Epilepsia, Год журнала: 2024, Номер unknown
Опубликована: Окт. 16, 2024
Despite growing interest in the potential use of exogenous ketones for treatment epilepsy, their impact on seizures and gut microbiome mycobiome remain unclear.
Язык: Английский
Frontiers in Cellular Neuroscience, Год журнала: 2025, Номер 18
Опубликована: Янв. 8, 2025
The human gut mycobiome, a minor but integral component of the microbiome, has emerged as significant player in host homeostasis and disease development. While bacteria have traditionally been focus microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play crucial role modulating health, particularly neuropsychiatric disorders. This review aims to provide comprehensive overview current knowledge on relationship between mycobiome disorders, exploring potential targeting novel therapeutic strategy. We summarized findings from metagenomic analyses characterize diversity composition mycobiota discuss how these interact with other microorganisms via gut-brain axis. Key methodologies for studying mycobiota, such high-throughout sequencing bioinformatics approaches, were reviewed highlight advances field. Emerging research links dysbiosis conditions schizophrenia, Alzheimer's disease, autism spectrum bipolar disorder, depression. Studies indicate specific populations, Candida Saccharomyces, influence neuroinflammation, permeability immune responses, thereby affecting mental health outcomes. Understanding mycobiome's disorders opens new avenues interventions, including antifungal treatments, probiotics, dietary modifications. Future should integrate multi-omics approaches unravel complex interkingdom interactions within ecosystem, paving way personalized medicine care.
Язык: Английский
Процитировано
3
Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер 24(4), С. 259 - 271
Опубликована: Март 20, 2024
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental conditions and highly heterogeneous in terms symptom profile, associated cognitive deficits, comorbidities, outcomes. Heterogeneity may also affect ability to recognize diagnose this condition. The diagnosis ADHD primarily clinical but there are increasing research efforts aiming at identifying biomarkers that can aid diagnosis.
Язык: Английский
Процитировано
10
Journal of Fungi, Год журнала: 2024, Номер 10(3), С. 192 - 192
Опубликована: Март 1, 2024
This review explores the ‘gut–lung axis’ in asthma with a focus on commensal fungal organisms. We explore how changes to intestinal community composition alter lung immune function. comprehensively available studies that have profiled of gut mycobiome adults and children asthma, discuss mechanisms gut–lung interactions been described animal models asthma. Studies indicate dysbiosis, such as an increased abundance certain fungi like Candida, can elevate risk exacerbate it adults. effect is mediated through various pathways: host system’s sensing dysbiosis via C-type lectin receptors (e.g., Dectin-2), impact pro-inflammatory metabolites 12,13-diHOME, prostaglandin E2), role cells group 2 innate lymphoid [ILC2], M2 macrophages). also describe strategies for modulating potential therapies severe The concludes by emphasizing necessity further research into deepen our understanding these complex interactions.
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2024, Номер 16(14), С. 2260 - 2260
Опубликована: Июль 13, 2024
We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving stable dose methylphenidate (MPH) treatment enrolled and randomly assigned two groups: one add-on Bf-688 (daily bacterial count 5 × 109 CFUs) (n = 51) other placebo 51). All participants underwent assessments using Conners’ Continuous Performance Test (CPT) Auditory Attention (CATA). Additionally, fecal samples collected at beginning (week 0) endpoint 12). Remarkably, group supplementation, but not group, exhibited significant improvements in omission errors CPT as well Hit reaction time both CATA. Gut microbiome analysis revealed increase Firmicutes Bacteroidetes ratio (F/B ratio) only group. Furthermore, we identified negative correlations between N-Glycan biosynthesis Our results demonstrate that probiotic supplement can enhance neuropsychological performance children ADHD, possibly by altering composition gut microbiota, ultimately leading reduced biosynthesis.
Язык: Английский
Процитировано
6
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
5
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Сен. 13, 2024
Major depressive disorder is a condition involving microbiota-gut-brain axis dysfunction. Increasing research aims to improve depression through gut microbiota regulation, including interventions such as probiotics, prebiotics, and fecal transplants. However, most focuses on exogenous induced by chronic stress or drugs, with less attention given endogenous depression. Additionally, mycobiota in significantly than that bacteria.
Язык: Английский
Процитировано
4
The Kaohsiung Journal of Medical Sciences, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric condition among children and adolescents, often associated with high risk of comorbidities. Currently, ADHD diagnosis relies exclusively on clinical presentation patient history, underscoring the need for clinically relevant, reliable, objective biomarkers. Such biomarkers may enable earlier lead to improved treatment outcomes. Our research team has focused identifying potential by investigating its possible pathomechanisms, consideration aforementioned criteria. Given significant sex-related differences in prevalence (male predominance) age-related variability symptomatology, we explored role neuroendocrine systems ADHD. Specifically, examined epigenetic regulation mechanism involved pathogenesis developed diagnostic model based peripheral microRNA. Additionally, investigated microbiota dysbiosis pathophysiology provided novel insights into management. This paper presents summary our findings By analyzing blood, salivary, fecal samples, identified several promising that serve as parameters improving accuracy Further involving larger cohort studies required confirm reliability these
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Янв. 29, 2025
Attention Deficit Hyperactivity Disorder (ADHD) is a clinically common neurodevelopmental disorder of the brain. In addition to genetic factors, an imbalance in gut flora may also play role development ADHD. Currently, it critical investigate function and related metabolites, which form fundamental basis bidirectional cross-linking between brain gut, focusing on changed This study aimed possible relationship changes metabolites ADHD by analyzing metagenome untargeted metabolomics fecal samples from patients. Specifically, we attempted identify key metabolic pathways they are involved in, as well analyze detail structure composition order further symptoms, some behavioral studies were conducted following transplantation patients into rats. The results analysis revealed several distinct strains, including Bacteroides cellulosilyticus , could be important for diagnosing Additionally, group showed modifications nicotinamide nicotinic acid metabolite this pathway. demonstrated that rats with transplants displayed increased locomotor activity interest, indicating onset behaviors such facilitated associated research verified alterations metabolism observed provided list significantly altered Simultaneously, our findings microbiome potentially trigger animals, providing experimental comprehending influence These might provide new perspectives novel treatment strategies.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 297 - 323
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Fungi, Год журнала: 2025, Номер 11(4), С. 279 - 279
Опубликована: Апрель 2, 2025
The human gastrointestinal tract harbors a vast array of microorganisms, which play essential roles in maintaining metabolic balance and immune function. While bacteria dominate the gut microbiome, fungi represent much smaller, often overlooked fraction. Despite their relatively low abundance, may significantly influence both health disease. Advances next-generation sequencing, metagenomics, metatranscriptomics, metaproteomics, metabolomics, computational biology have provided novel opportunities to study mycobiome, shedding light on its composition, functional genes, metabolite interactions. Emerging evidence links fungal dysbiosis various diseases, including inflammatory bowel disease, colorectal cancer, disorders, neurological conditions. mycobiome also presents promising avenue for precision medicine, particularly biomarker discovery, disease diagnostics, targeted therapeutics. Nonetheless, significant challenges remain effectively integrating knowledge into clinical practice. This review examines microbiota, highlighting analytical methods, associations with potential role medicine. It discusses pathways translation, diagnosis treatment, while addressing key barriers implementation.
Язык: Английский
Процитировано
0