Various
factors
have
been
attributed
to
the
inconsistent
reproducibility
of
human
oxytocin
research
in
cognitive
and
behavioral
sciences.
These
include
small
sample
sizes,
a
lack
pre-registered
studies,
absence
overarching
theoretical
frameworks
that
can
account
for
oxytocin’s
effects
over
broad
range
contexts.
While
there
efforts
remedy
these
issues,
has
very
little
systematic
scrutiny
role
auxiliary
assumptions,
which
are
claims
not
central
testing
hypothesis
but
nonetheless
critical
theories.
For
instance,
increases
salience
social
cues
is
predicated
on
assumption
intranasally
administered
levels
brain.
Without
robust
it
unclear
whether
failure
due
an
incorrect
or
poorly
supported
assumptions.
Consequently,
assumptions
be
blamed
failure,
thereby
safeguarding
theories
from
falsification.
In
this
article,
I
will
evaluate
body
evidence
key
terms
theory,
experimental
design,
statistical
inference,
highlight
require
stronger
evidence.
Strong
leave
hypotheses
vulnerable
falsification,
improve
consequently
advance
our
understanding
cognition
behavior.
Advances in Methods and Practices in Psychological Science,
Год журнала:
2023,
Номер
6(1)
Опубликована: Янв. 1, 2023
Meta-analysis
is
a
popular
approach
in
the
psychological
sciences
for
synthesizing
data
across
studies.
However,
credibility
of
meta-analysis
outcomes
depends
on
evidential
value
studies
included
body
evidence
used
synthesis.
One
important
consideration
determining
study’s
statistical
power
design/statistical
test
combination
detecting
hypothetical
effect
sizes
interest.
Studies
with
design/test
that
cannot
reliably
detect
wide
range
are
more
susceptible
to
questionable
research
practices
and
exaggerated
sizes.
Therefore,
combinations
meta-analyses
can
help
researchers
make
decisions
regarding
confidence
evidence.
Because
one
true
population
size
unknown
when
hypothesis
testing,
an
alternative
determine
This
tutorial
introduces
metameta
R
package
web
app,
which
facilitates
straightforward
calculation
visualization
study-level
Readers
will
be
shown
how
reanalyze
using
information
typically
presented
forest
plots
or
tables
integrate
reporting
novel
meta-analyses.
A
step-by-step
companion
screencast
video
also
provided
assist
readers
package.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2022,
Номер
377(1858)
Опубликована: Июль 11, 2022
In
this
paper,
we
analyse
the
claim
that
oxytocin
is
a
'social
neuropeptide'.
This
originated
from
evidence
was
instrumental
in
initiation
of
maternal
behaviour
and
it
extended
to
become
has
key
role
promoting
social
interactions
between
individuals.
We
begin
by
considering
structure
scientific
literature
on
topic,
identifying
closely
interconnected
clusters
papers
particular
themes.
then
four
types
as
generated
these
clusters:
(i)
mechanistic
studies
animal
models,
designed
understand
pathways
involved
behavioural
effects
centrally
administered
oxytocin;
(ii)
observational
indicating
an
association
signalling
behaviour;
(iii)
intervention
studies,
mainly
involving
intranasal
administration;
(iv)
translational
patients
with
disorders
behaviour.
critically
most
highly
cited
each
segment
evidence;
conclude
that,
if
represent
best
evidence,
for
weak.
article
part
theme
issue
'Interplays
other
neuromodulators
shaping
complex
behaviours'.
The Journal of Headache and Pain,
Год журнала:
2023,
Номер
24(1)
Опубликована: Март 26, 2023
Abstract
Migraine
is
a
severe
neurovascular
disorder
of
which
the
pathophysiology
not
yet
fully
understood.
Besides
role
inflammatory
mediators
that
interact
with
trigeminovascular
system,
cyclic
fluctuations
in
sex
steroid
hormones
are
involved
dimorphism
migraine
attacks.
In
addition,
pituitary-derived
hormone
prolactin
and
hypothalamic
neuropeptide
oxytocin
have
been
reported
to
play
modulating
contribute
its
sex-dependent
differences.
The
current
narrative
review
explores
relationship
between
these
two
migraine.
We
describe
physiological
oxytocin,
pain,
potential
therapies
targeting
or
their
receptors.
summary,
nociception
opposite
ways.
Both
operate
at
peripheral
central
levels,
however,
has
pronociceptive
effect,
while
appears
an
antinociceptive
effect.
Therefore,
treatment
should
aim
block
effects
using
receptor
antagonists
monoclonal
antibodies
specifically
acting
migraine-pain
related
structures.
This
action
be
local
order
avoid
decrease
levels
throughout
body
associated
adverse
effects.
contrast,
enhance
signalling
effects,
for
example
intranasal
administration
possibly
other
agonists.
Interestingly,
co-localized
estrogen
receptors
as
well
calcitonin
gene-related
peptide
receptor,
providing
positive
perspective
on
possibilities
adequate
pharmacological
nociceptive
pathways.
Nevertheless,
many
questions
remain
answered.
More
particularly,
there
insufficient
data
men
correct
dosing
according
differences,
hormonal
changes
comorbidities.
above
remains
major
challenge
future
development.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
163, С. 105765 - 105765
Опубликована: Июнь 15, 2024
The
neuropeptide
oxytocin
has
historically
been
associated
with
reproduction
and
maternal
behavior.
However,
more
recent
research
uncovered
that
a
much
wider
range
of
roles
in
physiology
Despite
the
excitement
surrounding
potential
therapeutical
applications
intranasally
administered
oxytocin,
results
these
intervention
studies
have
inconsistent.
Various
reasons
for
mixed
proposed,
which
tend
to
focus
on
methodological
issues,
such
as
study
design.
While
issues
are
certainly
important,
emerging
evidence
suggests
interaction
between
sex
hormones
may
also
account
varied
findings.
To
better
understand
purpose
function
hormones,
estrogens,
progesterone,
testosterone,
we
conducted
comprehensive
thematic
review
via
four
perspectives:
evolutionary,
developmental,
mechanistic,
survival.
Altogether,
this
synergistic
approach
highlights
critical
hormone
activity
accomplishing
diverse
modulation
release
receptor
activity,
is
likely
contribute
heterogeneity
outcomes
after
administration.
Animal Models and Experimental Medicine,
Год журнала:
2024,
Номер
7(2), С. 189 - 193
Опубликована: Март 26, 2024
Abstract
The
current
restrictive
criteria
for
gasotransmitters
exclude
oxygen
(O
2
)
as
a
gasotransmitter
in
vertebrates.
In
this
manuscript,
I
propose
revision
of
to
include
O
per
se
signaling
molecule
and
'essential
gasotransmitter'
This
would
enable
us
search
protein‐based
‐binding
sensors
(gasoreceptors)
all
cells
the
brain
or
other
tissues
rather
than
specialized
such
carotid
body
gills.
If
microorganisms
have
gasoreceptors
DosP
FixL
FNR
with
diverse
domains,
then
eukaryotic
must
also
gasoreceptors.
Just
there
are
receptor(s)
nitric
oxide
(GUCY1A,
GUCY1B,
CLOCK,
NR1D2)
tissues,
it
is
reasonable
consider
that
receptors
well.
mammals,
be
acting
gaseous
via
androglobin
very
likely
mediate
acute
sensing
.
Accepting
an
essential
will
not
only
but
nonessential
hydrogen
sulfide,
ammonia,
methane,
ethylene.
It
allow
investigate
role
environment‐derived
metal
ions
gas
(or
solute)
within
between
organisms.
Finally,
accepting
open
up
field
gasocrinology.
Aging Brain,
Год журнала:
2022,
Номер
2, С. 100028 - 100028
Опубликована: Янв. 1, 2022
Older
adults
have
been
neglected
in
biobehavioral
oxytocin
research.
Emerging
research
indicates
that
signaling
activity
fluctuates
over
the
lifespan,
which
suggests
results
from
studies
investigating
youth
and
young
cannot
be
easily
generalized
to
older
adults.
The
recruitment
of
a
wider
age
range
participants
using
variety
tools
is
required
uncover
role
system
lifespan
may
reveal
novel
treatment
target
candidates
adults,
beyond
social
cognition
behavior.
Meta-analysis
is
a
popular
approach
in
the
psychological
sciences
for
synthesizing
data
across
studies.
However,
credibility
of
meta-analysis
outcomes
depends
on
evidential
value
studies
included
body
evidence
used
synthesis.
One
important
consideration
determining
study’s
statistical
power
design
and
test
combination
detecting
hypothetical
effect
sizes
interest.
Studies
with
design/test
that
cannot
reliably
detect
wide
range
are
more
susceptible
to
questionable
research
practices
exaggerated
sizes.
Therefore,
combinations
meta-analyses
can
help
researchers
make
decisions
regarding
confidence
evidence.
As
one
true
population
size
unknown
when
hypothesis
testing,
an
alternative
determine
This
tutorial
introduces
metameta
R
package
web
app,
which
facilitates
straightforward
calculation
visualization
study-level
Readers
will
be
shown
how
re-analyze
using
information
typically
presented
forest
plots
or
tables
integrate
reporting
novel
meta-analyses.
A
step-by-step
companion
screencast
video
also
provided
assist
readers
package.
