Reasons for cannabis use during pregnancy and lactation: a qualitative study

Canadian Medical Association Journal, Год журнала: 2021, Номер 193(50), С. E1906 - E1914

Опубликована: Дек. 19, 2021

Background:

Cannabis use among pregnant and lactating people is increasing, despite clinical evidence showing that cannabis may be associated with low birth weight childhood developmental deficits. Our objective was to understand why how these motivations change across perinatal stages.

Methods:

Using qualitative, constructivist grounded theory methodology, we conducted telephone virtual interviews 52 individuals from Canada. We selected participants using maximum variation theoretical sampling. They were eligible if they had been or within the past year decided continue, cease decrease their during period.

Results:

identified 3 categories of reasons pregnancy lactation: sensation-seeking for fun enjoyment; symptom management chronic conditions related pregnancy; coping unpleasant, but nonpathologized, experiences life. Before pregnancy, endorsed in similar proportions, many offering multiple use. During shifted primarily management. lactation, returned resemble those expressed before pregnancy.

Interpretation:

In this study, showed reasons, particularly Reasons changed reproductive The dynamic nature stages speaks participant perception benefits risks, perhaps a desire cast as therapeutic because perceived stigma.

Язык: Английский

---

The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice

EBioMedicine, Год журнала: 2025, Номер unknown, С. 105572 - 105572

Опубликована: Фев. 1, 2025

SummaryBackgroundThe use of cannabis during pregnancy is rising following its widespread legalization. Cannabidiol (CBD) gaining popularity due to the public perception that it safer than psychoactive component Δ9-tetrahydrocannabinol (THC). However, while evidence underpins harm THC and smoke on fetal development, there minimal research safety CBD oral cannabis. The current study aims decipher pregnancy.MethodsUsing a mouse model, we directly compared effects oil exposure (20 mg/kg body weight) from early mid-gestation implantation site remodelling growth. We examined offspring behaviour metabolic activity using both traditional automated cage systems. Lastly, human immune cells assessed how influence angiogenic factor production.FindingsWe observed impaired maternal spiral artery in exposed mice found disrupt cell production. Oral consumption or also resulted significant growth impairment led long-lasting sex-dependent consequences as male exhibited altered aggression females had spatial learning.InterpretationOur results show either developing fetus causes behavioural changes after birth.FundingThe Michael G. DeGroote Centre for Medicinal Cancer Research, Canadian Institutes Health Foundation Innovation.

Язык: Английский

---

Patient Perceptions of Prenatal Cannabis Use and Implications for Clinicians

Obstetrics and Gynecology, Год журнала: 2023, Номер unknown

Опубликована: Авг. 10, 2023

OBJECTIVE: To understand pregnant patients' reasons for prenatal cannabis use and perceptions of safety, desired undesirable health care experiences, information about secondarily to racial differences in these preferences. METHODS: We conducted a qualitative study including 18 semi-structured, race-concordant virtual focus groups with individuals who self-reported at entry large integrated system Northern California from November 2021 December 2021. The included semi-structured questions that were recorded, transcribed, coded by the research team. Thematic analysis was used analyze data. RESULTS: Overall, 53 participants included; 30 self-identified, as White 23 self-identified Black. Participants averaged 30.3 years age (SD 5.2 years) on average 20.9 weeks gestation enrollment; 69.8% reported daily use, 24.5% weekly 5.7% monthly or less entrance care. Although some quit early pregnancy because concerns potential risks, many perceived lack scientific evidence believed safe. Many preferred over-the-counter prescription medications treating mood, morning sickness, pain, sleep. valued open interactions obstetricians acknowledged their motivations they risks through conversations educational materials. Black participants' perspectives generally similar, but few uniquely described bias related use. CONCLUSION: Pregnant patients manage mood medical symptoms, safer than medications. Obstetrician-initiated, patient-centered around advice discontinue during pregnancy, exploration willingness switch medically recommended interventions pregnancy-related symptoms may benefit patients.

Язык: Английский

---

Prenatal tetrahydrocannabinol and cannabidiol exposure produce sex-specific pathophysiological phenotypes in the adolescent prefrontal cortex and hippocampus

Neurobiology of Disease, Год журнала: 2024, Номер 199, С. 106588 - 106588

Опубликована: Июль 1, 2024

Clinical and preclinical evidence has demonstrated an increased risk for neuropsychiatric disorders following prenatal cannabinoid exposure. However, given the phytochemical complexity of cannabis, there is a need to understand how specific components cannabis may contribute these neurodevelopmental risks later in life. To investigate this, rat model exposure was utilized examine impacts constituents (Δ9-tetrahydrocannabinol [THC]; cannabidiol [CBD]) alone combination on future liability male female offspring. Prenatal THC CBD were associated with low birth weight. At adolescence, offspring displayed sex-specific behavioural changes anxiety, temporal order social cognition, sensorimotor gating. These phenotypes sex treatment-specific neuronal gene transcriptional alterations prefrontal cortex, ventral hippocampus, regions where endocannabinoid system implicated affective cognitive development. Electrophysiology RT-qPCR analysis dysregulation balance excitatory inhibitory signalling developmental consequences cannabinoids. findings reveal critical insights into cannabinoids can differentially impact developing fetal brains males females enhance subsequent risk.

Язык: Английский

---

Talking with pregnant women exposed to cannabis use after cannabis legalization: experiences of professionals working in Québec’s Social and Healthcare system

SSM - Qualitative Research in Health, Год журнала: 2025, Номер unknown, С. 100524 - 100524

Опубликована: Янв. 1, 2025

Язык: Английский

---

Factors Associated with Positive Toxicology at Delivery: Insights From the University of Maryland Medical System

Maternal and Child Health Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Язык: Английский

---

Counseling About Cannabis Use During Pregnancy and Lactation: A Qualitative Study of Patient and Clinician Perspectives

Birth, Год журнала: 2024, Номер 51(4), С. 867 - 877

Опубликована: Окт. 11, 2024

ABSTRACT Introduction Legalization in many jurisdictions has increased the prevalence of cannabis use, including during pregnancy and lactation. Accordingly, clinicians providing perinatal infant care are increasingly required to counsel about this topic, even if they do not feel comfortable or prepared for conversation. The aim research was explore how prenatal pregnant lactating women interact with consumption. Methods Using qualitative description, we conducted semi‐structured interviews 75 individuals Canada: 23 who provide lactation care, 52 made consumption decisions and/or Data were analyzed using inductive content analysis. Results Three phases clinical encounter influenced decision‐making consumption: initiation a discussion cannabis, sense‐making, outcome encounter. Patients described similar ideals counseling lactation: open, patient‐centered conversation grounded an informed model benefits, risks, alternatives cannabis. While these values as reflecting real interactions, patients reported that their experience, actual interactions did live up ideals. Conclusion Clinicians people report desiring same things from interaction cannabis: sharing information, identification values, facilitation decision. Both groups endorse nonjudgemental approach explores reasons why patient is considering reflects against available evidence known be safe.

Язык: Английский

---

Perceptions of Cannabis Use and Its Benefits and Risks Among Breastfeeding Mothers

Women s Health Reports, Год журнала: 2024, Номер 5(1), С. 412 - 423

Опубликована: Апрель 1, 2024

Background: Approximately 5% of breastfeeding women report using cannabis. Little is understood about perceived benefits and risks cannabis use; thus, this study aimed to fill gap.

Язык: Английский

---

Perspectives of adolescents and young adults on cannabis use during pregnancy

Addictive Behaviors, Год журнала: 2024, Номер 156, С. 108059 - 108059

Опубликована: Май 7, 2024

Язык: Английский

---

Making informed choices about cannabis use during pregnancy and lactation: A qualitative study of information use

Birth, Год журнала: 2022, Номер 50(3), С. 504 - 512

Опубликована: Июль 18, 2022

Abstract Background Cannabis use during pregnancy and lactation continues to increase as some perceive cannabis be helpful for symptom management coping. As such, pregnant lactating people are faced with challenging decisions, weighing benefits against the potential risks of use. To help clinicians facilitate informed choices, we explored self‐identified information needs who deciding whether or not cannabis. We aimed describe modes sources their information‐seeking satisfaction they found. Methods interviewed 52 in Canada made decision start, stop, continue using lactation. Participants were recruited from advertisements prenatal clinics on social media. utilized an inductive approach analysis focused used decision‐making about use, including process seeking evaluating that information. Results deliberate search information, most commonly Information mainly online material networks. Clinicians described a knowledgeable supportive source Overwhelmingly, participants found insufficient emphasized need more comprehensive trustworthy Conclusions identified distinct unmet associated They desire clear evidence impact how balance perceived harm.

Язык: Английский

---