Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Nature Reviews Neurology, Год журнала: 2022, Номер 18(11), С. 643 - 660

Опубликована: Сен. 30, 2022

Язык: Английский

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The Mediterranean Diet: An Update of the Clinical Trials

Nutrients, Год журнала: 2022, Номер 14(14), С. 2956 - 2956

Опубликована: Июль 19, 2022

The Mediterranean Diet (MedDiet) is a term used to identify dietary pattern originating from the unique multi-millennial interplay between natural food resources and eating practices of people living in basin. Scientific evidence has described healthy properties MedDiet its beneficial role several pathological conditions. Nevertheless, current socio-economic trends have moved away this lifestyle. Thus, clinical biological supporting benefits needed overcome these limitations. Clinical nutrition research examines effects interventions on or health-related outcomes determined study population. produced by studies useful for guidance public health messaging. We provided an update trials registered database clinicaltrials.gov evaluating specific diseases. Our findings revealed increased number last decade found that most disease-related focused cardiovascular diseases, metabolic cancer. majority MedDiet’s could be primarily related anti-inflammatory anti-oxidant as well effectiveness controlling waist circumference obesity. Moreover, strict long-lasting adherence components (e.g., olive oil polyphenols) seem emerge insights interventional improvements. These present further into how it strengthen overall health.

Язык: Английский

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Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(5), С. 2542 - 2542

Опубликована: Фев. 25, 2022

Diet might affect male reproductive potential, but the biochemical mechanisms involved in modulation of sperm quality remain poorly understood. While a Western diet is considered risk factor for infertility, Mediterranean seems to protect against infertility; moreover, role vegetarian habitus preservation controversial. The aim this review analyze molecular effects single nutrients on quality, focusing their involvement related bioenergetics. It appears that diets rich saturated fatty acids (SFA) and low polyunsaturated (PUFA) negatively whereas unsaturated supplementation ameliorates quality. In fact, administration PUFA, especially omega-3 determined an increase mitochondrial energetic metabolism reduction oxidative damage. Carbohydrates proteins are also nutritional modulators stress testosterone levels, which strictly linked function, key element Moreover, many dietary natural polyphenols differentially (positively or negatively) depending concentration. We believe understanding responsible will lead more targeted effective therapeutics infertility.

Язык: Английский

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Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 20(9), С. 582 - 596

Опубликована: Июнь 2, 2023

Язык: Английский

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Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Antioxidants, Год журнала: 2022, Номер 11(2), С. 232 - 232

Опубликована: Янв. 26, 2022

Lycopene is a bioactive red pigment found in plants, especially fruits and vegetables, including tomato, pink guava, papaya, grapefruit, watermelon. Several research reports have advocated its positive impact on human health physiology. For humans, lycopene an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress downstream complications include one major concerns worldwide. In recent years, counter strategies attracted biomedical order manage emerging issues. has been reported directly interact with ROS, which can help prevent chronic diseases, diabetes neurodegenerative cardiovascular diseases. this context, present review article was written provide accumulative account protective ameliorative effects coronary artery disease (CAD) hypertension, are leading causes death potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting angiotensin-converting enzyme regulating nitrous oxide bioavailability. plays important role lowering LDL (low-density lipoproteins) improving HDL (high-density levels minimize atherosclerosis, protects onset hypertension. Various studies exhibited combating competence treatment these Owing all antioxidant, anti-diabetic, anti-hypertensive properties, provides potential nutraceutical curing ability against

Язык: Английский

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Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Nutrients, Год журнала: 2024, Номер 16(6), С. 800 - 800

Опубликована: Март 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Язык: Английский

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Animal- and Plant-Based Protein Sources: A Scoping Review of Human Health Outcomes and Environmental Impact

Nutrients, Год журнала: 2022, Номер 14(23), С. 5115 - 5115

Опубликована: Дек. 1, 2022

Dietary proteins are indispensable to human nutrition. In addition their tissue-building function, they affect body composition and regulate various metabolic pathways, as well satiety immune system activity. Protein use can be examined from a quantitative or qualitative viewpoint. this scoping review, we compare animal- plant-based protein sources in terms of effects on health the environment. We conclude that consumption vegetable is associated with better outcomes overall (namely, cardiovascular system) than animal-based product use. The healthier dovetail lower environmental impact, which must considered when designing an optimal diet. Indeed, planet cannot disjointed being. Future research will clarify mechanisms action underlying compared animal sources, fostering agronomic practices influencing public direction benefit both its inhabitants.

Язык: Английский

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The Effects of the Mediterranean Diet on Health and Gut Microbiota

Nutrients, Год журнала: 2023, Номер 15(9), С. 2150 - 2150

Опубликована: Апрель 29, 2023

The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions vegetables, fruit, cereals, olive oil. Although there are challenges with isolating the MD from typical lifestyle culture (including prolonged ‘social’ meals siestas), much evidence supports health benefits that include improved longevity, reduced metabolic risk Diabetes Mellitus, obesity, Metabolic Syndrome, malignancy cardiovascular disease, cognitive function. also associated characteristic modifications to gut microbiota, mediated through its constituent parts (primarily dietary fibres, extra virgin oil, polyunsaturated fatty acids [including ω-3]). These enhanced growth species produce short-chain (butyrate), such as Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides, Faecalibacterium prausnitzii species, Firmicutes Blautia species. Such changes in microbiota known be favourably inflammatory oxidative status, propensity for overall health. A key challenge future explore extent which by microbiota. confers both environmental benefits. Adoption should perhaps encouraged facilitated more generally not just restricted populations regions. However, this approach limited perennial availability some non-Mediterranean regions, intolerability a high-fibre diet people, potential cultural disconnects juxtapose traditional Western) diets MD.

Язык: Английский

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Mediterranean Diet on Sleep: A Health Alliance

Nutrients, Год журнала: 2022, Номер 14(14), С. 2998 - 2998

Опубликована: Июль 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Язык: Английский

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Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9577 - 9577

Опубликована: Май 31, 2023

The human gut microbiome contains the largest number of bacteria in body and has potential to greatly influence metabolism, not only locally but also systemically. There is an established link between a healthy, balanced, diverse overall health. When becomes unbalanced (dysbiosis) through dietary changes, medication use, lifestyle choices, environmental factors, ageing, this profound effect on our health linked many diseases, including metabolic inflammatory neurological diseases. While humans largely association dysbiosis with disease, animal models, causative can be demonstrated. brain particularly important maintaining health, strong neurodegenerative neurodevelopmental This suggests that microbiota composition used make early diagnosis diseases modifying microbiome-gut-brain axis might present therapeutic target for have proved intractable, aim altering trajectory such as Alzheimer's Parkinson's multiple sclerosis, autism spectrum disorder, attention-deficit hyperactivity among others. other potentially reversible migraine, post-operative cognitive dysfunction, long COVID, which considered models therapy disease. role traditional methods microbiome, well newer, more novel treatments faecal transplants photobiomodulation, are discussed.

Язык: Английский

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