Molecules,
Год журнала:
2023,
Номер
28(24), С. 8035 - 8035
Опубликована: Дек. 11, 2023
Alzheimer's
disease
(AD)
is
a
neurological
disease,
and
its
signs
symptoms
appear
slowly
over
time.
Although
current
treatments
can
alleviate
symptoms,
they
cannot
prevent
the
from
progressing.
To
accurately
diagnose
treat
it
therefore
necessary
to
establish
effective
methods
for
diagnosis.
Apolipoprotein
E4
(ApoE4),
most
frequent
genetic
risk
factor
AD,
expressed
in
more
than
half
of
patients
with
making
an
attractive
target
AD
therapy.
We
used
molecular
docking
simulations,
classical
mechanics
optimizations,
ab
initio
fragment
orbital
(FMO)
calculations
investigate
specific
interactions
between
ApoE4
naturally
occurring
compounds
found
plant
Moringa
Oleifera.
According
FMO
calculations,
quercetin
had
highest
binding
affinity
among
sixteen
because
hydroxyl
groups
generated
strong
hydrogen
bonds
residues
Trp11,
Asp12,
Arg15,
Asp130.
As
result,
we
proposed
various
derivatives
by
introducing
group
into
studied
their
properties.
The
data
clearly
showed
that
adding
improved
capacity
ApoE4.
Furthermore,
Asp130
were
discovered
be
required
significant
derivatives.
They
higher
our
previously
epicatechin
Accordingly,
results
evaluated
using
method
will
useful
designing
potent
inhibitors
as
candidate
agent
treatment.
Nutrients,
Год журнала:
2024,
Номер
16(6), С. 757 - 757
Опубликована: Март 7, 2024
Isothiocyanates
are
biologically
active
products
resulting
from
the
hydrolysis
of
glucosinolates
predominantly
present
in
cruciferous
vegetables
belonging
to
Brassicaceae
family.
Numerous
studies
have
demonstrated
diverse
bioactivities
various
isothiocyanates,
encompassing
anticarcinogenic,
anti-inflammatory,
and
antioxidative
properties.
Nature
harbors
distinct
isothiocyanate
precursors,
such
as
glucoraphanin
gluconastrin,
each
characterized
by
unique
structures,
physical
properties,
pharmacological
potentials.
This
comprehensive
review
aims
consolidate
current
understanding
Moringa
mainly
4-[(α-L-rhamnosyloxy)
benzyl]
isothiocyanate),
comparing
this
compound
with
other
well-studied
isothiocyanates
sulforaphane
phenyl
ethyl
isothiocyanates.
The
focus
is
directed
toward
elucidating
differences
similarities
efficacy
these
compounds
agents
anticancer,
Phytochemistry Reviews,
Год журнала:
2024,
Номер
23(5), С. 1497 - 1556
Опубликована: Март 18, 2024
Abstract
The
rise
of
air,
water,
and
soil
pollution
poses
a
significant
threat
to
global
health,
leading
widespread
disease
premature
mortality.
Soil
health
is
vital,
ensuring
the
production
safe
food,
but
it
compromised
by
pollutants
such
as
heavy
metals,
pesticides,
plastics,
excessive
fertilization,
resulting
in
depletion
beneficial
microorganisms
subsequently
groundwater
contamination.
Water
bodies
are
polluted
due
contamination
from
industrial
effluents,
domestic
wastewater,
agricultural
runoff,
oil
spillage,
further
intensifying
environmental
pollution.
On
other
hand,
atmospheric
pollution,
characterized
high
emissions
gases,
volatile
compounds,
greenhouse
not
only
impacts
climate
also
serious
risks
human
respiratory
diseases,
cardiovascular
issues,
increased
cancer
risks.
Thus,
strategic
utilization
traditional
plants
emerges
potent
tool
for
restoration
improving
health.
possess
natural
filtering
capabilities,
absorbing
soil,
thus
mitigating
their
adverse
effects.
Through
phytoremediation,
can
be
actively
used
extract
remove
contaminants,
contributing
detoxification
water
quality.
Additionally,
offer
various
benefits.
Moringa
oleifera
or
drumstick
plant
belonging
Moringaceae
family
one
indigenous
with
wide
applications,
that
grown
extreme
arid
conditions.
Since
ancient
times,
this
has
been
treating
skin
infections,
anaemia,
blood
impurities.
This
thrives
diverse
climates
addressing
over
300
different
aliments.
Rich
phytochemicals
bioactive
M.
serve
superfood,
offering
nutritional
values
exhibiting
potential
drug
development
fewer
side
Extensive
research
elucidated
properties
applications
,
however,
in-depth
needed
identify
molecules,
phytochemicals,
protein
compounds
involved,
which
will
aid
understanding
mechanisms
action
plant's
functions.
Although
studies
have
reported
several
individual
attributes
there
no
comprehensive
study
available
its
applications.
review
covers
findings
past
three
decades
provides
detailed
outline
parts,
environmental,
industrial,
food
aspects
documented
date.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 30, 2024
Neuroinflammation
in
response
to
environmental
stressors
is
an
important
common
pathway
a
number
of
neurological
and
psychiatric
disorders.
Responses
immune-mediated
stress
can
lead
epigenetic
changes
the
development
neuropsychiatric
Isothiocyanates
(ITC)
have
shown
promise
combating
oxidative
inflammation
nervous
system
as
well
organ
systems.
While
sulforaphane
from
broccoli
most
widely
studied
ITC
for
biomedical
applications,
their
precursor
glucosinolates
are
found
many
species
cruciferous
other
vegetables
including
moringa.
In
this
review,
we
examine
both
clinical
pre-clinical
studies
on
amelioration
disorders
(neurodevelopmental,
neurodegenerative,
other)
2018
present,
documentation
protocols
several
ongoing
studies.
During
time,
there
been
16
(9
randomized
controlled
trials),
which
reported
effect
autism
spectrum
disorder
schizophrenia.
We
also
review
over
80
preclinical
examining
treatment
brain-related
dysfunctions
The
evidence
date
reveals
great
potential
treating
these
conditions
with
minimal
toxicity.
authors
call
well-designed
trials
further
translation
potent
phytochemicals
into
therapeutic
practice.
Migraine,
a
common
disorder
marked
by
severe
and
repetitive
headaches,
has
been
linked
to
the
involvement
of
NMDA
receptor
(NMDAR),
responsible
for
glutamate
signaling.
Moringa
oleifera
(M.
oleifera),
recognized
its
anti-inflammatory
properties
therapeutic
potential
in
various
conditions,
investigated.
This
study
aims
assess
efficacy
precise
mechanisms
M.
treatment
migraine,
which
evidence
is
limited.
Rats
were
stratified
into
four
distinct
groups.
The
control
group
did
not
undergo
migraine-induction
protocol.
Post-induction,
"sumatriptan"
was
administered
sumatriptan
injections,
"treatment"
received
oral
extract,
"vehicle"
provided
with
solvent
treatment.
Behavioral
evaluations
encompassing
Von
Frey's
hot
plate
assessments,
addition
qPCR
analysis
targeting
Nr2a,
Nr2b,
Bax,
Bcl-2,
Caspase-3,
conducted.
Fery's
tests
revealed
notable
decrease
triggering
pressure
temperature
within
vehicle
when
compared
other
groups
(both
ps
<
0.001).
Nr2a
expression
levels
both
cohorts
exhibited
significantly
higher
values
than
those
observed
(p
0.001,
p
=
0.001)
0.002).
Conversely,
no
substantial
alterations
Nr2b
or
Bcl-2
across
0.404,
0.976).
Notably,
heightened
expressions
Caspase-3
Bax
evident
relative
0.013,
0.010).
extract
appears
mitigate
symptoms
migraine
inhibiting
apoptosis,
suggesting
treatment;
however,
additional
research
investigating
wider
range
pathways
necessary.
Not
applicable.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Апрель 1, 2025
ABSTRACT
The
“miracle
tree,”
Moringa
oleifera
,
has
gained
so
much
attention
because
of
its
spectacular
nutritional
profile
and
potential
health
benefits,
making
it
one
the
candidates
for
functional
food
product
creation.
benefits
M.
are
presented
here
in
this
review
alongside
antioxidant
conformation,
bioactive
constituents,
macro‐
micronutrient
conformation.
is
rapidly
becoming
a
key
effective
component
formulating
healthy
foodstuffs
outstanding
anti‐inflammatory,
antimicrobial,
antidiabetic,
antioxidant,
neuroprotective
activities.
Investigation
into
usage
moringa
products
foods
like
dairy
substitutes,
powders,
supplements,
drinks,
even
snacks
also
part
review.
Notwithstanding
auspicious
there
contests
with
development
such
as
issues
sensory
perception,
active
ingredient
constancy,
budget
constraints.
Maintainable
plant‐based
demand
across
sphere
pushing
novelty
industry.
To
improve
current
scalability
suitability
moringa‐based
foods,
concludes
call
additional
investigation.
