Prognostic value of inflammation-related model in hepatitis B acute-on-chronic liver failure DOI Creative Commons
Huimian Xu,

xue Li,

Yue Zhuo

и другие.

Advances in Clinical and Experimental Medicine, Год журнала: 2024, Номер 34(11), С. 0 - 0

Опубликована: Ноя. 18, 2024

Acute-on-chronic liver failure (ACLF) is characterized by rapid onset, development and a high short-term mortality rate. Systemic inflammation exerts an effect on the disease progression of ACLF.

Язык: Английский

Hypermethylation of the glutathione peroxidase 4 promoter predicts poor prognosis in patients with hepatitis B virus-associated acute-on-chronic liver failure DOI Creative Commons
Xing Su,

Li‐Yan Han,

Jing Wang

и другие.

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Июль 25, 2024

Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a syn-drome with high short-term mortality rate, and its prognosis critical in clinical management. This study aimed to investigate the significance of glutathione peroxidase 4 (GPX4) occurrence development HBV-ACLF prognostic value for 90-day mortality.

Язык: Английский

Процитировано

0
New perspectives in the definition and classification of acute-on-chronic liver failure DOI Creative Commons
Manman Xu, Yu Chen

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

0
Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure DOI Creative Commons
Yu Xia,

Ruoqi Zhou,

Wenting Tan

и другие.

eGastroenterology, Год журнала: 2024, Номер 2(3), С. e100101 - e100101

Опубликована: Окт. 1, 2024

The model for end-stage liver disease (MELD) score is widely used the prognostication in but has limited performance acute-on-chronic failure (ACLF). In this study, we identified additional predictive parameters and reformed MELD to predict ACLF more accurately. A meta-analysis was performed on relevant studies identify factors of 28-day/90-day outcomes ACLF, which were validated two large prospective cohorts. prognostic developed by incorporating into score. evaluated with a focus discrimination calibration. incorporated 32 cohort total 13 939 patients, risk identified, 3 (age, neutrophil count hepatic encephalopathy (HE) grade) besides 751 patients derived from new (Chinese Acute-on-Chronic Liver Failure Consortium (CATCH-LIFE)-MELD score) as follows: 0.028×age+0.3×HE grade+0.039×neutrophil count+0.079×MELD CATCH-LIFE-MELD achieved concordance index 0.791/0.788 outcomes, superior other traditional scores. Other indices, including net reclassification improvement, integrated improvement probability density function, calibration Nagelkerke's R2 Brier scores confirmed its superiority. Moreover, accuracy remained stable. It highest or without hepatitis B virus infection, cirrhosis, under Chinese Group Study Severe Hepatitis (COSSH) criteria European Association (EASL) criteria. All results substantiated an evaluation using external cohort. score, modified exhibited improved predicting short-term prognosis than

Язык: Английский

Процитировано

0
Prognostic value of inflammation-related model in hepatitis B acute-on-chronic liver failure DOI Creative Commons
Huimian Xu,

xue Li,

Yue Zhuo

и другие.

Advances in Clinical and Experimental Medicine, Год журнала: 2024, Номер 34(11), С. 0 - 0

Опубликована: Ноя. 18, 2024

Acute-on-chronic liver failure (ACLF) is characterized by rapid onset, development and a high short-term mortality rate. Systemic inflammation exerts an effect on the disease progression of ACLF.

Язык: Английский

Процитировано

0