Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis DOI Creative Commons
Tiing Leong Ang, Seok Hwee Koo, Daphne Ang

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

ABSTRACT Background Cholecystectomy (CCE) can affect the enterohepatic circulation of bile acids and result in gut microbiome changes. This systematic review aimed to clarify effect CCE on composition its clinical impact. Method A search was conducted PubMed, Web Science, Scopus, combining keywords such as “cholecystectomy” or “post‐cholecystectomy” with “gut microbiome,” “stool dysbiosis.” Data were extracted synthesized using narrative review. Study quality assessed Newcastle‐Ottawa scale. Results total 1373 articles screened 14 studies selected. Significant but inconsistent changes reported. Changes observed alpha beta diversity. At phylum level, an increase Bacteroides Ascomycota, decrease Firmicutes, Actinomycetes, Basidiomycota, both Fusobacteria genus Prevotella a Faecalibacterium In post‐CCE diarrhea, decreased diversity, F/B ratio, , Phocaeicola vulgatus copri noted. For syndrome, higher abundance Proteobacteria Firmicutes/Bacteroides (F/B) ratio relative Bifidobacterium longum subsp . from controls without colonic neoplasia neoplasia, increased Candida glabrata controls, Conclusion Patients who underwent had significant dysbiosis. However, current could not detailed microbial structural functional associated CCE.

Language: Английский

Periodontitis Exacerbates Colorectal Cancer by Altering Gut Microbiota–Derived Metabolomics in Mice DOI Open Access
Xiaoxue Wang, Zhichao Li,

Haiquan Zhou

et al.

Journal of Periodontal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

ABSTRACT Aim The correlation between periodontitis and colorectal cancer (CRC) has drawn widespread attention. However, how affects CRC progression remains unclear. Methods C57BL/6 mice were used to establish experimental model. Histological alterations of periodontium colon observed by hematoxylin eosin staining. Micro‐computed tomography (micro‐CT) was applied evaluate alveolar bone loss (ABL). Tumor growth detected immunofluorescence. Gut bacteria analyzed using 16S rRNA sequencing. Gas chromatography–mass spectrometry (GC–MS) performed observe the gut microbial metabolites. detection associated pathways carried out quantitative real‐time PCR (qRT‐PCR). Results Experimental significantly induced increases in tumor number with CRC. Double immunofluorescence for Ki67 β‐catenin, as well Cyclin D1 indicated that observably promoted growth. sequencing untargeted metabolomics analysis displayed altered community metabolite profiles mice. Notably, we found dramatically increased level three oncometabolites (serotonin, adenosine, spermine) Conclusion Alterations metabolites might be relevant deteriorating

Language: Английский

Citations

0
Streptococcus anginosus: the potential role in the progression of gastric cancer DOI Creative Commons
Kun Xia, You Zhou, Wei Wang

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(4)

Published: April 19, 2025

Gastric cancer (GC) is among the most common and aggressive malignancies worldwide, characterized by a poor prognosis. Research on its pathogenesis progression continues to evolve. Streptococcus anginosus (S. anginosus, SA) Gram-positive coccus commonly found in oral cavity upper respiratory tract, serving as commensal bacterium oral, gastrointestinal, genitourinary tracts. It frequently associated with abscess formation various organs tissues, well other purulent infections. In recent years, S. has gained increasing attention for role GC progression, potentially leading chronic gastric inflammation precancerous lesions, ultimately promoting development of GC. Emerging evidence indicates strong association between malignant unfavorable prognosis This review summarizes underlying mechanisms proposes that plays pivotal initiation underscoring potential therapeutic significance.

Language: Английский

Citations

0
Oral Microbiota and the Risk of Gastrointestinal Cancers—A Narrative Literature Review DOI Creative Commons
Kinga Knop-Chodyła, Anna Kochanowska-Mazurek, Zuzanna Piasecka

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(9), P. 819 - 819

Published: Sept. 23, 2024

The human body is colonized by trillions of microorganisms in a symbiotic relationship. oral cavity represents one the most abundant microbial habitats our body. Advances sequencing techniques provide more detailed understanding microbiota and how imbalances between bacteria, phenomenon dysbiosis, can affect not only development dental caries or inflammation within but also systemic diseases cancers distant locations. This narrative review evaluates relationship its impact on gastrointestinal cancers. Using keywords “oral ‘AND’ cancers”, PubMed Web Science Scopus databases were searched for articles published 2014 2024. Based review, oral, esophageal, gastric, colorectal, hepatocellular, pancreatic was described. Potential oncogenic mechanisms exploited such as production pro-inflammatory cytokines, induction abnormal immune responses, disruption cell metabolic pathways assessed. Further research thorough tract may play key role their prevention, diagnosis, treatment future.

Language: Английский

Citations

1
Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis DOI Creative Commons
Tiing Leong Ang, Seok Hwee Koo, Daphne Ang

et al.

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

ABSTRACT Background Cholecystectomy (CCE) can affect the enterohepatic circulation of bile acids and result in gut microbiome changes. This systematic review aimed to clarify effect CCE on composition its clinical impact. Method A search was conducted PubMed, Web Science, Scopus, combining keywords such as “cholecystectomy” or “post‐cholecystectomy” with “gut microbiome,” “stool dysbiosis.” Data were extracted synthesized using narrative review. Study quality assessed Newcastle‐Ottawa scale. Results total 1373 articles screened 14 studies selected. Significant but inconsistent changes reported. Changes observed alpha beta diversity. At phylum level, an increase Bacteroides Ascomycota, decrease Firmicutes, Actinomycetes, Basidiomycota, both Fusobacteria genus Prevotella a Faecalibacterium In post‐CCE diarrhea, decreased diversity, F/B ratio, , Phocaeicola vulgatus copri noted. For syndrome, higher abundance Proteobacteria Firmicutes/Bacteroides (F/B) ratio relative Bifidobacterium longum subsp . from controls without colonic neoplasia neoplasia, increased Candida glabrata controls, Conclusion Patients who underwent had significant dysbiosis. However, current could not detailed microbial structural functional associated CCE.

Language: Английский

Citations

0