Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12155 - 12155

Опубликована: Ноя. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Язык: Английский

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Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5377 - 5377

Опубликована: Май 15, 2024

In recent years, there has been a growing interest in the concept of “gut–brain axis”. addition to well-studied diseases associated with an imbalance gut microbiota, such as cancer, chronic inflammation, and cardiovascular diseases, research is now exploring potential role microbial dysbiosis onset development brain-related diseases. When function intestinal barrier altered by dysbiosis, aberrant immune system response interacts nervous system, leading state “neuroinflammation”. The microbiota–brain axis mediated inflammatory immunological mechanisms, neurotransmitters, neuroendocrine pathways. This narrative review aims illustrate molecular basis neuroinflammation elaborate on gut–brain virtue analyzing various metabolites produced microbiome how they might impact system. Additionally, current will highlight sex influences these mechanisms. fact, hormones brain–gut microbiota at different levels, central enteric one, enteroendocrine cells. A deeper understanding human health disease crucial guide diagnoses, treatments, preventive interventions.

Язык: Английский

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Design, synthesis and biological evaluation of N-substituted nipecotamide derivatives as multifunctional agents for epilepsy treatment

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117613 - 117613

Опубликована: Апрель 1, 2025

Язык: Английский

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Update on Inherited Disorders of GABA Metabolism

European Journal of Paediatric Neurology, Год журнала: 2025, Номер 56, С. 10 - 16

Опубликована: Апрель 13, 2025

Язык: Английский

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Insights of Neuroreceptor Endocytosis and Signaling in Health and Disease

˜The œReceptors, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 1, 2025

Язык: Английский

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GABA, epigallocatechin gallate, tea, and the gut-brain axis

Neurochemistry International, Год журнала: 2024, Номер unknown, С. 105860 - 105860

Опубликована: Сен. 1, 2024

Язык: Английский

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