Periodontitis Exacerbates Colorectal Cancer by Altering Gut Microbiota–Derived Metabolomics in Mice
Journal of Periodontal Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
ABSTRACT
Aim
The
correlation
between
periodontitis
and
colorectal
cancer
(CRC)
has
drawn
widespread
attention.
However,
how
affects
CRC
progression
remains
unclear.
Methods
C57BL/6
mice
were
used
to
establish
experimental
model.
Histological
alterations
of
periodontium
colon
observed
by
hematoxylin
eosin
staining.
Micro‐computed
tomography
(micro‐CT)
was
applied
evaluate
alveolar
bone
loss
(ABL).
Tumor
growth
detected
immunofluorescence.
Gut
bacteria
analyzed
using
16S
rRNA
sequencing.
Gas
chromatography–mass
spectrometry
(GC–MS)
performed
observe
the
gut
microbial
metabolites.
detection
associated
pathways
carried
out
quantitative
real‐time
PCR
(qRT‐PCR).
Results
Experimental
significantly
induced
increases
in
tumor
number
with
CRC.
Double
immunofluorescence
for
Ki67
β‐catenin,
as
well
Cyclin
D1
indicated
that
observably
promoted
growth.
sequencing
untargeted
metabolomics
analysis
displayed
altered
community
metabolite
profiles
mice.
Notably,
we
found
dramatically
increased
level
three
oncometabolites
(serotonin,
adenosine,
spermine)
Conclusion
Alterations
metabolites
might
be
relevant
deteriorating
Язык: Английский
Streptococcus anginosus: the potential role in the progression of gastric cancer
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2025,
Номер
151(4)
Опубликована: Апрель 19, 2025
Gastric
cancer
(GC)
is
among
the
most
common
and
aggressive
malignancies
worldwide,
characterized
by
a
poor
prognosis.
Research
on
its
pathogenesis
progression
continues
to
evolve.
Streptococcus
anginosus
(S.
anginosus,
SA)
Gram-positive
coccus
commonly
found
in
oral
cavity
upper
respiratory
tract,
serving
as
commensal
bacterium
oral,
gastrointestinal,
genitourinary
tracts.
It
frequently
associated
with
abscess
formation
various
organs
tissues,
well
other
purulent
infections.
In
recent
years,
S.
has
gained
increasing
attention
for
role
GC
progression,
potentially
leading
chronic
gastric
inflammation
precancerous
lesions,
ultimately
promoting
development
of
GC.
Emerging
evidence
indicates
strong
association
between
malignant
unfavorable
prognosis
This
review
summarizes
underlying
mechanisms
proposes
that
plays
pivotal
initiation
underscoring
potential
therapeutic
significance.
Язык: Английский
Cardiovascular Disease Detection in Dental Settings—Development and External Validation of a Nomogram (PerioCARD)
Journal of Periodontal Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 26, 2025
ABSTRACT
Aim
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
mortality
and
morbidity
worldwide.
Since
many
people
visit
their
dentists
regularly,
assessing
CVD
in
dental
settings
offers
valuable
opportunities
for
its
early
detection.
This
study
aims
to
identify
easily
accessible
indicators
that
are
associated
with
adults
develop
nomogram,
providing
practical
tool
integrate
case
detection
into
routine
care.
Methods
Demographic
(age
sex),
self‐reported
history
(smoking,
high
cholesterol,
diabetes,
use
hypertension
medications),
periodontal
data
from
the
2009
2010
National
Health
Nutrition
Examination
Survey
(NHANES)
were
utilized
as
candidate
predictors
model
training,
targeting
reference
standard.
Multivariable
logistic
regression
models
assessed
using
receiver
operating
characteristic
analysis
calibration
curves.
The
nomogram
was
internally
validated
bootstrapping
externally
(NHANES
2011–2012;
2013–2014)
discrimination
calibration.
Results
Two
thousand
eight
hundred
ninety
participants
selected
training
7416
external
validation.
final
model,
PerioCARD
(Periodontal‐based
Assessment
Recognition
Disease),
included
age,
sex,
smoking,
hypertensive
medications,
status.
achieved
an
area
under
curve
(AUC)
0.82
(95%
CI:
0.80–0.84)
identifying
CVD,
precision–recall
(AUPRC)
0.38
0.34–0.43).
validation
set
had
AUC
0.81–0.84)
AUPRC
0.32
0.30–0.36),
good
clinical
net
benefits
decision
analysis.
Conclusion
developed
parameters
chair.
may
have
implications
rapid
individuals
by
professionals.
Язык: Английский
Oral Microbiota and the Risk of Gastrointestinal Cancers—A Narrative Literature Review
Pathogens,
Год журнала:
2024,
Номер
13(9), С. 819 - 819
Опубликована: Сен. 23, 2024
The
human
body
is
colonized
by
trillions
of
microorganisms
in
a
symbiotic
relationship.
oral
cavity
represents
one
the
most
abundant
microbial
habitats
our
body.
Advances
sequencing
techniques
provide
more
detailed
understanding
microbiota
and
how
imbalances
between
bacteria,
phenomenon
dysbiosis,
can
affect
not
only
development
dental
caries
or
inflammation
within
but
also
systemic
diseases
cancers
distant
locations.
This
narrative
review
evaluates
relationship
its
impact
on
gastrointestinal
cancers.
Using
keywords
“oral
‘AND’
cancers”,
PubMed
Web
Science
Scopus
databases
were
searched
for
articles
published
2014
2024.
Based
review,
oral,
esophageal,
gastric,
colorectal,
hepatocellular,
pancreatic
was
described.
Potential
oncogenic
mechanisms
exploited
such
as
production
pro-inflammatory
cytokines,
induction
abnormal
immune
responses,
disruption
cell
metabolic
pathways
assessed.
Further
research
thorough
tract
may
play
key
role
their
prevention,
diagnosis,
treatment
future.
Язык: Английский
Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis
Journal of Gastroenterology and Hepatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
ABSTRACT
Background
Cholecystectomy
(CCE)
can
affect
the
enterohepatic
circulation
of
bile
acids
and
result
in
gut
microbiome
changes.
This
systematic
review
aimed
to
clarify
effect
CCE
on
composition
its
clinical
impact.
Method
A
search
was
conducted
PubMed,
Web
Science,
Scopus,
combining
keywords
such
as
“cholecystectomy”
or
“post‐cholecystectomy”
with
“gut
microbiome,”
“stool
dysbiosis.”
Data
were
extracted
synthesized
using
narrative
review.
Study
quality
assessed
Newcastle‐Ottawa
scale.
Results
total
1373
articles
screened
14
studies
selected.
Significant
but
inconsistent
changes
reported.
Changes
observed
alpha
beta
diversity.
At
phylum
level,
an
increase
Bacteroides
Ascomycota,
decrease
Firmicutes,
Actinomycetes,
Basidiomycota,
both
Fusobacteria
genus
Prevotella
a
Faecalibacterium
In
post‐CCE
diarrhea,
decreased
diversity,
F/B
ratio,
,
Phocaeicola
vulgatus
copri
noted.
For
syndrome,
higher
abundance
Proteobacteria
Firmicutes/Bacteroides
(F/B)
ratio
relative
Bifidobacterium
longum
subsp
.
from
controls
without
colonic
neoplasia
neoplasia,
increased
Candida
glabrata
controls,
Conclusion
Patients
who
underwent
had
significant
dysbiosis.
However,
current
could
not
detailed
microbial
structural
functional
associated
CCE.
Язык: Английский