Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 3 - 4
Опубликована: Июнь 17, 2024
Skin aging and photoaging are major issues in dermatology, impacting not only the appearance of skin but also function susceptibility to disease, as well mental health well-being. The physiological changes occurring determined by genetic intrinsic factors, influenced a combination multiple extrinsic particularly sun exposure. Advances research have led mechanistic approach development more sophisticated anti-aging treatments that target cellular processes improve appearance. However, range active ingredients with reported efficacy continues expand, trends on social media resulting consumers becoming aware targeted effects specific compounds, dermatologists need ensure their patients receiving most appropriate treatments, developed through evidence-based approaches patient safety meet individual needs. advances, challenges country-specific were among key topics discussed at meetings 'Cellular Senescence: Searching for Philosopher's Stone' held 18 November 2022 Cancun 09 December Sydney, which gathered together groups international experts from various fields, including regenerative medicine biotherapy, pharmacology, dermatology. supported an unrestricted educational grant Pierre Fabre Dermo-Cosmétique/Laboratoires Dermatologiques Avène, France. This journal supplement summarizes highlights this meeting. first review Jean-Marc Lemaitre1 focuses recent advances identification characterization epigenetic alterations senescence, especially senescence-associated secretory phenotype (SASP), important hallmarks targets potential interventions preventing or treating age-related pathologies. Indeed, these shift attitude toward treatment underlying cause emphasis developing prevent delay clear senescent cells mitigate SASP factors combinations healthy lifestyle use senolytics senomorphics, techniques promote tissue rejuvenation stimulation aged stem reprogramming deprogrammed cells. In skin, both chronological associated accumulation increased production metalloproteinases proinflammatory cytokines, dysfunction degradation extracellular matrix lead characteristic signs aging, such thinning epidermis cornified layer, disorganization mechanical fibres dermis, hyperpigmentation. focus Zoe Draelos, Patrick Bogdanowicz Jean-Hilaire Saurat2 is describe molecular mechanisms action clinical effectiveness core group topical products (hyaluronic acid, retinaldehyde, vitamins C E niacinamide), mitigating impact senescence improving function, been shown health. multilevel strategies, combining effective care remodelling different layers topic Kui Young Park Ingrid López Gehrke.3 authors outline commonly used ranging injections fillers biostimulators into deep fat layer hypodermis non-ablative resurfacing lasers dermis subcutaneous tissue, combined cosmeceuticals adjuvants prepare accelerate recovery sustain results. Australia Brazil, where levels exposure high populations predominantly outdoor lifestyles, risk cancer concerns. countries, it essential strategies combat improvements appearance, help occurrence pre-malignant lesions. Greg Goodman Edileia Bagatin4 describes general process characteristics photoaging, highlighting prominent features photo-exposed describing solutions photoaged preventive measures, cosmetic procedures. Finally, SARS-CoV-2 pandemic had many countries access in-clinic aesthetic Analysis since country emerged successive SARS-CoV-2-related lockdowns, summarized final Leona Yip,5 provides valuable insights driving popularity non-surgical procedures, natural organic products. rise wellness movement ideal opportunity encourage adopt holistic includes taking against all exposome. covered during two series articles progress being made field anti-aging. Thus, far searching philosopher's stone gain immortality eternal youth cure we now looking preventative measures wellbeing. As new developed, adapted needs populations, keep pace make better alternative platforms, media, receive safe information skin. We sincerely hope you will enjoy reading issue much enjoyed attending Sydney. thank Emma Pilling, PhD Marielle Romet, (Synergy Pharm-Santé Active Edition) who provided medical writing assistance. Draelos received honoraria Dermo-Cosmétique speaker Entretiens d'Avène, consulting fees SkinBetter Science NuSkin grants Kenvue L'Oreal. Ariadna Ortiz Brugués was employee time foreword. Data sharing applicable article no datasets generated analyzed.
Язык: Английский
