The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 522 - 522
Опубликована: Янв. 8, 2025
The
health-promoting,
preventive,
protective,
and
therapeutic
applications
of
the
natural
compound
sulforaphane
(SF)
produced
from
its
biogenic
precursor
in
broccoli,
glucoraphanin,
are
extremely
well
established.
SF
has
been
subject
thousands
studies
over
125
clinical
trials.
many
mechanisms
action
mammalian
systems
have
extensively
documented.
is
most
potent
naturally
occurring
inducer
Keap1/Nrf2
pathway,
which
well-known
for
upregulation
antioxidant
detoxification
activation
pathways
resulting
inhibition
inflammation.
Much
this
regulation
involves
various
hormonal
axes
body.
However,
influence
on
hormone-mediated
health
conditions
remains
unexplored
recent
scholarly
reviews.
This
review
aims
to
address
gap
by
exploring
these
interactions,
with
a
focus
wellness
issues
specific
both
females
males.
Язык: Английский
Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis
Brain and Development,
Год журнала:
2025,
Номер
47(2), С. 104321 - 104321
Опубликована: Фев. 14, 2025
Язык: Английский
Epigallocatechin -3- gallate mitigates diazinon neurotoxicity via suppression of pro-inflammatory genes and upregulation of antioxidant pathways
BMC Neuroscience,
Год журнала:
2025,
Номер
26(1)
Опубликована: Март 10, 2025
Diazinon
is
a
commonly
used
organophosphate
(OP)
insecticide
especially
in
developing
countries
for
the
control
of
insect
pests,
however,
exposure
to
its
toxic
impact
humans
and
other
non-target
species
remains
an
important
public
health
concern.
The
study
aimed
investigate
effect
epigallocatechin
-3-
gallate
(EGCG),
abundant
green
tea
plants
on
neurobehavioural,
biochemical,
pathological
changes
brain
male
Wistar
rats
following
diazinon
toxicity.
Sixty
adult
were
acclimatized
seven
days
subsequently
randomly
assigned
into
six
treatment
groups
as
follows:
Group
I:
Control
group
(0.2
mL
distilled
water);
II:
at
3
mg/kg
(1%
LD50);
III:
(3
mg/kg)
+
EGCG
(50
mg/kg,
~
2%
IV:
(100
5%
V:
VI:
mg/kg).
All
treatments
administered
orally
once
daily
14
days.
Neurobehavioural
studies,
biomarkers
oxidative
stress,
histology,
immunohistochemistry,
quantitative
polymerase
chain
reaction
(RT
qPCR)
performed.
alone
impaired
recognition
memory,
increased
stress
markers
altered
antioxidant
defense
brain.
It
upregulated
TNF-α
IL-6
genes
repressed
GPx
4
gene
expressions.
was
also
associated
with
GFAP,
Tau,
α-SN
immunoreactivity.
Microscopic
examination
revealed
loss
Purkinje
hippocampal
cells
Co-treatment
however
improved
cognition,
lowered
markers,
status
suppressed
IL-6.
In
conclusion,
findings
from
this
demonstrated
that
offered
protection
against
diazinon-induced
neurotoxicity.
Hence,
natural
sources
such
fruits
vegetables
could
offer
immense
benefits
by
protecting
inflammation
neurodegenerative
disease
conditions.
Clinical
trial
number
Not
applicable.
Язык: Английский
Effects of Sulforaphane on Negative Symptoms and Cognitive Impairments in chronic Schizophrenia patients: A Randomized Double-Blind Trial
Journal of Psychiatric Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1353 - 1353
Опубликована: Апрель 15, 2025
The
brain
accounts
for
about
2%
of
the
body’s
weight,
but
it
consumes
20%
energy
at
rest,
primarily
derived
from
ATP
produced
in
mitochondria.
thus
has
a
high
mitochondrial
density
its
neurons
because
extensive
demands
maintaining
ion
gradients,
neurotransmission,
and
synaptic
activity.
is
also
extremely
susceptible
to
damage
dysregulation
caused
by
inflammation
(neuroinflammation)
oxidative
stress.
Many
systemic
challenges
can
be
mitigated
phytochemical
sulforaphane
(SF),
which
particularly
important
supporting
function.
SF
or
biogenic
precursor
glucoraphanin,
broccoli
seeds
sprouts,
confer
neuroprotective
cognitive
benefits
via
diverse
physiological
biochemical
mechanisms.
able
cross
blood–brain
barrier
as
well
protect
it,
mitigates
consequences
destructive
neuroinflammation.
It
protects
against
neurotoxic
effects
environmental
pollutants,
combats
tissue
cell
wrought
advanced
glycation
end
products
(detoxication),
supports
healthy
glucose
metabolism.
These
are
applicable
individuals
all
ages,
developing
brains
periconception
infancy,
cognitively,
developmentally,
traumatically
challenged
brains,
those
later
life
who
suffering
with
multiple
chronic
conditions
including
Parkinson’s
Alzheimer’s
diseases.
Язык: Английский
The Anti-AGEing and RAGEing Potential of Isothiocyanates
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5986 - 5986
Опубликована: Дек. 19, 2024
Isothiocyanates
(ITCs),
found
in
edible
plants
such
as
cruciferous
vegetables,
are
a
group
of
reactive
organo-sulfur
phytochemicals
produced
by
the
hydrolysis
precursors
known
glucosinolates.
ITCs
have
been
studied
extensively
both
vivo
and
vitro
to
define
their
therapeutic
potential
for
treatment
chronic
health
conditions.
Therapeutically,
they
shown
an
intrinsic
ability
inhibit
oxidative
inflammatory
phenotypes
support
enhanced
health.
This
review
summarizes
current
evidence
supporting
observation
that
antioxidant
anti-inflammatory
activities
temper
pathogenic
effects
metabolites
called
advanced
glycation
end
products
(AGEs).
AGE
exposure
has
significantly
increased
across
lifespan
due
risk
factors
include
dietary
intake,
sedentary
lifestyle,
comorbid
By
contributing
cycle
stress
through
aberrant
activation
transmembrane
receptor
(RAGE),
bioavailability
is
associated
with
disease
onset,
progression,
severity.
debates
molecular
mechanisms
which
may
reduce
RAGE-mediated
pro-oxidant
pro-inflammatory
phenotypes.
Bringing
light
impact
on
biogenesis
stimulate
novel
intervention
strategies
reversing
or
preventing
lifestyle
risk.
Язык: Английский