CONTINUUM Lifelong Learning in Neurology,
Год журнала:
2023,
Номер
29(4), С. 1188 - 1204
Опубликована: Авг. 1, 2023
This
article
provides
an
overview
of
the
growing
body
evidence
showing
bidirectional
relationships
between
sleep
and
various
neurologic
disorders.Mounting
demonstrates
that
disrupted
can
negatively
impact
disease
processes,
including
stroke,
multiple
sclerosis,
epilepsy,
neuromuscular
disorders
amyotrophic
lateral
headache
syndromes.
Abnormal
also
be
a
precursor
to
Alzheimer
neurodegenerative
states
such
as
Parkinson
dementia
with
Lewy
bodies.
Interventions
improve
treat
obstructive
apnea
may
play
vital
role
in
preventing
development
progression.Sleep
are
common
among
patients
disorders.
To
provide
comprehensive
care
conditions,
neurologists
must
ask
about
issues
warrant
further
diagnostic
testing,
treatment,
medicine
referral
when
indicated.
Rapid
eye
movement
sleep
behavior
disorder
(RBD)
is
increasingly
recognized
in
patients
with
tauopathies,
but
its
significance
and
underpinnings
remain
unclear.
To
address
this
gap,
we
investigated
the
prevalence
of
self-reported
RBD
progressive
supranuclear
palsy
(PSP)
explored
clinical
imaging
correlates
using
18F-florzolotau
PET
imaging.
We
consecutively
enrolled
meeting
2017
Movement
Disorder
Society
criteria
for
PSP
at
a
Chinese
tertiary
hospital
between
May
2019
March
2022.
Patients
underwent
comprehensive
assessments
to
investigate
tau
deposition
patterns.
The
presence
was
identified
Single-Question
Screen,
while
frequency
retrospectively
collected
from
medical
history.
examined
148
recruited
ongoing
Progressive
Supranuclear
Palsy
Neuroimage
Initiative
cohort.
Self-reported
18.2%
participants
(27/148).
PSP-Richardson
syndrome
PSP-parkinsonism
reported
highest
frequencies
(21.7%
18.5%,
respectively),
compared
PSP-progressive
gait
freezing
(9.7%).
While
age
sex
were
similar
without
RBD,
former
group
exhibited
greater
disease
severity,
as
indicated
by
higher
Rating
Scale
(PSPrs)
scores
(38.0
vs
27.0,
effect
size
=
0.256,
p
0.002).
Furthermore,
had
significantly
binding
locus
coeruleus
(LC)
(1.50
1.38,
0.231,
0.003),
which
remained
significant
after
false
discovery
rate
correction
(p
0.042).
found
be
correlated
pathology
LC
(n
8,
r
0.752,
Notably,
symptoms
mediated
relationship
PSPrs
total
(proportion-mediated
2.09%,
95%
CI
0.01%-10.00%,
0.044).
Approximately
one-fifth
more
severe
motor
nonmotor
symptoms.
elevated
association
underscore
critical
role
disrupting
sleep-regulating
neural
circuits.
Future
studies
larger
sample
sizes
should
incorporate
polysomnography
further
elucidate
relationship.
Biomedicines,
Год журнала:
2023,
Номер
11(5), С. 1465 - 1465
Опубликована: Май 17, 2023
Post-Traumatic
Stress
Disorder
(PTSD)
is
a
chronic
psychiatric
disorder
that
occurs
following
exposure
to
traumatic
events.
Recent
evidence
suggests
PTSD
may
be
risk
factor
for
the
development
of
subsequent
neurodegenerative
disorders,
including
Alzheimer's
dementia
and
Parkinson's
disease.
Identification
biomarkers
known
associated
with
neurodegeneration
in
patients
would
shed
light
on
pathophysiological
mechanisms
linking
these
disorders
also
help
preventive
strategies
PTSD.
With
this
background,
PubMed
Scopus
databases
were
searched
studies
designed
identify
could
an
increased
Out
total
342
citations
retrieved,
29
identified
inclusion
review.
The
results
suggest
such
as
cerebral
cortical
thinning,
disrupted
white
matter
integrity,
specific
genetic
polymorphisms,
immune-inflammatory
alterations,
vitamin
D
deficiency,
metabolic
syndrome,
objectively
documented
parasomnias
are
significantly
predict
disorders.
biological
underlying
changes,
interactions
between
them,
explored.
Though
requiring
replication,
findings
highlight
number
pathways
plausibly
link
potentially
valuable
avenues
prevention
early
intervention.
Post-traumatic
stress
disorder
(PTSD)
is
a
chronic
psychiatric
that
occurs
following
exposure
to
traumatic
events.
The
prevalence
of
PTSD
estimated
be
5-10%
worldwide,
and
it
associated
with
significant
distress
disability.
Recent
evidence
suggests
may
risk
factor
for
the
development
subsequent
neurodegenerative
disorders,
including
Alzheimer’s
dementia
Parkinson’s
disease.
Identification
biomarkers
known
neurodegeneration
in
patients
would
shed
light
on
pathophysiological
mechanisms
linking
these
also
help
preventive
approaches
aimed
at
reducing
disorders
PTSD.
In
current
review,
PubMed
Scopus
databases
were
searched
studies
identifying
genetic,
biochemical,
neuroimaging
or
behavioral
markers
Out
total
342
citations
retrieved,
29
relevant
identified
inclusion
review.
results
suggest
several
potentially
biological
markers,
cerebral
cortical
thinning,
disrupted
white
matter
integrity,
specific
genetic
polymorphisms,
immune-inflammatory
alterations,
vitamin
D
deficiency,
metabolic
syndrome
parasomnias,
an
increased
Though
many
need
replication,
they
highlight
number
pathways
plausibly
link
valuable
avenues
prevention
early
intervention
this
patient
population.
NeuroImmunoModulation,
Год журнала:
2023,
Номер
30(1), С. 237 - 249
Опубликована: Янв. 1, 2023
The
ongoing
global
health
crisis
due
to
the
novel
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
significantly
impacted
all
aspects
of
life.
While
majority
early
research
following
disease
caused
by
SARS-CoV-2
(COVID-19)
focused
on
physiological
effects
virus,
a
substantial
body
subsequent
studies
shown
that
psychological
burden
infection
is
also
considerable.
Patients,
even
without
mental
illness
history,
were
at
increased
susceptibility
developing
and
sleep
disturbances
during
or
after
COVID-19
infection.
Viral
neurotropism
inflammatory
storm
damaging
blood-brain
barrier
have
been
proposed
as
possible
mechanisms
for
manifestations,
along
with
stressful
factors
indirect
consequences
such
thrombosis
hypoxia.
virus
found
infect
peripheral
olfactory
neurons
exploit
axonal
migration
pathways,
exhibiting
metabolic
changes
in
astrocytes
are
detrimental
fueling
building
neurotransmitters.
Patients
present
dysregulated
overactive
immune
responses,
resulting
impaired
neuronal
function
viability,
adversely
affecting
emotion
regulation.
Additionally,
several
risk
associated
neuropsychiatric
sequelae
infection,
female
sex,
age,
preexisting
neuropathologies,
severity
initial
sociological
status.
This
review
aimed
provide
an
overview
symptoms
developed
analyze
underlying
distress
dysfunction.
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 486 - 486
Опубликована: Май 11, 2024
Background:
The
COVID-19
pandemic
increased
symptoms
of
stress
and
anxiety
induced
changes
in
sleep
quality,
dream
activity,
parasomnia
episodes.
It
has
been
shown
that
stressful
factors
and/or
bad
habits
can
affect
behaviors.
However,
investigations
on
how
affected
sleep,
dreams,
episode
frequency
parasomnias
are
rare.
current
study
focuses
the
impact
a
specific
characterized
by
speech
production
(sleep
talking,
ST).
Methods:
We
selected
27
participants
with
frequent
ST
episodes
(STs)
during
compared
them
STs
from
previous
conducted
pre-pandemic
period.
All
performed
home
monitoring
through
logs
recorded
their
nocturnal
for
one
week.
Results:
observed
higher
group.
Moreover,
were
related
to
emotional
intensity
independent
condition.
was
associated
lower
bizarreness
dreams
There
no
differences
variables
between
two
groups.
Conclusion:
Overall,
these
results
suggest
effect
STs.
Both
qualitative
characteristics
this
population.
Current Opinion in Pulmonary Medicine,
Год журнала:
2024,
Номер
30(6), С. 583 - 588
Опубликована: Авг. 8, 2024
Purpose
of
review
Dreaming
has
only
recently
become
a
topic
scientific
research.
This
updates
current
findings
on
dream
studies,
emphasizing
recent
research
the
neural
mechanisms
dreaming.
Additionally,
it
summarizes
new
evidence
functional
role
dreams,
including
insights
from
studies
dreams
and
nightmares
during
coronavirus
disease
2019
(COVID-19)
pandemic.
Recent
advances
basis
mental
activity
sleep
have
shifted
towards
dream-related
phenomena,
such
as
experiences
in
relation
to
parasomnias
hypnagogic
hallucinations.
Although
some
are
consistent
with
main
models
explaining
recall
(i.e.,
continuity
hypothesis;
activation
hypothesis),
results
contrast
parieto-occipital
region
experience.
Moreover,
–
related
COVID-19
pandemic
underlined
that
could
express
emotion
regulation
processes
well
provide
simulation
reality
prepare
for
future
dangerous
or
social
interactions.
Summary
Overall,
we
highlighted
intricate
interplay
between
brain
regions
dreaming
suggest
serve
multiple
functions,
reflecting
waking-life
simulating
adaptive
responses
threats.
Understanding
bases
functions
can
valuable
into
human
health,
nevertheless,
further
is
needed.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12079 - 12079
Опубликована: Ноя. 10, 2024
Alpha-synuclein
(α-syn)
is
a
140-amino-acid,
intrinsically
disordered,
soluble
protein
that
abundantly
present
in
the
brain.
It
plays
crucial
role
maintaining
cellular
structures
and
organelle
functions,
particularly
supporting
synaptic
plasticity
regulating
neurotransmitter
turnover.
However,
for
reasons
not
yet
fully
understood,
α-syn
can
lose
its
physiological
begin
to
aggregate.
This
altered
disrupts
dopaminergic
transmission
causes
both
presynaptic
postsynaptic
dysfunction,
ultimately
leading
cell
death.
A
group
of
neurodegenerative
diseases
known
as
α-synucleinopathies
characterized
by
intracellular
accumulation
deposits
specific
neuronal
glial
cells
within
certain
brain
regions.
In
addition
Parkinson's
disease
(PD),
these
conditions
include
dementia
with
Lewy
bodies
(DLBs),
multiple
system
atrophy
(MSA),
pure
autonomic
failure
(PAF),
REM
sleep
behavior
disorder
(RBD).
Given
disorders
are
associated
α-syn-related
neuroinflammation-and
considering
SARS-CoV-2
infection
has
been
shown
affect
nervous
system,
COVID-19
patients
experiencing
neurological
symptoms-it
proposed
may
contribute
neurodegeneration
PD
other
promoting
misfolding
aggregation.
this
review,
we
focus
on
whether
could
act
an
environmental
trigger
facilitates
onset
or
progression
α-synucleinopathies.
Specifically,
new
evidence
potential
modulating
function
discuss
causal
relationship
between
development
parkinsonism-like
symptoms.
