Cellular senescence: Searching for the philosopher's stone DOI Open Access
Zoe Diana Draelos,

A. Ortiz Brugués

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 3 - 4

Опубликована: Июнь 17, 2024

Skin aging and photoaging are major issues in dermatology, impacting not only the appearance of skin but also function susceptibility to disease, as well mental health well-being. The physiological changes occurring determined by genetic intrinsic factors, influenced a combination multiple extrinsic particularly sun exposure. Advances research have led mechanistic approach development more sophisticated anti-aging treatments that target cellular processes improve appearance. However, range active ingredients with reported efficacy continues expand, trends on social media resulting consumers becoming aware targeted effects specific compounds, dermatologists need ensure their patients receiving most appropriate treatments, developed through evidence-based approaches patient safety meet individual needs. advances, challenges country-specific were among key topics discussed at meetings 'Cellular Senescence: Searching for Philosopher's Stone' held 18 November 2022 Cancun 09 December Sydney, which gathered together groups international experts from various fields, including regenerative medicine biotherapy, pharmacology, dermatology. supported an unrestricted educational grant Pierre Fabre Dermo-Cosmétique/Laboratoires Dermatologiques Avène, France. This journal supplement summarizes highlights this meeting. first review Jean-Marc Lemaitre1 focuses recent advances identification characterization epigenetic alterations senescence, especially senescence-associated secretory phenotype (SASP), important hallmarks targets potential interventions preventing or treating age-related pathologies. Indeed, these shift attitude toward treatment underlying cause emphasis developing prevent delay clear senescent cells mitigate SASP factors combinations healthy lifestyle use senolytics senomorphics, techniques promote tissue rejuvenation stimulation aged stem reprogramming deprogrammed cells. In skin, both chronological associated accumulation increased production metalloproteinases proinflammatory cytokines, dysfunction degradation extracellular matrix lead characteristic signs aging, such thinning epidermis cornified layer, disorganization mechanical fibres dermis, hyperpigmentation. focus Zoe Draelos, Patrick Bogdanowicz Jean-Hilaire Saurat2 is describe molecular mechanisms action clinical effectiveness core group topical products (hyaluronic acid, retinaldehyde, vitamins C E niacinamide), mitigating impact senescence improving function, been shown health. multilevel strategies, combining effective care remodelling different layers topic Kui Young Park Ingrid López Gehrke.3 authors outline commonly used ranging injections fillers biostimulators into deep fat layer hypodermis non-ablative resurfacing lasers dermis subcutaneous tissue, combined cosmeceuticals adjuvants prepare accelerate recovery sustain results. Australia Brazil, where levels exposure high populations predominantly outdoor lifestyles, risk cancer concerns. countries, it essential strategies combat improvements appearance, help occurrence pre-malignant lesions. Greg Goodman Edileia Bagatin4 describes general process characteristics photoaging, highlighting prominent features photo-exposed describing solutions photoaged preventive measures, cosmetic procedures. Finally, SARS-CoV-2 pandemic had many countries access in-clinic aesthetic Analysis since country emerged successive SARS-CoV-2-related lockdowns, summarized final Leona Yip,5 provides valuable insights driving popularity non-surgical procedures, natural organic products. rise wellness movement ideal opportunity encourage adopt holistic includes taking against all exposome. covered during two series articles progress being made field anti-aging. Thus, far searching philosopher's stone gain immortality eternal youth cure we now looking preventative measures wellbeing. As new developed, adapted needs populations, keep pace make better alternative platforms, media, receive safe information skin. We sincerely hope you will enjoy reading issue much enjoyed attending Sydney. thank Emma Pilling, PhD Marielle Romet, (Synergy Pharm-Santé Active Edition) who provided medical writing assistance. Draelos received honoraria Dermo-Cosmétique speaker Entretiens d'Avène, consulting fees SkinBetter Science NuSkin grants Kenvue L'Oreal. Ariadna Ortiz Brugués was employee time foreword. Data sharing applicable article no datasets generated analyzed.

Язык: Английский

Top weapons in skin aging and actives to target the consequences of skin cell senescence DOI Creative Commons
Zoe Diana Draelos, Patrick Bogdanowicz, J.‐H. Saurat

и другие.

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 15 - 22

Опубликована: Июнь 17, 2024

Abstract Skin aging has long been considered a purely cosmetic problem. However, as life expectancy increases, skin is taking on functional dimension that goes beyond cosmetics and appearance. Preventive or therapeutic strategies are needed to target cellular senescence, key process underlying the alterations in function appearance occur with aging, well address age‐related changes associated ‘dermatoporosis’ chronic insufficiency/fragility syndrome. Thus, given need for effective anti‐aging products improve both of skin, it essential distinguish active ingredients have proven be effective, among large number available over‐the‐counter cosmeceuticals. This brief review focuses core group topical actives, describing their clinical effects senescence molecular mechanisms action. These actives include hyaluronic acid, which hydrating viscoelastic properties shown reduce atrophy; retinaldehyde, activates retinoid receptors increases cutaneous elasticity; vitamins C E, provide stable oxidative protection; niacinamide, reduces inflammation mitigates senescence.

Язык: Английский

Процитировано

9
The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications DOI Creative Commons

Ting Zhang,

Zhou Li-jun, Meagan J. Makarczyk

и другие.

Molecules, Год журнала: 2025, Номер 30(4), С. 816 - 816

Опубликована: Фев. 10, 2025

Aging represents a complex biological phenomenon marked by the progressive deterioration of physiological functions over time, reduced resilience, and increased vulnerability to age-related diseases, ultimately culminating in mortality. Recent research has uncovered diverse molecular mechanisms through which metformin extends its benefits beyond glycemic control, presenting it as promising intervention against aging. This review delves into anti-aging properties metformin, highlighting role mitochondrial energy modulation, activation AMPK-mTOR signaling pathway, stimulation autophagy, mitigation inflammation linked cellular Furthermore, we discuss influence on epigenetic modifications that underpin genomic stability homeostasis. Metformin's potential addressing age-associated disorders including metabolic, cardiovascular, neurodegenerative diseases is also explored. The Targeting with Metformin (TAME) trial aims provide key evidence efficacy delaying aging humans. Despite these insights, significant challenges persist gaining more comprehensive understanding underlying mechanisms, determining optimal dosing strategies, evaluating long-term safety non-diabetic populations. Addressing crucial fully realizing metformin's an therapeutic.

Язык: Английский

Процитировано

1
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene DOI Creative Commons
Yijing Tao, Chengjie Gao, Juan Wang

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0318574 - e0318574

Опубликована: Март 10, 2025

Objective Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative characterized by the accumulation of calcium deposits in valve. We aim to screen key genes associated with cellular senescence (CS) CAVD. Methods The GSE12644 and GSE51472 datasets from GEO database was utilized this study, differentially expressed (DEGs) were identified using “ limma ” R package. CS-related DEGs (CS-DEGs) determined through CellAge database. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses performed on CS-DEGs. A protein–protein interaction (PPI) network constructed STRING cytoHubba plug-in Cytoscape used identify hub genes. noncoding-RNA-mRNA regulatory established. DSigDB drugs potentially be useful for treating Results total 16 CS-DEGs identified. These primarily collagen metabolic process, catabolic process external side plasma membrane. 10 as regulators CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. Noncoding RNA-mRNA indicated that may regulated noncoding RNAs. β-Carotene, naturally occurring carotenoid antioxidant properties, potential therapeutic agents interacting MMP9, CTSB. Conclusion This study provides insights into pathways related CAVD (MMP9, CTSB) highlights role β-Carotene treatment

Язык: Английский

Процитировано

0
Photoaging and cosmeceutical solutions in sun‐overexposed countries: The experience of Australia and Brazil DOI Open Access
Greg J. Goodman, Ediléia Bagatin

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 36 - 44

Опубликована: Июнь 17, 2024

Abstract Skin aging is the result of physiological changes determined by genetically driven processes and intrinsic factors, exacerbated a combination multiple environmental main one being sun exposure. The effects photoaging are particularly apparent on face, where appearance signs can have significant impact emotions conveyed well‐being. Photoprotection facial skin care for managing thus particular importance both physical mental health. Countries, like Australia Brazil, level exposure high populations predominantly outdoor lifestyles, aware harms implemented several measures to help reduce risk cancer in their populations. However, sun‐seeking behaviours difficult change, it takes time before interventions provide perceptible results. still has some highest incidence mortality rates world. Solutions that target individuals also be used minimizing clinical improving quality, with ultimate aim not only improve but mitigate occurrence pre‐malignant malignant lesions. This review summarizes features photo‐exposed populations, based evidence gained from studies Australian individuals, discusses various available solutions photoaging, those most popular which country many years experience photoaged skin.

Язык: Английский

Процитировано

3
Cellular Senescence and Anti-Aging Strategies in Aesthetic Medicine: A Bibliometric Analysis and Brief Review DOI Creative Commons

Huilan Zheng,

Jingping Wu,

Jinhong Feng

и другие.

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2243 - 2259

Опубликована: Окт. 1, 2024

Background: Skin aging is the most obvious feature of human aging, and delaying has become a hot difficult research topic in aesthetic medicine. The accumulation dysfunctional senescent cells one important mechanisms skin based on which series anti-aging strategies have been generated. In this paper, from perspective cellular senescence, we utilize bibliometrics review to explore hotspots trends field, with view providing references for health Methods: We obtained literature related field Web Science Core Collection database 1994 2024. Bibliometrix packages R, CiteSpace, VOSviewer, Origin, Scimago Graphica were utilized data mining visualization. Results: A total 2,796 documents included analysis. overall trend publications showed continuous rapid increase 2016– 2023, but citations improved poorly over time. Journal Cosmetic Dermatology, Investigative Experimental Gerontology are core journals. Kim J, Lee JH, S, Rattan SIS, Chung JH authors field. Seoul National University first terms publications. Korea country publications, USA citations. Top 10 keywords include: gene-expression, skin, cell, oxidative stress, antioxidants, vitro, fibroblasts, mechanism, cancer. Current focused neurodegeneration, rejuvenation, molecular docking, fibrosis, wound healing, SASP, barrier, antioxidants. reflect topics such as major pathways process, relationship tumors. Conclusion: This rapidly rising recent years. Relevant focus senescence-associated secretory phenotype. Anti-aging targeting senescence hold great promise, including removal or attenuation SASP factors, corresponding senolytics senomorphics therapies, respectively. Keywords: medicine, senolytic,

Язык: Английский

Процитировано

1
Attenuated NIX in impaired mitophagy contributes to exacerbating cellular senescence in experimental periodontitis under hyperglycemic conditions DOI Open Access

Danni Song,

Beibei Chen, Tianfan Cheng

и другие.

FEBS Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Premature accumulation of senescent cells results in tissue destruction, and it is one the potential primary mechanisms underlying accelerated progression diabetes periodontitis. However, whether this characterized phenomenon could account for periodontal pathogenesis under hyperglycemic conditions remains unclear. In study, we assessed phenotypic changes experimental periodontitis conditions. Next, investigated mitochondrial function mitophagy pathways cellular senescence vitro vivo. Our findings showed that significant occurred gingival tissues diabetic mice with increased expression senescence-related protein p21

Язык: Английский

Процитировано

1
Cellular senescence: Searching for the philosopher's stone DOI Open Access
Zoe Diana Draelos,

A. Ortiz Brugués

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 3 - 4

Опубликована: Июнь 17, 2024

Skin aging and photoaging are major issues in dermatology, impacting not only the appearance of skin but also function susceptibility to disease, as well mental health well-being. The physiological changes occurring determined by genetic intrinsic factors, influenced a combination multiple extrinsic particularly sun exposure. Advances research have led mechanistic approach development more sophisticated anti-aging treatments that target cellular processes improve appearance. However, range active ingredients with reported efficacy continues expand, trends on social media resulting consumers becoming aware targeted effects specific compounds, dermatologists need ensure their patients receiving most appropriate treatments, developed through evidence-based approaches patient safety meet individual needs. advances, challenges country-specific were among key topics discussed at meetings 'Cellular Senescence: Searching for Philosopher's Stone' held 18 November 2022 Cancun 09 December Sydney, which gathered together groups international experts from various fields, including regenerative medicine biotherapy, pharmacology, dermatology. supported an unrestricted educational grant Pierre Fabre Dermo-Cosmétique/Laboratoires Dermatologiques Avène, France. This journal supplement summarizes highlights this meeting. first review Jean-Marc Lemaitre1 focuses recent advances identification characterization epigenetic alterations senescence, especially senescence-associated secretory phenotype (SASP), important hallmarks targets potential interventions preventing or treating age-related pathologies. Indeed, these shift attitude toward treatment underlying cause emphasis developing prevent delay clear senescent cells mitigate SASP factors combinations healthy lifestyle use senolytics senomorphics, techniques promote tissue rejuvenation stimulation aged stem reprogramming deprogrammed cells. In skin, both chronological associated accumulation increased production metalloproteinases proinflammatory cytokines, dysfunction degradation extracellular matrix lead characteristic signs aging, such thinning epidermis cornified layer, disorganization mechanical fibres dermis, hyperpigmentation. focus Zoe Draelos, Patrick Bogdanowicz Jean-Hilaire Saurat2 is describe molecular mechanisms action clinical effectiveness core group topical products (hyaluronic acid, retinaldehyde, vitamins C E niacinamide), mitigating impact senescence improving function, been shown health. multilevel strategies, combining effective care remodelling different layers topic Kui Young Park Ingrid López Gehrke.3 authors outline commonly used ranging injections fillers biostimulators into deep fat layer hypodermis non-ablative resurfacing lasers dermis subcutaneous tissue, combined cosmeceuticals adjuvants prepare accelerate recovery sustain results. Australia Brazil, where levels exposure high populations predominantly outdoor lifestyles, risk cancer concerns. countries, it essential strategies combat improvements appearance, help occurrence pre-malignant lesions. Greg Goodman Edileia Bagatin4 describes general process characteristics photoaging, highlighting prominent features photo-exposed describing solutions photoaged preventive measures, cosmetic procedures. Finally, SARS-CoV-2 pandemic had many countries access in-clinic aesthetic Analysis since country emerged successive SARS-CoV-2-related lockdowns, summarized final Leona Yip,5 provides valuable insights driving popularity non-surgical procedures, natural organic products. rise wellness movement ideal opportunity encourage adopt holistic includes taking against all exposome. covered during two series articles progress being made field anti-aging. Thus, far searching philosopher's stone gain immortality eternal youth cure we now looking preventative measures wellbeing. As new developed, adapted needs populations, keep pace make better alternative platforms, media, receive safe information skin. We sincerely hope you will enjoy reading issue much enjoyed attending Sydney. thank Emma Pilling, PhD Marielle Romet, (Synergy Pharm-Santé Active Edition) who provided medical writing assistance. Draelos received honoraria Dermo-Cosmétique speaker Entretiens d'Avène, consulting fees SkinBetter Science NuSkin grants Kenvue L'Oreal. Ariadna Ortiz Brugués was employee time foreword. Data sharing applicable article no datasets generated analyzed.

Язык: Английский

Процитировано

0