Current Neurovascular Research, Год журнала: 2023, Номер 20(4), С. 429 - 433
Опубликована: Сен. 28, 2023
Язык: Английский
Diabetes Metabolic Syndrome and Obesity, Год журнала: 2024, Номер Volume 17, С. 1289 - 1299
Опубликована: Март 1, 2024
Abstract: Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis complex not fully understood. Podocytes, glomerular endothelial cells (GECs), mesangial (GMCs) tubular epithelial (TECs) play important roles normal function glomerulus tubules, their injury involved progression DN. Although our understanding mechanisms leading to DN has substantially improved, we still need find more effective therapeutic targets. Autophagy, pyroptosis ferroptosis are programmed cell death processes that associated with inflammation closely related a variety diseases. Recently, growing number studies have reported autophagy, regulate podocytes, GECs, GMCs TECs. This review highlights contributions pyroptosis, these cells, offering potential targets for treatment. Keywords: diabetic nephropathy, ferroptosis,
Язык: Английский
Процитировано
13
Cancer Cell International, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 18, 2024
Abstract One of the key features cancer is energy metabolic reprogramming which tightly related to proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class RNAs having no protein-coding potential mainly include microRNAs, lncRNAs circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating reprogramming, altered networks mediated by primarily drive carcinogenesis expression enzymes transporter proteins. Importantly, accumulated research revealed dysregulated mediate contributing generation therapeutic tolerance. Elucidating molecular mechanism can provide promising metabolism-related targets for treatment as well overcome In conclusion, this review updates latest mechanisms reprogramming.
Язык: Английский
Процитировано
10
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Май 23, 2024
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related
Язык: Английский
Процитировано
10
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
1
Journal of Diabetes Investigation, Год журнала: 2024, Номер 15(8), С. 1003 - 1016
Опубликована: Апрель 22, 2024
Tanshinone IIA (TIIA) is one of the main components root red-rooted Salvia miltiorrhiza Bunge. However, molecular mechanisms underlying TIIA-mediated protective effects in diabetic nephropathy (DN) are still unclear.
Язык: Английский
Процитировано
8
Cells, Год журнала: 2023, Номер 12(22), С. 2595 - 2595
Опубликована: Ноя. 9, 2023
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world are insidious in onset, chronic nature, yield significant disability death. Current therapies that address nutritional status, weight management, pharmacological options may delay but cannot alter disease course or functional organ loss, such as dementia degeneration of systemic bodily functions. Underlying these challenges onset aging associated with increased lifespan, telomere dysfunction, oxidative stress generation lead to multi-system dysfunction. These hurdles point urgent need underlying mechanisms innovative applications. New treatment strategies involve non-coding RNA pathways microRNAs (miRNAs) circular ribonucleic acids (circRNAs), Wnt signaling, Wnt1 inducible signaling pathway protein 1 (WISP1) dependent upon programmed cell death pathways, cellular metabolic AMP-activated kinase (AMPK) nicotinamide, growth factor Non-coding RNAs, AMPK cornerstone for overseeing complex offer avenues DM will necessitate continued appreciation ability each independently unison influence clinical outcome.
Язык: Английский
Процитировано
11
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131961 - 131961
Опубликована: Апрель 29, 2024
Язык: Английский
Процитировано
4
Journal of Diabetes, Год журнала: 2024, Номер 16(6)
Опубликована: Май 16, 2024
Abstract Background Diabetic nephropathy (DN) is a diabetic complication. LncRNAs are reported to participate in the pathophysiology of DN. Here, function and mechanism lncRNA small nucleolar RNA host gene 14 ( SNHG14 ) DN were explored. Methods Streptozotocin (STZ)‐induced mouse models high glucose (HG)‐treated human mesangial cells (MCs) used detect expression. silencing plasmids applied examine on proliferation fibrosis HG‐treated MCs. Potential targets predicted using bioinformatics tools verified by luciferase reporter, pulldown, northern blotting assays. The functional role vivo was detected injection with adenoviral vector carrying sh‐ into mice. Serum creatinine, blood urea nitrogen, glucose, 24‐h proteinuria, relative kidney weight, renal pathological changes examined Results expression elevated kidneys mice inhibited HG‐stimulated bound miR‐30e‐5p upregulate SOX4 In rescue assays, elevation diminished effects MCs, reversed overexpression. studies, downregulation significantly ameliorated injuries interstitial Conclusions attenuates injury reduces fibrotic phenotype MCs via / axis. image
Язык: Английский
Процитировано
4
Acta Physiologica, Год журнала: 2024, Номер 240(7)
Опубликована: Май 20, 2024
Ferroptosis is a novel type of programmed cell death that performs critical function in diabetic nephropathy (DN). Augmenter liver regeneration (ALR) exists the inner membrane mitochondria, and inhibits inflammation, apoptosis, oxidative stress acute kidney injury; however, its role DN remains unexplored. Here, we aimed to identify ALR ferroptosis induction macrophage activation DN.
Язык: Английский
Процитировано
4
Diabetic Medicine, Год журнала: 2024, Номер 41(9)
Опубликована: Июнь 17, 2024
Abstract Aim Impaired wound healing in patients with diabetes can develop into nonhealing ulcerations. Because bone marrow mesenchymal stem cells (BMSCs) exosomes promote healing, this study aims to investigate the mechanism of BMSCs‐isolated exosomal miR‐221‐3p angiogenesis and diabetic healing. Methods To mimic vitro, human umbilical vein endothelial (HUVECs) were subjected high glucose (HG). Exosomes derived from BMSCs identified by transmission electron microscopy (TEM), western blot analysis dynamic light scattering (DLS). The ability differentiate was assessed via Oil red O staining, alkaline phosphatase (ALP) staining alizarin staining. internalise PKH26‐labelled using confocal microscopy. Migration, cell viability tested scratch, MTT tube formation assays separately. miRNA protein levels analysed quantitative reverse transcriptase polymerase chain reaction (qRT‐PCR) or blotting. relationship among miR‐221‐3p, FOXP1 SPRY1 determined dual‐luciferase reporter, ChIP RIP assays. Results Exosomal successfully isolated delivered HUVECs. HG found suppress angiogenesis, migration HUVECs separated inhibited above phenomenon. could transcriptionally upregulate SPRY1, silencing reversed HG‐stimulated inhibition, downregulation SPRY1. Meanwhile, directly targeted overexpression positive effect on HUVEC angiogenesis. Conclusion promoted wounds through mediation FOXP1/SPRY1 axis. Furthermore, findings provide new insights probing strategies against diabetes.
Язык: Английский
Процитировано
3