Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model
Epilepsy & Behavior,
Год журнала:
2024,
Номер
151, С. 109618 - 109618
Опубликована: Янв. 6, 2024
Intermittent
fasting
enhances
neural
bioenergetics,
is
neuroprotective,
and
elicits
antioxidant
effects
in
various
animal
models.
There
are
conflicting
findings
on
seizure
protection,
where
intermittent
regimens
often
cause
severe
weight
loss
resembling
starvation
which
unsustainable
long-term.
Therefore,
we
tested
whether
a
less
intensive
regimen
such
as
time-restricted
feeding
(TRF)
may
confer
protection.
Язык: Английский
Preface: Special issue: “Ion channels and genetic epilepsy”
Journal of Neurochemistry,
Год журнала:
2024,
Номер
168(12), С. 3829 - 3830
Опубликована: Май 9, 2024
This
preface
introduces
the
Journal
of
Neurochemistry
Special
Issue
on
Advances
in
Epilepsy
Research.
is
a
devastating
disease
characterized
by
recurrent
seizures.
Despite
addition
numerous
therapeutics
over
last
few
decades
epilepsy
patients
resistant
to
standard
care
treatments
remains
stubbornly
high.
highlights
clear
unmet
clinical
need
and
importance
new
research
into
this
disease.
One
major
advance
two
has
been
recognition
that
genetic
factors
play
significant
role
underlying
pathogenesis
epilepsy.
Much
our
insights
pathogenic
mechanisms
come
from
genes
encode
ion
channels.
In
issue,
there
are
up-to-date
reviews
discussing
caused
variation
HCN
channels,
voltage-dependent
sodium
calcium
GABA
Язык: Английский
Optimizing ketogenic diet therapy for childhood epilepsy: Identifying key factors for seizure control and psychomotor enhancement
Epilepsia,
Год журнала:
2024,
Номер
65(10), С. 2959 - 2972
Опубликована: Авг. 27, 2024
Abstract
Objective
To
identify
key
factors
influencing
the
therapeutic
efficacy
of
ketogenic
diet
(KD)
for
children
with
drug‐resistant
epilepsy
and
elucidate
their
interconnected
relationships
to
optimize
clinical
practice.
Methods
Participants
were
selected
from
receiving
KD
treatment
at
West
Second
University
Hospital
Sichuan
September
2015
October
2023.
Clinical
pre‐KD
post‐KD
(at
third
month)
analyzed
systematically
using
an
analytical
framework.
Descriptive
analyses,
univariate
multivariate
regression
analyses
performed
entire
cohort
subgroups
genetic
non‐genetic
(i.e.,
structural
unknown)
etiologies.
Thereby,
most
significant
predictors
identified
each
relevant
dependent
variable.
Path
analysis
diagrams
used
visual
representation.
Results
Of
156
patients,
etiology
was
prevalent
(38.5%).
In
subgroup,
channelopathies
predicted
lower
baseline
seizure
frequency
increased
chance
freedom
KD.
Frequent
seizures
complex
history
anti‐seizure
medications
(ASMs)
severe
psychomotor
abnormalities.
Younger
age
initiation
benefited
improvement.
likelihood
post‐KD.
Concurrent
use
multiple
ASMs
helped
achieve
≥50%
reduction.
Boys
more
likely
experience
A
correlation
found
between
reduction
improvement
in
both
subgroups.
Delayed
(longer
duration
start)
related
a
greater
number
used,
infrequent
seizures,
older
onset.
addition,
patients
had
delayed
Significance
Children
display
pronounced
characteristics
epileptic
encephalopathy.
Early
intervention
is
crucial
channelopathies,
notably
SCN1A
variants.
For
other
cases,
alongside
diverse
may
improve
control
developmental
outcomes.
However,
patient
population
benefiting
early
tends
start
later,
urging
re‐evaluation
decision‐making
paradigms.
Язык: Английский
Retinal neurochemistry; metabolic effects of epilepsy-linked genes; LAMP1 protein
The Transmitter,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Scientists
are
increasingly
proposing
measures
of
retinal
neurochemistry
as
biomarkers
clinical
conditions,
including
autism,
attention-deficit/hyperactivity
disorder
and
schizophrenia.Frontiers
in
Neuroscience
Autistic
children
have
lower
blood
levels
the
protein
ADAM8
than
non-autistic
do,
according
to
a
small
study.Neuropsychiatric
Disease
Treatment
toddlers
show
altered
neural
responses
human
speech.Journal
Online
surveys
susceptible
fraudulent
responses,
but
there
ways
identify
prevent
such
fakes.Spectrum
reported
on
various
efforts
flag
online
survey
fraud
last
week.PLOS
Global
Public
Health
people
better
at
interpreting
behavior
an
autistic
person
workplace
setting.Autism
Adulthood
The
National
Association
for
Biomedical
Research
is
challenging
conservation
group's
determination
that
long-tailed
macaques,
primate
commonly
used
research,
endangered.Science
Variants
genes
-such
SCN1A
KCNA1
-that
affect
ion
channels
cause
epilepsy
appear
bring
about
metabolic
changes
contribute
seizure
activity,
review.Journal
Neurochemistry
Non-cancer
therapies
genetic
conditions
take
average
25
years
develop
-from
identification
target
government
approval
treatment.Nature
Frequency
change:
(top
row)
(bottom
different
EEG
activity
response
natural
speech.
Язык: Английский
Dynamic Foraging Behavior Performance Is Not Affected byScn2aHaploinsufficiency
eNeuro,
Год журнала:
2023,
Номер
10(12), С. ENEURO.0367 - 23.2023
Опубликована: Дек. 1, 2023
Dysfunction
in
the
gene
SCN2A,
which
encodes
voltage-gated
sodium
channel
Nav1.2,
is
strongly
associated
with
neurodevelopmental
disorders
including
autism
spectrum
disorder
and
intellectual
disability
(ASD/ID).
This
dysfunction
typically
manifests
these
as
a
haploinsufficiency,
where
loss
of
one
copy
cannot
be
compensated
for
by
other
allele.
Scn2a
haploinsufficiency
affects
range
cells
circuits
across
brain,
associative
neocortical
that
are
important
cognitive
flexibility
decision-making
behaviors.
Here,
we
tested
whether
has
any
effect
on
dynamic
foraging
task
engages
such
circuits.
+/-
mice
wild-type
(WT)
littermates
were
trained
choice
behavior
probability
reward
between
two
options
varied
dynamically
trials
location
high
underwent
uncued
reversals.
Despite
impairments
Scn2a-related
neuronal
excitability,
found
both
male
female
performed
tasks
well
littermates,
no
behavioral
difference
genotypes
learning
or
performance
parameters.
Varying
number
reversals
probabilities
receiving
did
not
result
an
observable
difference,
either.
These
data
suggest
that,
despite
heterozygous
Scn2a,
can
perform
relatively
complex
make
use
higher-order
Язык: Английский