
right
ℏ-pre-invex
interval-valued
mappings
(C·L·R-ℏ-pre-invex
Ι·V-M),
well
classical
convex
nonconvex
are
also
obtained.
This
newly
defined
enabled
us
derive
novel
inequalities,
such
Hermite–Hadamard
Pachpatte’s
type
inequalities.
Furthermore,
the
obtained
results
allowed
recapture
several
special
cases
different
parameter
choices,
can
be
applications
main
results.
Finally,
discussed
validity
outcomes.
European journal of medical research,
Год журнала:
2023,
Номер
28(1)
Опубликована: Авг. 17, 2023
To
explore
the
forewarning
immunological
indicators
during
periodontal
attachment
loss
progression
in
American
adults.A
total
of
5744
participants
with
were
enrolled
from
National
Health
and
Nutrition
Examination
Surveys
(NHANES)
2009-2014.
In
which,
dependent
variable
was
counts
teeth
severe
(depth
probing
above
5
mm).
Independent
variables
circulatory
indexes,
including
white
blood
cells
(WBC),
Lymphocytes,
Monocytes,
Neutrophils,
Eosinophils,
Basophils.
The
association
among
examined
using
multivariable
linear
regression
models,
fitting
smoothing
curves,
generalizing
additive
models.Based
on
subjects,
we
found
that
tended
to
occur
elderly
or
males
accompanied
by
higher
WBC,
as
well
lower
poverty-income
ratio
educational
qualification.
WBC
(above
inflection
point:
6200
cells/µL)
Neutrophils
3300
positively
associated
each
model.
On
subgroup
analyses,
stratified
sex
race,
positive
correlation
stable
both
men
women,
all
races
except
blacks
(WBC
β
=
-
0.0576,
95%
CI
0.1945
0.0793,
0.0527,
0.2285
0.1231).Increasing
risk
races,
blacks.
Biomedical Physics & Engineering Express,
Год журнала:
2024,
Номер
10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract
Purpose
.
This
review
aims
to
highlight
current
improvements
in
microfluidic
devices
designed
for
digestive
cancer
simulation.
The
emphasizes
the
use
of
multicellular
3D
tissue
engineering
models
understand
complicated
biology
tumor
microenvironment
(TME)
and
progression.
purpose
is
develop
oncology
research
improve
patients’
lives.
Methods
analyzes
recent
on
mimicking
cancer.
It
uses
tissue-engineered
devices,
notably
organs
a
chip
(OOC),
simulate
human
organ
function
lab.
Cell
cultivation
modern
three-dimensional
hydrogel
platforms
allows
precise
geometry,
biological
components,
physiological
qualities.
novel
methodologies,
key
findings,
technical
progress
explain
this
field’s
advances.
Results
study
discusses
advances
Micro
systems
with
are
emphasized.
These
capture
complex
biochemical
gradients,
niche
variables,
dynamic
cell–cell
interactions
(TME).
reveal
stomach
progression
by
duplicating
TME.
Recent
discoveries
technology
have
improved
our
understanding
gut
biology,
as
shown
review.
Conclusion
Microfluidic
play
crucial
role
modeling
furthering
research.
could
transform
drug
development
treatment
revealing
provides
complete
summary
suggests
future
field
professionals.
review’s
major
goal
further
medical
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(10)
Опубликована: Окт. 1, 2024
ABSTRACT
Nanogels
represent
a
significant
innovation
in
the
fields
of
nanotechnology
and
biomedical
engineering,
combining
properties
hydrogels
nanoparticles
to
create
versatile
platforms
for
drug
delivery,
tissue
bioimaging,
other
applications.
These
nanoscale
hydrogels,
typically
ranging
from
10
1000
nm,
possess
unique
characteristics
such
as
high
water
content,
biocompatibility,
ability
encapsulate
both
hydrophilic
hydrophobic
molecules.
The
review
explores
synthesis,
structural
configurations,
stimuli‐responsive
nature
nanogels,
highlighting
their
adaptability
targeted
including
across
challenging
barriers
like
blood–brain
barrier.
Furthermore,
paper
delves
into
applications
particularly
delivery
systems,
demonstrating
potential
revolutionize
these
fields.
Despite
promising
preclinical
results,
challenges
remain
translating
technologies
clinical
practice,
issues
related
stability,
scalability,
regulatory
approval.
concludes
by
discussing
future
perspectives,
emphasizing
need
further
research
optimize
ultimately
aiming
enhance
efficacy
safety
settings.
International Dental Journal,
Год журнала:
2024,
Номер
74(3), С. 500 - 509
Опубликована: Апрель 1, 2024
To
study
the
relationships
of
serum
25-hydroxyvitamin
D
[25(OH)D]
with
dental
caries
and
periodontitis
in
a
general
Norwegian
adult
population.
We
analysed
subsample
1605
participants
from
Trøndelag
Health
Study
(HUNT)
Norway
that
had
25(OH)D)
levels
measured
HUNT3
(2006-08)
oral
health
assessed
HUNT4
Oral
(2017-19).
Negative
binomial
Poisson
regression
models
were
used
to
estimate
ratios
means
(RMs;
for
count
outcomes)
prevalence
(PRs;
dichotomous
outcomes).
Serum
25(OH)D
was
inversely
associated
number
decayed
teeth
dose-response
gradient
(<30.0
nmol/L:
RM
1.41,
95%
CI
1.07-1.85;
30.0-49.9
1.14,
0.98-1.32
≥75.0
0.84,
0.67-1.04,
as
compared
50.0-74.9
nmol/L
group,
P
trend
<.001).
Each
25
decrease
level
15%
(RM
1.15,
1.05-1.26)
increase
mean
teeth.
<30.0
35%
higher
severe
(PR
1.35,
1.00-1.83).
No
association
observed
between
natural
The
present
suggested
an
inverse
teeth,
<30
this
Pathogens,
Год журнала:
2023,
Номер
12(9), С. 1180 - 1180
Опубликована: Сен. 20, 2023
The
active
form
of
vitamin
D
is
the
hormonally
1,25(OH)2D3
(Vit
D)
vitamin,
which
plays
an
important
role
in
bone
biology
and
host
immunity.
receptor
(VDR)
a
nuclear
ligand-dependent
transcription
factor
expressed
by
many
cells.
Ligation
VDR
VitD
regulates
wide
plethora
genes
physiologic
functions
through
formation
complex
Vit
D-VDR
signaling
cascade.
influence
immune
response
to
microbial
infection
has
been
interest
researchers.
This
particularly
oral
health
diseases,
as
mucosa
exposed
microbiota,
with
certain
species
capable
causing
disruption
homeostasis.
In
this
review,
we
focus
on
modulatory
roles
degenerative
disease,
periodontitis.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115795 - 115795
Опубликована: Ноя. 2, 2023
Platelet-rich
fibrin
(PRF),
as
an
autologous
blood
preparation,
has
been
receiving
increasing
attention
in
recent
years
and
successfully
applied
various
clinical
treatments
for
alveolar
bone
regeneration
the
oral
field.
This
review
focuses
on
analyzing
summarizing
role
mechanism
of
PRF
regeneration.
We
first
provide
a
brief
introduction
to
PRF,
then
summarize
mechanisms
by
which
promotes
from
three
aspects:
osteogenesis
mechanism,
induction
conduction
involving
multiple
signaling
pathways
such
Smad,
ERK1/2,
PI3K/Akt,
Wnt/β-catenin.
also
explore
roles
scaffold,
filler,
combination
with
graft
materials,
detailing
how
provides
wealth
experimental
evidence.
Finally,
we
current
applications
fields.
The
is
becoming
increasingly
important,
its
are
more
research
understanding.
article
will
reference
significant
value
related
exploration
may
lead
discovery
new
therapeutic
targets
development
effective
efficient
treatment
strategies.
