Cellular senescence: Searching for the philosopher's stone DOI Open Access
Zoe Diana Draelos,

A. Ortiz Brugués

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 3 - 4

Опубликована: Июнь 17, 2024

Skin aging and photoaging are major issues in dermatology, impacting not only the appearance of skin but also function susceptibility to disease, as well mental health well-being. The physiological changes occurring determined by genetic intrinsic factors, influenced a combination multiple extrinsic particularly sun exposure. Advances research have led mechanistic approach development more sophisticated anti-aging treatments that target cellular processes improve appearance. However, range active ingredients with reported efficacy continues expand, trends on social media resulting consumers becoming aware targeted effects specific compounds, dermatologists need ensure their patients receiving most appropriate treatments, developed through evidence-based approaches patient safety meet individual needs. advances, challenges country-specific were among key topics discussed at meetings 'Cellular Senescence: Searching for Philosopher's Stone' held 18 November 2022 Cancun 09 December Sydney, which gathered together groups international experts from various fields, including regenerative medicine biotherapy, pharmacology, dermatology. supported an unrestricted educational grant Pierre Fabre Dermo-Cosmétique/Laboratoires Dermatologiques Avène, France. This journal supplement summarizes highlights this meeting. first review Jean-Marc Lemaitre1 focuses recent advances identification characterization epigenetic alterations senescence, especially senescence-associated secretory phenotype (SASP), important hallmarks targets potential interventions preventing or treating age-related pathologies. Indeed, these shift attitude toward treatment underlying cause emphasis developing prevent delay clear senescent cells mitigate SASP factors combinations healthy lifestyle use senolytics senomorphics, techniques promote tissue rejuvenation stimulation aged stem reprogramming deprogrammed cells. In skin, both chronological associated accumulation increased production metalloproteinases proinflammatory cytokines, dysfunction degradation extracellular matrix lead characteristic signs aging, such thinning epidermis cornified layer, disorganization mechanical fibres dermis, hyperpigmentation. focus Zoe Draelos, Patrick Bogdanowicz Jean-Hilaire Saurat2 is describe molecular mechanisms action clinical effectiveness core group topical products (hyaluronic acid, retinaldehyde, vitamins C E niacinamide), mitigating impact senescence improving function, been shown health. multilevel strategies, combining effective care remodelling different layers topic Kui Young Park Ingrid López Gehrke.3 authors outline commonly used ranging injections fillers biostimulators into deep fat layer hypodermis non-ablative resurfacing lasers dermis subcutaneous tissue, combined cosmeceuticals adjuvants prepare accelerate recovery sustain results. Australia Brazil, where levels exposure high populations predominantly outdoor lifestyles, risk cancer concerns. countries, it essential strategies combat improvements appearance, help occurrence pre-malignant lesions. Greg Goodman Edileia Bagatin4 describes general process characteristics photoaging, highlighting prominent features photo-exposed describing solutions photoaged preventive measures, cosmetic procedures. Finally, SARS-CoV-2 pandemic had many countries access in-clinic aesthetic Analysis since country emerged successive SARS-CoV-2-related lockdowns, summarized final Leona Yip,5 provides valuable insights driving popularity non-surgical procedures, natural organic products. rise wellness movement ideal opportunity encourage adopt holistic includes taking against all exposome. covered during two series articles progress being made field anti-aging. Thus, far searching philosopher's stone gain immortality eternal youth cure we now looking preventative measures wellbeing. As new developed, adapted needs populations, keep pace make better alternative platforms, media, receive safe information skin. We sincerely hope you will enjoy reading issue much enjoyed attending Sydney. thank Emma Pilling, PhD Marielle Romet, (Synergy Pharm-Santé Active Edition) who provided medical writing assistance. Draelos received honoraria Dermo-Cosmétique speaker Entretiens d'Avène, consulting fees SkinBetter Science NuSkin grants Kenvue L'Oreal. Ariadna Ortiz Brugués was employee time foreword. Data sharing applicable article no datasets generated analyzed.

Язык: Английский

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness DOI Open Access

K Lee,

K Chan,

Angela Lee

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8224 - 8224

Опубликована: Июль 27, 2024

Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims provide an overview the current practices perceived effectiveness polynucleotides medicine. A comprehensive search literature was conducted using keywords related polynucleotides, cosmetic application, application. Studies were selected based on relevance inclusion human subjects. The found that been used improve skin texture, reduce wrinkle depth, enhance facial appearance. studies reported varying degrees efficacy safety, with some demonstrating significant improvements elasticity hydration. However, others limited or no benefits. also highlighted need further research establish optimal use While existing suggests may benefits medicine, more is needed fully understand mechanisms action use. Clinicians should be aware limitations risks associated

Язык: Английский

Процитировано

8
Combined multilevel anti‐aging strategies and practical applications of dermocosmetics in aesthetic procedures DOI Open Access
Kui Young Park, Ingrid López Gehrke

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 23 - 35

Опубликована: Июнь 17, 2024

Abstract Management of the signs facial aging and other cosmetic skin problems have greatly evolved in past years. People are also seeking to improve their well‐being global appearance, when they consider using procedures, expect natural long‐lasting aesthetic results. Combined dermocosmetic approaches that address at all levels increasingly being used by dermatologists meet patient expectations while ensuring safety. Minimally invasive reversible procedures can be performed only one session popular for restructuring volumizing as flexible, rapid less burdensome patients. These interventions achieve even better outcomes combined with cosmeceuticals pre‐ or post‐procedural adjuvants prepare skin, accelerate recovery sustain The use topical dermocosmetics is recommended part daily care routine quality help maintain barrier function. This review thus outlines most commonly multilevel anti‐aging strategies, which start addressing deepest layers then more superficial aging. Examples multi‐active delivery enhancing systems presented, together examples supportive provide insights into current applications products.

Язык: Английский

Процитировано

4
Anatomy-Based Filler Injection: Treatment Techniques for Supraorbital Hollowness and Charming Roll DOI Creative Commons

Giwoong Hong,

Woo Chun Choi,

Jovian Wan

и другие.

Life, Год журнала: 2025, Номер 15(2), С. 304 - 304

Опубликована: Фев. 15, 2025

Supraorbital hollowness and pretarsal fullness, commonly known as the sunken eyelid charming roll, respectively, are significant anatomical features that impact aesthetic appearance of periorbital region. is characterized by a recessed upper eyelid, often attributed to genetic factors, aging, or surgical alterations, such excessive fat removal during blepharoplasty. This condition particularly prevalent among East Asians due differences, weaker levator muscles unique distribution patterns. Pretarsal also aegyo-sal, enhances youthful expressive lower forming roll above lash line considered aesthetically desirable in Asian culture. Anatomical-based filler injection techniques critical for correcting these features, involving precise placement within correct tissue planes avoid complications achieve natural-looking results. approach not only improves appeal but overall facial harmony, emphasizing importance tailored procedures based on individual anatomy cultural preferences.

Язык: Английский

Процитировано

0
Anatomical-Based Diagnosis and Filler Injection Techniques: Lips and Philtrum DOI Creative Commons

Gi‐Woong Hong,

Won Seok Choi, Soo Han Yoon

и другие.

Life, Год журнала: 2025, Номер 15(2), С. 315 - 315

Опубликована: Фев. 18, 2025

Lip augmentation has become increasingly popular in aesthetic medicine, driven by advancements dermal filler technologies and injection techniques. This review provides a comprehensive overview of lip anatomy, age-related changes, current best practices using fillers. The complex structure the lips, including multiple layers skin, muscle, mucosa, contributes to their unique appearance function. Age-related such as volume loss, thinning vermilion border, flattening philtrum, significantly impact aesthetics. Understanding these changes is crucial for developing effective treatment strategies. discusses importance tailoring treatments individual patient needs, considering factors ethnic variations cultural preferences. It emphasizes significance proper selection, with hyaluronic acid-based products being gold standard due biocompatibility reversibility. Injection techniques, needle cannula approaches, are described detail, focus on safety optimal outcomes. Anatomical considerations, particularly vascular supply highlighted critical avoiding complications during injections. also addresses evolving approach augmentation, which now focuses restoring natural contours addressing perioral region rather than simply increasing volume. Finally, managing expectations potential future field discussed, development more targeted refined

Язык: Английский

Процитировано

0
Photoaging and cosmeceutical solutions in sun‐overexposed countries: The experience of Australia and Brazil DOI Open Access
Greg J. Goodman, Ediléia Bagatin

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 36 - 44

Опубликована: Июнь 17, 2024

Abstract Skin aging is the result of physiological changes determined by genetically driven processes and intrinsic factors, exacerbated a combination multiple environmental main one being sun exposure. The effects photoaging are particularly apparent on face, where appearance signs can have significant impact emotions conveyed well‐being. Photoprotection facial skin care for managing thus particular importance both physical mental health. Countries, like Australia Brazil, level exposure high populations predominantly outdoor lifestyles, aware harms implemented several measures to help reduce risk cancer in their populations. However, sun‐seeking behaviours difficult change, it takes time before interventions provide perceptible results. still has some highest incidence mortality rates world. Solutions that target individuals also be used minimizing clinical improving quality, with ultimate aim not only improve but mitigate occurrence pre‐malignant malignant lesions. This review summarizes features photo‐exposed populations, based evidence gained from studies Australian individuals, discusses various available solutions photoaging, those most popular which country many years experience photoaged skin.

Язык: Английский

Процитировано

3
Cellular senescence: Searching for the philosopher's stone DOI Open Access
Zoe Diana Draelos,

A. Ortiz Brugués

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(S4), С. 3 - 4

Опубликована: Июнь 17, 2024

Skin aging and photoaging are major issues in dermatology, impacting not only the appearance of skin but also function susceptibility to disease, as well mental health well-being. The physiological changes occurring determined by genetic intrinsic factors, influenced a combination multiple extrinsic particularly sun exposure. Advances research have led mechanistic approach development more sophisticated anti-aging treatments that target cellular processes improve appearance. However, range active ingredients with reported efficacy continues expand, trends on social media resulting consumers becoming aware targeted effects specific compounds, dermatologists need ensure their patients receiving most appropriate treatments, developed through evidence-based approaches patient safety meet individual needs. advances, challenges country-specific were among key topics discussed at meetings 'Cellular Senescence: Searching for Philosopher's Stone' held 18 November 2022 Cancun 09 December Sydney, which gathered together groups international experts from various fields, including regenerative medicine biotherapy, pharmacology, dermatology. supported an unrestricted educational grant Pierre Fabre Dermo-Cosmétique/Laboratoires Dermatologiques Avène, France. This journal supplement summarizes highlights this meeting. first review Jean-Marc Lemaitre1 focuses recent advances identification characterization epigenetic alterations senescence, especially senescence-associated secretory phenotype (SASP), important hallmarks targets potential interventions preventing or treating age-related pathologies. Indeed, these shift attitude toward treatment underlying cause emphasis developing prevent delay clear senescent cells mitigate SASP factors combinations healthy lifestyle use senolytics senomorphics, techniques promote tissue rejuvenation stimulation aged stem reprogramming deprogrammed cells. In skin, both chronological associated accumulation increased production metalloproteinases proinflammatory cytokines, dysfunction degradation extracellular matrix lead characteristic signs aging, such thinning epidermis cornified layer, disorganization mechanical fibres dermis, hyperpigmentation. focus Zoe Draelos, Patrick Bogdanowicz Jean-Hilaire Saurat2 is describe molecular mechanisms action clinical effectiveness core group topical products (hyaluronic acid, retinaldehyde, vitamins C E niacinamide), mitigating impact senescence improving function, been shown health. multilevel strategies, combining effective care remodelling different layers topic Kui Young Park Ingrid López Gehrke.3 authors outline commonly used ranging injections fillers biostimulators into deep fat layer hypodermis non-ablative resurfacing lasers dermis subcutaneous tissue, combined cosmeceuticals adjuvants prepare accelerate recovery sustain results. Australia Brazil, where levels exposure high populations predominantly outdoor lifestyles, risk cancer concerns. countries, it essential strategies combat improvements appearance, help occurrence pre-malignant lesions. Greg Goodman Edileia Bagatin4 describes general process characteristics photoaging, highlighting prominent features photo-exposed describing solutions photoaged preventive measures, cosmetic procedures. Finally, SARS-CoV-2 pandemic had many countries access in-clinic aesthetic Analysis since country emerged successive SARS-CoV-2-related lockdowns, summarized final Leona Yip,5 provides valuable insights driving popularity non-surgical procedures, natural organic products. rise wellness movement ideal opportunity encourage adopt holistic includes taking against all exposome. covered during two series articles progress being made field anti-aging. Thus, far searching philosopher's stone gain immortality eternal youth cure we now looking preventative measures wellbeing. As new developed, adapted needs populations, keep pace make better alternative platforms, media, receive safe information skin. We sincerely hope you will enjoy reading issue much enjoyed attending Sydney. thank Emma Pilling, PhD Marielle Romet, (Synergy Pharm-Santé Active Edition) who provided medical writing assistance. Draelos received honoraria Dermo-Cosmétique speaker Entretiens d'Avène, consulting fees SkinBetter Science NuSkin grants Kenvue L'Oreal. Ariadna Ortiz Brugués was employee time foreword. Data sharing applicable article no datasets generated analyzed.

Язык: Английский

Процитировано

0