Light therapy in insomnia disorder: A systematic review and meta‐analysis

Journal of Sleep Research, Год журнала: 2023, Номер 32(6)

Опубликована: Апрель 1, 2023

Summary In the management of insomnia, physicians and patients are seeking alternative therapeutics to sleeping pills, in addition sleep hygiene cognitive behavioural therapy. Bright light therapy (LT) has proven its efficacy circadian mood disorders. We conducted a systematic literature review meta‐analysis according Cochrane PRISMA guidelines using databases Medline, Cochrane, Web Science, with special focus on insomnia. Twenty‐two studies total 685 participants were included, five which high level proof. Meta‐analysis was performed 13 them: for insomnia compared control conditions significantly improved wake after onset (WASO: SMD = −0.61 [−1.11, −0.11]; p 0.017; weighted difference 11.2 min ±11.5 based actigraphy, −1.09 [−1.43, −0.74] ( < 0.001) −36.4 ±15.05) diary, but no other measures such as latency, time (TST), or efficiency. Qualitative analysis showed some improvement mainly subjective measures. Morning exposure advanced sleep–wake rhythms evening led delay. No worsening observed objective nor measures, except TST one study exposure. A dose–response may exist studies’ heterogeneity publication bias limit interpretation. To conclude, shows effectiveness maintenance disorders, further research is needed refine parameters be chosen type hope developing personalised therapeutics.

Язык: Английский

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The stress of losing sleep: Sex-specific neurobiological outcomes

Neurobiology of Stress, Год журнала: 2023, Номер 24, С. 100543 - 100543

Опубликована: Май 1, 2023

Sleep is a vital and evolutionarily conserved process, critical to daily functioning homeostatic balance. Losing sleep inherently stressful leads numerous detrimental physiological outcomes. Despite disturbances affecting everyone, women female rodents are often excluded or underrepresented in clinical pre-clinical studies. Advancing our understanding of the role biological sex responses loss stands greatly improve ability understand treat health consequences insufficient sleep. As such, this review discusses differences response deprivation, with focus on sympathetic nervous system stress activation hypothalamic-pituitary-adrenal (HPA) axis. We several stress-related loss, including inflammation, learning memory deficits, mood related changes. Focusing women's health, we discuss effects deprivation during peripartum period. In closing, present neurobiological mechanisms, contribution hormones, orexins, circadian timing systems, astrocytic neuromodulation, that may underlie potential responses.

Язык: Английский

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Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy

Neuropeptides, Год журнала: 2023, Номер 99, С. 102335 - 102335

Опубликована: Март 24, 2023

Язык: Английский

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Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities

Neuropharmacology, Год журнала: 2023, Номер 245, С. 109815 - 109815

Опубликована: Дек. 17, 2023

Orexin is a neurotransmitter produced by small group of hypothalamic neurons. Besides its well-known role in the regulation sleep-wake cycle, orexin system was shown to be relevant several physiological functions including cognition, mood and emotion modulation, energy homeostasis. Indeed, implication neurotransmission neurological psychiatric diseases has been hypothesized via direct effect exerted projections neurons brain areas, an indirect through orexin-mediated modulation sleep wake. Along with growing evidence concerning use dual receptor antagonists (DORAs) treatment insomnia, studies assessing their efficacy insomnia comorbid have set order investigate potential impact DORAs on both sleep-related symptoms disease-specific manifestations. This narrative review aimed at summarizing current conditions also discussing possible modulating for improving burden pathological mechanisms these disorders. Target searches were performed PubMed/MEDLINE Scopus databases ongoing registered Clinicaltrials.gov reviewed. Despite some contradictory findings, preclinical seemingly support beneficial antagonism management most common comorbidities. However, clinical research still limited further are needed corroborating promising preliminary results.

Язык: Английский

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Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort

SLEEP, Год журнала: 2023, Номер 47(2)

Опубликована: Окт. 27, 2023

Abstract Study Objectives To assess for associations between sleeping more than or less recommended by the National Sleep Foundation (NSF), and self-reported insomnia, with brain structure. Methods Data from UK Biobank cohort were analyzed (N 9K 32K, dependent on availability, aged 44 to 82 years). measures included adherence NSF guidelines sleep duration (sleeping 7 9 hours per night), difficulty falling staying asleep (insomnia). Brain structural global regional cortical subcortical morphometry (thickness, surface area, volume), tract-related white matter microstructure, age gap (difference chronological estimated scan), total volume of lesions. Results Longer-than-recommended was associated lower overall grey volumes, thickness measures, higher gap, lesions, mean diffusivity globally in thalamic association fibers, hippocampus. Shorter-than-recommended related cerebellar areas, fractional anisotropy projection fibers. Self-reported insomnia gray volumes amygdala, hippocampus, putamen. Conclusions Sleeping longer is a wide range differences structure, potentially indicative poorer health. distinctly areas. Future studies should potential mechanisms these investigate long as putative marker

Язык: Английский

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Unraveling the complex interplay between insomnia, anxiety, and brain networks

SLEEP, Год журнала: 2024, Номер 47(3)

Опубликована: Янв. 9, 2024

Язык: Английский

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Sleep Health

Clinical and Translational Neuroscience, Год журнала: 2024, Номер 8(1), С. 8 - 8

Опубликована: Янв. 24, 2024

Together with (physical and mental) exercise, diet, social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part this review, we present current knowledge on how promotes body, brain, mental, occupational, as well creativity, productivity, well-being. second part, discuss good screening for sleep–wake disorders may improve reduce burden cardiovascular, metabolic cancer. We also review literature measurements Bernese Sleep Health Questionnaire, new simple tool to assess screen circadian in clinical practice.

Язык: Английский

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Sleep is Essential for Mental Health: Potential Role of Slow Oscillations

Current Sleep Medicine Reports, Год журнала: 2024, Номер 10(1), С. 13 - 22

Опубликована: Янв. 26, 2024

Язык: Английский

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Early experience with the new DORA daridorexant in patients with insomnia disorder and comorbid mental disturbances: Results of a naturalistic study with 3 months follow‐up

Journal of Sleep Research, Год журнала: 2024, Номер unknown

Опубликована: Март 24, 2024

Summary Insomnia disorder may affect mental health, increasing suicidal risk. Targeting insomnia is crucial in the clinical practice. Sixty‐six consecutive patients with according DSM‐5‐TR criteria were treated dual orexin receptor antagonist, daridorexant 50 mg. Baseline (T0), 1 month (T1) and 3 (T2) evaluations performed. severity (Insomnia Severity Index), mood, anxiety symptoms risk (Beck Depression Inventory‐II, Young Mania Rating Scale, Self‐Reported Anxiety Suicidal Ideation Scale), dysfunctional insomnia‐cognitive factors pre‐sleep arousal (Dysfunctional Beliefs About Sleep, Pre‐Sleep Arousal Scale) evaluated. The final sample included 66 ( n = 36, 54% females, mean age 60 ± 13.6 years). Most of them, 64%, suffered from comorbid unipolar/bipolar depression, disorders substance use disorders. Repeated ANOVA analyses showed that Index, Dysfunctional Sleep Scale total score decreased across time F 68.818, p < 0.001; 47.561, 28.142, 0.001, respectively). Similarly, Beck significantly over 0.001). Predictors remission Index 8) at T1 improvement 60.205, 0.001), 4.432, 0.041). T2 was best predicted by 3.993, 0.023). Multiple‐regression models Inventory‐II T2, manic somatic T2. With caution a naturalistic design, early experience targeting it be possible to improve not only but also symptoms.

Язык: Английский

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Network analysis of anxiety and depressive symptoms during the COVID-19 pandemic in older adults in the United Kingdom

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 2, 2024

Abstract The health crisis caused by COVID-19 in the United Kingdom and confinement measures that were subsequently implemented had unprecedented effects on mental of older adults, leading to emergence exacerbation different comorbid symptoms including depression anxiety. This study examined compared anxiety symptom networks two specific quarantine periods (June–July November–December) adult population Kingdom. We used database English Longitudinal Study Aging Substudy, consisting 5797 participants first stage (54% women) 6512 second (56% women), all over 50 years age. with highest centrality both times were: “Nervousness (A1)” “Inability relax (A4)” expected influence predictability, “depressed mood (D1”; bridging influence). latter measure along "Irritability (A6)" overlapped clusters networks. In addition, a cross-lagged panel network model was which more significant direction "Nervousness (A1)" depressive "Anhedonia (D6)", "Hopelessness (D7)", "Sleep problems (D3)" observed; has predictive capability network. results report higher degree transdiagnostic overlap cross-sectional (invariants) anxious symptomatology.

Язык: Английский

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