Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 19, 2024
The gut microbiome (GM) has been implicated in cancer pathogenesis and treatment, including head neck cancers (HNC). However, the specific microbial compositions influencing HNC underlying mechanisms remain largely unknown.
Язык: Английский
Nutrients, Год журнала: 2025, Номер 17(5), С. 922 - 922
Опубликована: Март 6, 2025
Background: Alzheimer's disease (AD) represents one of the major challenges modern medicine, with a growing impact on public health and healthcare systems. In recent years, dietary supplements use has been subject increasing interest as complementary strategy for prevention treatment disease. Materials Methods: A Review reviews was conducted following PRISMA guidelines REAPPRAISED checklist to evaluate efficacy safety supplement in AD. The search, performed across scientific databases, identified 54 relevant articles, including 53 mini-review, after applying specific inclusion criteria removing duplicates. Results: body evidence suggests that some may help reduce cognitive decline, inflammation, target mechanisms behind However, many these are still under investigation, mixed results highlighting need high-quality research. key challenge is lack data optimal dosages, administration duration, long-term safety, which limits clinical guidelines. Some studies have reported positive effects from regimens, such curcumin (800 mg/day), omega-3 fatty acids (2 g/day), resveratrol (600 mg/day). Other supplements, like phosphatidylserine (300 multinutrient formulations, probiotics, vitamin E (2000 IU/day), melatonin (3-10 also show benefits, though study variability makes conclusions uncertain. Conclusions: While certain potential mitigating decline AD, inconsistent findings gaps dosage highlight rigorous, large-scale trials. Future research should focus personalized, multimodal strategies integrating targeted supplementation, patterns, microbiota-gut-brain interactions enhanced neuroprotection.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1716 - 1716
Опубликована: Авг. 1, 2024
The term 'inflammaging' has been coined to describe the chronic state of inflammation derived from ongoing cycles tissue damage and subsequent immune responses. This inflammatory status contributes decline organs physiological functions, accelerates aging process, increases risk age-related illnesses death. During aging, gut microbiota (GM) undergoes significant changes, including a decreased diversity species, in beneficial bacteria, rise proinflammatory ones, resulting persistent low-grade inflammation. Moreover, environmental factors, such as diet medications, contribute changes GM function, preventing or promoting inflammaging. narrative review aims clarify underlying mechanisms inflammaging specifically investigate influence several factors on these mechanisms, while also exploring potential differences related sex. lifestyle pharmacological interventions will be suggested promote healthy aging.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9573 - 9573
Опубликована: Сен. 4, 2024
Alzheimer’s disease (AD) represents a significant global health challenge and affects approximately 50 million people worldwide. This overview of published reviews provides comprehensive understanding the intricate correlations between AD body composition, focusing particularly on obesity. We used systematic approach to collect analyze relevant topic obesity disease. A search electronic databases, including PubMed, MEDLINE, Google Scholar, was conducted. searched keywords such as “Alzheimer’s disease”, “body composition”, “lean mass”, “bone “fat mass”. considered only written within past 5 years in English. Fifty-six were identified that shed light multiple connections composition. The review involves several aspects, impact lean mass, bone endocrinological factors related obesity, well inflammation, neuroinflammation, molecular/genetic factors. findings highlight complex interplay these elements development AD, underscoring need for holistic approaches reduce risk explore innovative strategies diagnosis, prevention, treatment.
Язык: Английский
Процитировано
1
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 19, 2024
The gut microbiome (GM) has been implicated in cancer pathogenesis and treatment, including head neck cancers (HNC). However, the specific microbial compositions influencing HNC underlying mechanisms remain largely unknown.
Язык: Английский
Процитировано
0