Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders
Trends in Pharmacological Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Cannabidiol
(CBD),
the
primary
non-intoxicating
compound
in
cannabis,
is
currently
approved
for
treating
rare,
treatment-resistant
seizures.
Recent
preclinical
research
suggests
that
CBD's
multifaceted
mechanisms
of
action
brain,
which
involve
multiple
molecular
targets,
underlie
its
neuroprotective,
anti-inflammatory,
anxiolytic,
and
antipsychotic
effects.
Clinical
trials
are
also
exploring
therapeutic
potential
beyond
current
uses.
This
review
focuses
on
polypharmacological
profile
discusses
latest
clinical
findings
regarding
efficacy
neuropsychiatric
disorders.
Existing
evidence
ability
to
modulate
signaling
pathways
may
benefit
disorders,
we
propose
further
areas
clarify
mechanisms,
address
data
gaps,
refine
indications.
Язык: Английский
Prenatal cannabinoid exposure and the developing brain: evidence of lasting consequences in preclinical rodent models
Neuroscience & Biobehavioral Reviews,
Год журнала:
2025,
Номер
unknown, С. 106207 - 106207
Опубликована: Май 1, 2025
Язык: Английский
Adolescent female rats are resistant to the affective and cognitive impacts of Δ9-tetrahydrocannabinol exposure despite long-lasting molecular and neuronal disturbances in the hippocampal-hypothalamic network
Psychopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Язык: Английский
Sex-specific disruptions in the developmental trajectory of anxiety due to prenatal cannabidiol exposure
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Many
pregnant
women
use
cannabidiol
(CBD)
as
a
natural
remedy
to
alleviate
symptoms
such
nausea,
insomnia,
anxiety,
and
chronic
pain.
As
much
20%
of
pregnancies
in
the
USA
Canada
may
involve
CBD-only
products.
CBD
crosses
placenta
affect
fetal
development,
potentially
leading
neuropsychiatric
conditions
later
life.
Given
limited
understanding
effects
during
pregnancy,
we
adopted
longitudinal
approach
investigate
neurodevelopmental
trajectory
associated
with
prenatal
exposure.
Pregnant
mice
were
administered
3
mg/kg
from
gestational
days
5
18.
At
early
adolescence,
offspring
displayed
sex-specific
behavioral
changes.
Females,
but
not
males,
exhibited
complex
anxiety-like
phenotype
elevated
plus
maze
task.
This
persisted
into
adulthood
open
field
test
was
accompanied
by
altered
reward
responsiveness.
Throughout
post-natal
life,
female
demonstrated
heightened
stretch-attend
postures,
risk-assessment
behavior
reflecting
approach-avoidance
tendencies
anxiety.
Finally,
exposure
increased
repetitive
behaviors
adult
animals
both
sexes,
evidenced
marble
burying
These
results
provide
strong
evidence
disruptions
developmental
trajectories
anxiety
They
challenge
perception
that
is
universally
safe
highlight
vulnerabilities
linked
Язык: Английский